Prostasin is required for matriptase activation in intestinal epithelial cells to regulate closure of the paracellular pathway.
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Inhibition of Matriptase Activity Results in Decreased Intestinal Epithelial Monolayer Integrity In VitroThe membrane-anchored serine protease prostasin (CAP1/PRSS8) supports epidermal development and postnatal homeostasis independent of its enzymatic activity.Matriptase zymogen supports epithelial development, homeostasis and regenerationThe protease inhibitor HAI-2, but not HAI-1, regulates matriptase activation and shedding through prostasin.The Cap1-claudin-4 regulatory pathway is important for renal chloride reabsorption and blood pressure regulation.Detection of active matriptase using a biotinylated chloromethyl ketone peptideIbuprofen regulates the expression and function of membrane-associated serine proteases prostasin and matriptase.Natural Endogenous Human Matriptase and Prostasin Undergo Zymogen Activation via Independent Mechanisms in an Uncoupled Manner.Targeting the membrane-anchored serine protease testisin with a novel engineered anthrax toxin prodrug to kill tumor cells and reduce tumor burden.Viral interactions with the blood-brain barrier: old dog, new tricksA matriptase-prostasin reciprocal zymogen activation complex with unique features: prostasin as a non-enzymatic co-factor for matriptase activation.Matriptase-mediated cleavage of EpCAM destabilizes claudins and dysregulates intestinal epithelial homeostasis.Signaling pathways induced by serine proteases to increase intestinal epithelial barrier function.The serine protease-mediated increase in intestinal epithelial barrier function is dependent on occludin and requires an intact tight junction.Interaction exists between matriptase inhibitors and intestinal epithelial cells.Hepatocyte growth factor activator inhibitor type 1 maintains the assembly of keratin into desmosomes in keratinocytes by regulating protease-activated receptor 2-dependent p38 signaling.Delineation of proteolytic and non-proteolytic functions of the membrane-anchored serine protease prostasin.Coagulation signaling to epithelia.Protease signaling regulates apical cell extrusion, cell contacts, and proliferation in epithelia.Inflammatory cytokines down-regulate the barrier-protective prostasin-matriptase proteolytic cascade early in experimental colitis.Deregulated hepsin protease activity confers oncogenicity by concomitantly augmenting HGF/MET signalling and disrupting epithelial cohesion.Intestinal regulation of suppression of tumorigenicity 14 (ST14) and serine peptidase inhibitor, Kunitz type -1 (SPINT1) by transcription factor CDX2
P2860
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P2860
Prostasin is required for matriptase activation in intestinal epithelial cells to regulate closure of the paracellular pathway.
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2013年の論文
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2013年論文
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2013年論文
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2013年論文
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name
Prostasin is required for matr ...... e of the paracellular pathway.
@ast
Prostasin is required for matr ...... e of the paracellular pathway.
@en
type
label
Prostasin is required for matr ...... e of the paracellular pathway.
@ast
Prostasin is required for matr ...... e of the paracellular pathway.
@en
prefLabel
Prostasin is required for matr ...... e of the paracellular pathway.
@ast
Prostasin is required for matr ...... e of the paracellular pathway.
@en
P2093
P2860
P356
P1476
Prostasin is required for matr ...... e of the paracellular pathway.
@en
P2093
Antoine Désilets
Erik W Martin
Kathryn H Driesbaugh
Marguerite S Buzza
Richard Leduc
Toni M Antalis
P2860
P304
10328-10337
P356
10.1074/JBC.M112.443432
P407
P577
2013-02-26T00:00:00Z