Potential function for the Huntingtin protein as a scaffold for selective autophagy. - Wikidata - wikimedia - TriplyDB

Potential function for the Huntingtin protein as a scaffold for selective autophagy.

Potential function for the Huntingtin protein as a scaffold for selective autophagy.

http://www.wikidata.org/entity/Q30301372

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The Function of Autophagy in Neurodegenerative Diseases The different roles of selective autophagic protein degradation in mammalian cells Hypoxia signaling pathways: modulators of oxygen-related organelles Autophagy in polyglutamine disease: Imposing order on disorder or contributing to the chaos?Therapeutic targeting of autophagy in neurodegenerative and infectious diseases Drosophila as an In Vivo Model for Human Neurodegenerative Disease Neuronal Mitophagy in Neurodegenerative Diseases Generation and Characterization of Knock-in Mouse Models Expressing Versions of Huntingtin with Either an N17 or a Combined PolyQ and Proline-Rich Region Deletion.Is Huntingtin Dispensable in the Adult Brain?Serine 421 regulates mutant huntingtin toxicity and clearance in mice.N-terminal Huntingtin Knock-In Mice: Implications of Removing the N-terminal Region of Huntingtin for Therapy.AUTEN-67 (Autophagy Enhancer-67) Hampers the Progression of Neurodegenerative Symptoms in a Drosophila model of Huntington's Disease.Contributions to magnetic susceptibility of brain tissue.Huntingtin proteolysis releases non-polyQ fragments that cause toxicity through dynamin 1 dysregulation.Blocking the association of HDAC4 with MAP1S accelerates autophagy clearance of mutant Huntingtin.The small molecule AUTEN-99 (autophagy enhancer-99) prevents the progression of neurodegenerative symptoms.The Autophagy-Lysosomal Pathway in Neurodegeneration: A TFEB Perspective VCP recruitment to mitochondria causes mitophagy impairment and neurodegeneration in models of Huntington's disease.iLIR database: A web resource for LIR motif-containing proteins in eukaryotes.Oxidative Stress and Huntington's Disease: The Good, The Bad, and The Ugly.Autophagy and Microglia: Novel Partners in Neurodegeneration and Aging.Autophagic activity in neuronal cell death Primary cilia and autophagic dysfunction in Huntington's disease.Studying polyglutamine diseases in Drosophila.Iron and Neurodegeneration: Is Ferritinophagy the Link?Huntington's Disease: Pathogenic Mechanisms and Therapeutic Targets.Potential Transfer of Polyglutamine and CAG-Repeat RNA in Extracellular Vesicles in Huntington's Disease: Background and Evaluation in Cell Culture.Modulation of Molecular Chaperones in Huntington's Disease and Other Polyglutamine Disorders.Mechanistic insights into selective autophagy pathways: lessons from yeast.Huntington's Disease: Mechanisms of Pathogenesis and Therapeutic Strategies.Huntingtin polyQ Mutation Impairs the 17β-Estradiol/Neuroglobin Pathway Devoted to Neuron Survival.Autophagy and Human Neurodegenerative Diseases-A Fly's Perspective.Targeting TEAD/YAP-transcription-dependent necrosis, TRIAD, ameliorates Huntington's disease pathology.Receptor-Bound Targets of Selective Autophagy Use a Scaffold Protein to Activate the Atg1 Kinase.CCT complex restricts neuropathogenic protein aggregation via autophagy.CRISPR/Cas9 Editing of the Mutant Huntingtin Allele In Vitro and In Vivo.Allele-Specific Reduction of the Mutant Huntingtin Allele Using Transcription Activator-Like Effectors in Human Huntington's Disease Fibroblasts.Huntingtin facilitates selective autophagy.Suppression of MAPK11 or HIPK3 reduces mutant Huntingtin levels in Huntington's disease models.Inhibition of PIP4Kγ ameliorates the pathological effects of mutant huntingtin protein.

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Potential function for the Huntingtin protein as a scaffold for selective autophagy.

http://www.wikidata.org/entity/Q30301372

description

2014 nî lūn-bûn

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2014 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած

@hyw

2014 թվականի նոյեմբերին հրատարակված գիտական հոդված

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2014年の論文

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2014年論文

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2014年論文

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2014年論文

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2014年論文

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2014年論文

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2014年论文

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name

Potential function for the Huntingtin protein as a scaffold for selective autophagy.

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Potential function for the Huntingtin protein as a scaffold for selective autophagy.

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type

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Potential function for the Huntingtin protein as a scaffold for selective autophagy.

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Potential function for the Huntingtin protein as a scaffold for selective autophagy.

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prefLabel

Potential function for the Huntingtin protein as a scaffold for selective autophagy.

@ast

Potential function for the Huntingtin protein as a scaffold for selective autophagy.

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PNAS.1420103111

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Proceedings of the National Academy of Sciences of the United States of America

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Potential function for the Huntingtin protein as a scaffold for selective autophagy.

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P2093

Alice L Lau

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David E Housman

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Frédéric Saudou

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George Csikos

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J Lawrence Marsh

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Joan S Steffan

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Joseph Ochaba

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Julia Margulis

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Leslie M Thompson

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Lisa Salazar

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P2860

Ciliogenesis is regulated by a huntingtin-HAP1-PCM1 pathway and is altered in Huntington disease

Huntingtin is required for mitotic spindle orientation and mammalian neurogenesis

Phosphorylation of the autophagy receptor optineurin restricts Salmonella growth

A core complex of BBS proteins cooperates with the GTPase Rab8 to promote ciliary membrane biogenesis

Microtubule-associated protein 1 light chain 3 (LC3) interacts with Bnip3 protein to selectively remove endoplasmic reticulum and mitochondria via autophagy

Eukaryotic stress granules are cleared by autophagy and Cdc48/VCP function

The many faces of autophagy dysfunction in Huntington's disease: from mechanism to therapy

Huntingtin's function in axonal transport is conserved in Drosophila melanogaster

Deficiency of huntingtin has pleiotropic effects in the social amoeba Dictyostelium discoideum

Structural basis of target recognition by Atg8/LC3 during selective autophagy

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47

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111

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Daniel J. Klionsky

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268984039

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