Extracellular signal-regulated kinase functions in the urokinase receptor-dependent pathway by which neutralization of low density lipoprotein receptor-related protein promotes fibrosarcoma cell migration and matrigel invasion.
about
Stabilization of urokinase and urokinase receptor mRNAs by HuR is linked to its cytoplasmic accumulation induced by activated mitogen-activated protein kinase-activated protein kinase 2The Matricellular Receptor LRP1 Forms an Interface for Signaling and Endocytosis in Modulation of the Extracellular Tumor EnvironmentPlasminogen activator inhibitor 1 functions as a urokinase response modifier at the level of cell signaling and thereby promotes MCF-7 cell growth.Regulation of Rac1 activation by the low density lipoprotein receptor-related proteinLDL receptor-related protein-1: a regulator of inflammation in atherosclerosis, cancer, and injury to the nervous systemProtein kinase C-alpha-mediated regulation of low-density lipoprotein receptor related protein and urokinase increases astrocytoma invasionLRP1 regulates remodeling of the extracellular matrix by fibroblasts.Low density lipoprotein receptor-related protein (LRP1) regulates Rac1 and RhoA reciprocally to control Schwann cell adhesion and migration.LRP-1 promotes cancer cell invasion by supporting ERK and inhibiting JNK signaling pathwaysThe fibrinolytic receptor for urokinase activates the G protein-coupled chemotactic receptor FPRL1/LXA4R.Cell cholesterol modulates metalloproteinase-dependent shedding of low-density lipoprotein receptor-related protein-1 (LRP-1) and clearance function.RNAi-mediated downregulation of urokinase plasminogen activator and its receptor in human meningioma cells inhibits tumor invasion and growth.SPRY1 promotes the degradation of uPAR and inhibits uPAR-mediated cell adhesion and proliferationLRP-1: functions, signaling and implications in kidney and other diseases.Differential signaling by adaptor molecules LRP1 and ShcA regulates adipogenesis by the insulin-like growth factor-1 receptorEffects of ulinastatin and docetaxel on breast cancer invasion and expression of uPA, uPAR and ERKActivation of mitogen-activated protein kinase is required for migration and invasion of placental site trophoblastic tumor.The triptolide derivative MRx102 inhibits Wnt pathway activation and has potent anti-tumor effects in lung cancer.Paxillin phosphorylation and complexing with Erk and FAK are regulated by PLD activity in MDA-MB-231 cellsLRP-1--CD44, a new cell surface complex regulating tumor cell adhesion.Pertussis Toxin Is a Robust and Selective Inhibitor of High Grade Glioma Cell Migration and Invasion.MEK inhibition suppresses cell invasion and migration in ovarian cancers with activation of ERK1/2.HLA class I-mediated stress fiber formation requires ERK1/2 activation in the absence of an increase in intracellular Ca2+ in human aortic endothelial cellsDynamic phosphorylation of tyrosine 665 in pseudopodium-enriched atypical kinase 1 (PEAK1) is essential for the regulation of cell migration and focal adhesion turnoverLRP-1 silencing prevents malignant cell invasion despite increased pericellular proteolytic activitiesRegulation of tumor necrosis factor receptor-1 and the IKK-NF-kappaB pathway by LDL receptor-related protein explains the antiinflammatory activity of this receptorAng II-stimulated migration of vascular smooth muscle cells is dependent on LR11 in mice.uPA impairs cerebrovasodilation after hypoxia/ischemia through LRP and ERK MAPKRole of urokinase receptor in tumor progression and development.The many spaces of uPAR: delivery of theranostic agents and nanobins to multiple tumor compartments through a single targetLRP-1: a new modulator of cytoskeleton dynamics and adhesive complex turnover in cancer cellsProteolytic and non-proteolytic roles of membrane type-1 matrix metalloproteinase in malignancyDevelopment of novel therapeutics targeting the urokinase plasminogen activator receptor (uPAR) and their translation toward the clinic.Transforming growth factor-Beta and urokinase-type plasminogen activator: dangerous partners in tumorigenesis-implications in skin cancer.Downregulation of urokinase plasminogen activator receptor expression inhibits Erk signalling with concomitant suppression of invasiveness due to loss of uPAR-beta1 integrin complex in colon cancer cells.Suppression of uPA and uPAR blocks radiation-induced MCP-1 mediated recruitment of endothelial cells in meningioma.Timp-2 binding with cellular MT1-MMP stimulates invasion-promoting MEK/ERK signaling in cancer cells.Low-density lipoprotein receptor-related protein 1 promotes cancer cell migration and invasion by inducing the expression of matrix metalloproteinases 2 and 9.An uncleavable uPAR mutant allows dissection of signaling pathways in uPA-dependent cell migration.The mosaic receptor sorLA/LR11 binds components of the plasminogen-activating system and platelet-derived growth factor-BB similarly to LRP1 (low-density lipoprotein receptor-related protein), but mediates slow internalization of bound ligand.
P2860
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P2860
Extracellular signal-regulated kinase functions in the urokinase receptor-dependent pathway by which neutralization of low density lipoprotein receptor-related protein promotes fibrosarcoma cell migration and matrigel invasion.
description
2000 nî lūn-bûn
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2000 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2000 թվականի հունվարին հրատարակված գիտական հոդված
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2000年の論文
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2000年論文
@yue
2000年論文
@zh-hant
2000年論文
@zh-hk
2000年論文
@zh-mo
2000年論文
@zh-tw
2000年论文
@wuu
name
Extracellular signal-regulated ...... gration and matrigel invasion.
@ast
Extracellular signal-regulated ...... gration and matrigel invasion.
@en
type
label
Extracellular signal-regulated ...... gration and matrigel invasion.
@ast
Extracellular signal-regulated ...... gration and matrigel invasion.
@en
prefLabel
Extracellular signal-regulated ...... gration and matrigel invasion.
@ast
Extracellular signal-regulated ...... gration and matrigel invasion.
@en
P2093
P1476
Extracellular signal-regulated ...... gration and matrigel invasion.
@en
P2093
P304
P407
P478
113 ( Pt 1)
P577
2000-01-01T00:00:00Z