Mechanism of Akt1 inhibition of breast cancer cell invasion reveals a protumorigenic role for TSC2. - Wikidata - wikimedia - TriplyDB

Mechanism of Akt1 inhibition of breast cancer cell invasion reveals a protumorigenic role for TSC2.

Mechanism of Akt1 inhibition of breast cancer cell invasion reveals a protumorigenic role for TSC2.

http://www.wikidata.org/entity/Q34427178

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Vimentin is a novel AKT1 target mediating motility and invasion A comprehensive panel of three-dimensional models for studies of prostate cancer growth, invasion and drug responses HoxA5 stabilizes adherens junctions via increased Akt1 Computational modeling and analysis of insulin induced eukaryotic translation initiation Active PI3K pathway causes an invasive phenotype which can be reversed or promoted by blocking the pathway at divergent nodes Regulation of PI3K effector signalling in cancer by the phosphoinositide phosphatases Akt1 governs breast cancer progression in vivo.Identification of FGFR4-activating mutations in human rhabdomyosarcomas that promote metastasis in xenotransplanted models.The actin-bundling protein palladin is an Akt1-specific substrate that regulates breast cancer cell migration The PI3K-Akt-mTOR pathway in initiation and progression of thyroid tumors.Signaling specificity in the Akt pathway in biology and disease.A network-based biomarker approach for molecular investigation and diagnosis of lung cancer.Subcellular localization of activated AKT in estrogen receptor- and progesterone receptor-expressing breast cancers: potential clinical implications Distinct roles of the three Akt isoforms in lactogenic differentiation and involution.Boolean ErbB network reconstructions and perturbation simulations reveal individual drug response in different breast cancer cell lines.Inhibition of phosphatidylinositol 3-kinase/Akt signaling suppresses tumor cell proliferation and neuroendocrine marker expression in GI carcinoid tumors Breast cancer cells in three-dimensional culture display an enhanced radioresponse after coordinate targeting of integrin alpha5beta1 and fibronectin.Role of lifeguard β-isoform in the development of breast cancer.Akt2 regulates expression of the actin-bundling protein palladin RORα suppresses breast tumor invasion by inducing SEMA3F expression Cooperative interactions of PTEN deficiency and RAS activation in melanoma metastasis Cisplatin and PI3kinase inhibition decrease invasion and migration of human ovarian carcinoma cells and regulate matrix-metalloproteinase expression.Protein tyrosine phosphatase 1B deficiency or inhibition delays ErbB2-induced mammary tumorigenesis and protects from lung metastasis.Metabolomic analysis of akt1-mediated muscle hypertrophy in models of diet-induced obesity and age-related fat accumulation.Phosphorylated AKT expression is associated with PIK3CA mutation, low stage, and favorable outcome in 717 colorectal cancers Distinct actions of akt1 on skeletal architecture and function Akt1 deficiency delays tumor progression, vascular invasion, and distant metastasis in a murine model of thyroid cancer Akt isoform-specific signaling in breast cancer: uncovering an anti-migratory role for palladin.Phosphoinositide 3-kinase signaling pathway mediated by p110α regulates invadopodia formation.Epithelioid sarcoma and unclassified sarcoma with epithelioid features: clinicopathological variables, molecular markers, and a new experimental model.MUC1 alters oncogenic events and transcription in human breast cancer cells.Dual role of SnoN in mammalian tumorigenesis Selective signaling by Akt1 controls osteoblast differentiation and osteoblast-mediated osteoclast development.MYC Drives Pten/Trp53-Deficient Proliferation and Metastasis due to IL6 Secretion and AKT Suppression via PHLPP2.The AMPK stress response pathway mediates anoikis resistance through inhibition of mTOR and suppression of protein synthesis.Mathematical Modelling of Molecular Pathways Enabling Tumour Cell Invasion and Migration.MYC suppresses cancer metastasis by direct transcriptional silencing of αv and β3 integrin subunits PTCSC3 Is Involved in Papillary Thyroid Carcinoma Development by Modulating S100A4 Gene Expression.Dichotomy effects of Akt signaling in breast cancer.Defining Akt actions in muscle differentiation.

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Mechanism of Akt1 inhibition of breast cancer cell invasion reveals a protumorigenic role for TSC2.

http://www.wikidata.org/entity/Q34427178

description

2006 nî lūn-bûn

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Mechanism of Akt1 inhibition o ...... protumorigenic role for TSC2.

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Mechanism of Akt1 inhibition o ...... protumorigenic role for TSC2.

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Mechanism of Akt1 inhibition o ...... protumorigenic role for TSC2.

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Mechanism of Akt1 inhibition o ...... protumorigenic role for TSC2.

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Mechanism of Akt1 inhibition o ...... protumorigenic role for TSC2.

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Mechanism of Akt1 inhibition o ...... protumorigenic role for TSC2.

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Proceedings of the National Academy of Sciences of the United States of America

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Mechanism of Akt1 inhibition o ...... protumorigenic role for TSC2.

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Celeste M Nelson

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Derek C Radisky

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Hong Liu

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Hui Zhang

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Jimmie E Fata

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Mina J Bissell

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Richard A Roth

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P2860

The TSC1 tumour suppressor hamartin regulates cell adhesion through ERM proteins and the GTPase Rho

The p38 and MK2 kinase cascade phosphorylates tuberin, the tuberous sclerosis 2 gene product, and enhances its interaction with 14-3-3

Identification and characterization of the interaction between tuberin and 14-3-3zeta

Regulation of TSC2 by 14-3-3 binding

Akt/PKB regulates actin organization and cell motility via Girdin/APE

Rho GTPases and the actin cytoskeleton

Rho GTPases: biochemistry and biology

Cell migration: integrating signals from front to back

Cellular motility driven by assembly and disassembly of actin filaments

A gene-expression signature as a predictor of survival in breast cancer

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