Mutations of the serine protease CAP1/Prss8 lead to reduced embryonic viability, skin defects, and decreased ENaC activity.
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Comparative Analysis of Muscle Transcriptome between Pig Genotypes Identifies Genes and Regulatory Mechanisms Associated to Growth, Fatness and MetabolismThe membrane-anchored serine protease prostasin (CAP1/PRSS8) supports epidermal development and postnatal homeostasis independent of its enzymatic activity.Prostasin may contribute to chemoresistance, repress cancer cells in ovarian cancer, and is involved in the signaling pathways of CASP/PAK2-p34/actin.Matriptase zymogen supports epithelial development, homeostasis and regenerationColon-specific deletion of epithelial sodium channel causes sodium loss and aldosterone resistanceThe retarded hair growth (rhg) mutation in mice is an allele of ornithine aminotransferase (Oat).Prostasin interacts with the epithelial Na+ channel and facilitates cleavage of the γ-subunit by a second proteaseThe channel-activating protease CAP1/Prss8 is required for placental labyrinth maturation.The juvenile alopecia mutation (jal) maps to mouse Chromosome 2, and is an allele of GATA binding protein 3 (Gata3).Functional analysis of a missense mutation in the serine protease inhibitor SPINT2 associated with congenital sodium diarrhea.Epithelial Sodium Channel-Mediated Sodium Transport Is Not Dependent on the Membrane-Bound Serine Protease CAP2/Tmprss4.PSP94, an upstream signaling mediator of prostasin found highly elevated in ovarian cancer.Prostasin is required for matriptase activation in intestinal epithelial cells to regulate closure of the paracellular pathway.Membrane-anchored proteases in endothelial cell biology.The Transmembrane Serine Protease HAT-like 4 Is Important for Epidermal Barrier Function to Prevent Body Fluid Loss.Epidermal barriersUrinary serine proteases and activation of ENaC in kidney--implications for physiological renal salt handling and hypertensive disorders with albuminuria.The function and regulation of acid-sensing ion channels (ASICs) and the epithelial Na(+) channel (ENaC): IUPHAR Review 19.Delineation of proteolytic and non-proteolytic functions of the membrane-anchored serine protease prostasin.Cutting it out: ENaC processing in the human nephron.Altered Prostasin (CAP1/Prss8) Expression Favors Inflammation and Tissue Remodeling in DSS-induced Colitis.Loss of HAI-2 in mice with decreased prostasin activity leads to an early-onset intestinal failure resembling congenital tufting enteropathy.
P2860
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P2860
Mutations of the serine protease CAP1/Prss8 lead to reduced embryonic viability, skin defects, and decreased ENaC activity.
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2012 nî lūn-bûn
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2012 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2012 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
name
Mutations of the serine protea ...... , and decreased ENaC activity.
@ast
Mutations of the serine protea ...... , and decreased ENaC activity.
@en
type
label
Mutations of the serine protea ...... , and decreased ENaC activity.
@ast
Mutations of the serine protea ...... , and decreased ENaC activity.
@en
prefLabel
Mutations of the serine protea ...... , and decreased ENaC activity.
@ast
Mutations of the serine protea ...... , and decreased ENaC activity.
@en
P2093
P1476
Mutations of the serine protea ...... , and decreased ENaC activity.
@en
P2093
Anna Keppner
Anne-Marie Merillat
Carole Planès
Chloé Sergi
Edith Hummler
Justyna Iwaszkiewicz
Nadia Randrianarison
Nicole Fowler-Jaeger
Simona Frateschi
Sumedha Malsure
P304
P356
10.1016/J.AJPATH.2012.05.007
P407
P577
2012-06-13T00:00:00Z