Downregulation of urokinase plasminogen activator receptor expression inhibits Erk signalling with concomitant suppression of invasiveness due to loss of uPAR-beta1 integrin complex in colon cancer cells.
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ERp29 induces breast cancer cell growth arrest and survival through modulation of activation of p38 and upregulation of ER stress protein p58IPKRNA interference-directed knockdown of urokinase plasminogen activator and urokinase plasminogen activator receptor inhibits prostate cancer cell invasion, survival, and tumorigenicity in vivoActivation of focal adhesion kinase enhances the adhesion and invasion of pancreatic cancer cells via extracellular signal-regulated kinase-1/2 signaling pathway activation.Interleukin-1alpha enhances the aggressive behavior of pancreatic cancer cells by regulating the alpha6beta1-integrin and urokinase plasminogen activator receptor expressionuPAR and cathepsin B-mediated compartmentalization of JNK regulates the migration of glioma-initiating cellsTyrosine-kinase inhibition results in EGFR clustering at focal adhesions and consequent exocytosis in uPAR down-regulated cells of head and neck cancers.Functional live-cell imaging demonstrates that beta1-integrin promotes type IV collagen degradation by breast and prostate cancer cellsHormonal regulation and distinct functions of semaphorin-3B and semaphorin-3F in ovarian cancer.Targeting of the β6 gene to suppress degradation of ECM via inactivation of the MAPK pathway in breast adenocarcinoma cells.Toll-like receptors at the maternal-fetal interface in normal pregnancy and pregnancy disorders.Coordinate regulation of fibronectin matrix assembly by the plasminogen activator system and vitronectin in human osteosarcoma cells.Alpha2beta1 integrin affects metastatic potential of ovarian carcinoma spheroids by supporting disaggregation and proteolysis.RNA interference-mediated targeting of urokinase plasminogen activator receptor and matrix metalloproteinase-9 gene expression in the IOMM-lee malignant meningioma cell line inhibits tumor growth, tumor cell invasion and angiogenesis.Coalition of Oct4A and β1 integrins in facilitating metastasis in ovarian cancer.Characterization of ovarian cancer ascites on cell invasion, proliferation, spheroid formation, and gene expression in an in vitro model of epithelial ovarian cancer.Design, synthesis, biochemical studies, cellular characterization, and structure-based computational studies of small molecules targeting the urokinase receptor.Regulation of alpha5beta1 integrin conformation and function by urokinase receptor binding.Oncodomains: A protein domain-centric framework for analyzing rare variants in tumor samples.Inhibition of urokinase plasminogen activator with a novel enzyme inhibitor, WXC-340, ameliorates endotoxin and surgery-accelerated growth of murine metastases.Ascites induces modulation of alpha6beta1 integrin and urokinase plasminogen activator receptor expression and associated functions in ovarian carcinoma.Is there a genetic signature for liver metastasis in colorectal cancer?Decreased MALL expression negatively impacts colorectal cancer patient survivalECRG2 regulates cell migration/invasion through urokinase-type plasmin activator receptor (uPAR)/beta1 integrin pathway.Signaling through urokinase and urokinase receptor in lung cancer cells requires interactions with beta1 integrins.Aeroallergen Der p 2 promotes motility of human non-small cell lung cancer cells via toll-like receptor-mediated up-regulation of urokinase-type plasminogen activator and integrin/focal adhesion kinase signaling.Unique patterns of metastases in common and rare types of malignancy.A novel peptide blocking cancer cell invasion by structure-based drug design.TUSC3 promotes colorectal cancer progression and epithelial-mesenchymal transition (EMT) through WNT/β-catenin and MAPK signalling.High Erk activity suppresses expression of the cell cycle inhibitor p27Kip1 in colorectal cancer cellsDownregulation of E-cadherin is an essential event in activating beta-catenin/Tcf-dependent transcription and expression of its target genes in Pdcd4 knockdown cells.Coptisine from Rhizoma Coptidis Suppresses HCT-116 Cells-related Tumor Growth in vitro and in vivoThe Significance of TROP2 Expression in Predicting BRAF Mutations in Papillary Thyroid Carcinoma.
P2860
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P2860
Downregulation of urokinase plasminogen activator receptor expression inhibits Erk signalling with concomitant suppression of invasiveness due to loss of uPAR-beta1 integrin complex in colon cancer cells.
description
2003 nî lūn-bûn
@nan
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
2003年论文
@zh
2003年论文
@zh-cn
name
Downregulation of urokinase pl ...... complex in colon cancer cells.
@en
type
label
Downregulation of urokinase pl ...... complex in colon cancer cells.
@en
prefLabel
Downregulation of urokinase pl ...... complex in colon cancer cells.
@en
P2093
P2860
P356
P1476
Downregulation of urokinase pl ...... complex in colon cancer cells.
@en
P2093
P2860
P2888
P304
P356
10.1038/SJ.BJC.6601098
P407
P577
2003-07-01T00:00:00Z
P5875
P6179
1039718552