Cooperativity between the Ras-ERK and Rho-Rho kinase pathways in urokinase-type plasminogen activator-stimulated cell migration.
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Stabilization of urokinase and urokinase receptor mRNAs by HuR is linked to its cytoplasmic accumulation induced by activated mitogen-activated protein kinase-activated protein kinase 2Endosomes generate localized Rho-ROCK-MLC2-based contractile signals via Endo180 to promote adhesion disassemblyThe MEK1 scaffolding protein MP1 regulates cell spreading by integrating PAK1 and Rho signals.Up-regulation of RhoGDI2 in human breast cancer and its prognostic implicationsMatrix-bound PAI-1 supports cell blebbing via RhoA/ROCK1 signalingPlasminogen Activator System and Breast Cancer: Potential Role in Therapy Decision Making and Precision MedicineOsteoblast-derived oxysterol is a migration-inducing factor for human breast cancer cellsLoss of Rho GDIα and resistance to tamoxifen via effects on estrogen receptor αSoluble urokinase-type plasminogen activator receptor inhibits cancer cell growth and invasion by direct urokinase-independent effects on cell signaling.Extracellular signal-regulated kinase promotes Rho-dependent focal adhesion formation by suppressing p190A RhoGAP.Insulin-like growth factor I controls adhesion strength mediated by alpha5beta1 integrins in motile carcinoma cells.Suppression of uPA and uPAR attenuates angiogenin mediated angiogenesis in endothelial and glioblastoma cell linesEpigenetic upregulation of urokinase plasminogen activator promotes the tropism of mesenchymal stem cells for tumor cells.Mechanism of Akt1 inhibition of breast cancer cell invasion reveals a protumorigenic role for TSC2.RNAi-mediated downregulation of urokinase plasminogen activator and its receptor in human meningioma cells inhibits tumor invasion and growth.The heme oxygenase-1 protein is overexpressed in human renal cancer cells following activation of the Ras-Raf-ERK pathway and mediates anti-apoptotic signal.GPI-anchored uPAR requires Endo180 for rapid directional sensing during chemotaxis.Scaffold mediated regulation of MAPK signaling and cytoskeletal dynamics: a perspective.A peptide inhibitor of the urokinase/urokinase receptor system inhibits alteration of the blood-retinal barrier in diabetes.uPA/uPAR downregulation inhibits radiation-induced migration, invasion and angiogenesis in IOMM-Lee meningioma cells and decreases tumor growth in vivo.Domain 2 of uPAR regulates single-chain urokinase-mediated angiogenesis through β1-integrin and VEGFR2Discoidin domain receptor 1 promotes Th17 cell migration by activating the RhoA/ROCK/MAPK/ERK signaling pathway.Disruption of tissue-type plasminogen activator gene in mice reduces renal interstitial fibrosis in obstructive nephropathy.Suppression of uPA and uPAR blocks radiation-induced MCP-1 mediated recruitment of endothelial cells in meningioma.Erythropoietin promotes MCF-7 breast cancer cell migration by an ERK/mitogen-activated protein kinase-dependent pathway and is primarily responsible for the increase in migration observed in hypoxia.Trihydrophobin 1 Interacts with PAK1 and Regulates ERK/MAPK Activation and Cell Migration.uPA/PAI-1 expression and uPA promoter methylation in meningiomas.Plasminogen activator inhibitor-1 and -3 increase cell adhesion and motility of MDA-MB-435 breast cancer cells.SU1498, an inhibitor of vascular endothelial growth factor receptor 2, causes accumulation of phosphorylated ERK kinases and inhibits their activity in vivo and in vitro.Inhibition of geranylgeranylation mediates the effects of 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase inhibitors on microglia.Multiple signaling pathways are involved in endothelin-1-induced brain endothelial cell migration.Targeting the cross-talk between Urokinase receptor and Formyl peptide receptor type 1 to prevent invasion and trans-endothelial migration of melanoma cells.Urokinase plasminogen activator receptor induced non-small cell lung cancer invasion and metastasis requires NHE1 transporter expression and transport activity.
P2860
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P2860
Cooperativity between the Ras-ERK and Rho-Rho kinase pathways in urokinase-type plasminogen activator-stimulated cell migration.
description
2002 nî lūn-bûn
@nan
2002 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
name
Cooperativity between the Ras- ...... tor-stimulated cell migration.
@ast
Cooperativity between the Ras- ...... tor-stimulated cell migration.
@en
type
label
Cooperativity between the Ras- ...... tor-stimulated cell migration.
@ast
Cooperativity between the Ras- ...... tor-stimulated cell migration.
@en
prefLabel
Cooperativity between the Ras- ...... tor-stimulated cell migration.
@ast
Cooperativity between the Ras- ...... tor-stimulated cell migration.
@en
P2093
P356
P1476
Cooperativity between the Ras- ...... tor-stimulated cell migration.
@en
P2093
Andrew P Somlyo
Avril V Somlyo
Keena S Thomas
Steven L Gonias
P304
12479-12485
P356
10.1074/JBC.M111147200
P407
P577
2002-01-22T00:00:00Z