KTI11 and KTI13, Saccharomyces cerevisiae genes controlling sensitivity to G1 arrest induced by Kluyveromyces lactis zymocin.
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Identification of the proteins required for biosynthesis of diphthamide, the target of bacterial ADP-ribosylating toxins on translation elongation factor 2The diphthamide modification pathway from Saccharomyces cerevisiae--revisitedStructure of the Elongator cofactor complex Kti11/Kti13 provides insight into the role of Kti13 in Elongator-dependent tRNA modificationProtein interactions within Saccharomyces cerevisiae Elongator, a complex essential for Kluyveromyces lactis zymocicity.Thio-modification of yeast cytosolic tRNA requires a ubiquitin-related system that resembles bacterial sulfur transfer systems.An early step in wobble uridine tRNA modification requires the Elongator complex.A genome-wide screen identifies genes required for formation of the wobble nucleoside 5-methoxycarbonylmethyl-2-thiouridine in Saccharomyces cerevisiae.Functional genomics of genes with small open reading frames (sORFs) in S. cerevisiae.The yeast elongator histone acetylase requires Sit4-dependent dephosphorylation for toxin-target capacity.The amidation step of diphthamide biosynthesis in yeast requires DPH6, a gene identified through mining the DPH1-DPH5 interaction networkThe biosynthesis and biological function of diphthamideA dominant-negative approach that prevents diphthamide formation confers resistance to Pseudomonas exotoxin A and diphtheria toxintRNAGlu wobble uridine methylation by Trm9 identifies Elongator's key role for zymocin-induced cell death in yeast.Mannosyl-diinositolphospho-ceramide, the major yeast plasma membrane sphingolipid, governs toxicity of Kluyveromyces lactis zymocin.Saccharomyces cerevisiae RNA polymerase II is affected by Kluyveromyces lactis zymocin.DRL1, a homolog of the yeast TOT4/KTI12 protein, has a function in meristem activity and organ growth in plants.Comparative analysis of the conserved functions of Arabidopsis DRL1 and yeast KTI12.The elongata mutants identify a functional Elongator complex in plants with a role in cell proliferation during organ growth.Allele-specific suppressors of lin-1(R175Opal) identify functions of MOC-3 and DPH-3 in tRNA modification complexes in Caenorhabditis elegansSilencing of diphthamide synthesis 3 (Dph3) reduces metastasis of murine melanoma.Dph3, a small protein required for diphthamide biosynthesis, is essential in mouse developmentLoss of anticodon wobble uridine modifications affects tRNA(Lys) function and protein levels in Saccharomyces cerevisiae.Insights into molecular plasticity in protein complexes from Trm9-Trm112 tRNA modifying enzyme crystal structure.Anticodon nuclease encoding virus-like elements in yeast.Dph3 is an electron donor for Dph1-Dph2 in the first step of eukaryotic diphthamide biosynthesis.Wobble uridine modifications-a reason to live, a reason to die?!Yeast Elongator protein Elp1p does not undergo proteolytic processing in exponentially growing cells.Use of a Yeast tRNase Killer Toxin to Diagnose Kti12 Motifs Required for tRNA Modification by Elongator.A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin.Human Elongator complex is involved in cell cycle and suppresses cell growth in 293T human embryonic kidney cells.A mutated dph3 gene causes sensitivity of Schizosaccharomyces pombe cells to cytotoxic agents.Monitoring the 5-methoxycarbonylmethyl-2-thiouridine (mcm5s2U) modification in eukaryotic tRNAs via the gamma-toxin endonuclease.An iron-sulfur cluster domain in Elp3 important for the structural integrity of elongator.Importance of diphthamide modified EF2 for translational accuracy and competitive cell growth in yeast
P2860
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P2860
KTI11 and KTI13, Saccharomyces cerevisiae genes controlling sensitivity to G1 arrest induced by Kluyveromyces lactis zymocin.
description
2002 nî lūn-bûn
@nan
2002 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
name
KTI11 and KTI13, Saccharomyces ...... Kluyveromyces lactis zymocin.
@ast
KTI11 and KTI13, Saccharomyces ...... Kluyveromyces lactis zymocin.
@en
type
label
KTI11 and KTI13, Saccharomyces ...... Kluyveromyces lactis zymocin.
@ast
KTI11 and KTI13, Saccharomyces ...... Kluyveromyces lactis zymocin.
@en
prefLabel
KTI11 and KTI13, Saccharomyces ...... Kluyveromyces lactis zymocin.
@ast
KTI11 and KTI13, Saccharomyces ...... Kluyveromyces lactis zymocin.
@en
P2860
P1476
KTI11 and KTI13, Saccharomyces ...... Kluyveromyces lactis zymocin.
@en
P2093
Lars Fichtner
Raffael Schaffrath
P2860
P304
P356
10.1046/J.1365-2958.2002.02928.X
P407
P577
2002-05-01T00:00:00Z