Identification of chemosensitivity nodes for vinblastine through small interfering RNA high-throughput screens.
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Identification of druggable targets for radiation mitigation using a small interfering RNA screening assayPhenotypic screening reveals topoisomerase I as a breast cancer stem cell therapeutic targetInhibition of phosphatidylinositol 3-kinase/AKT signaling by NVP-BKM120 promotes ABT-737-induced toxicity in a caspase-dependent manner through mitochondrial dysfunction and DNA damage response in established and primary cultured glioblastoma cells.Alkylation sensitivity screens reveal a conserved cross-species functionome.ABT-737 synergizes with bortezomib to induce apoptosis, mediated by Bid cleavage, Bax activation, and mitochondrial dysfunction in an Akt-dependent context in malignant human glioma cell lines.Cucurbitacin-I inhibits Aurora kinase A, Aurora kinase B and survivin, induces defects in cell cycle progression and promotes ABT-737-induced cell death in a caspase-independent manner in malignant human glioma cellsYM-155 potentiates the effect of ABT-737 in malignant human glioma cells via survivin and Mcl-1 downregulation in an EGFR-dependent context.Survivin inhibitor YM-155 sensitizes tumor necrosis factor- related apoptosis-inducing ligand-resistant glioma cells to apoptosis through Mcl-1 downregulation and by engaging the mitochondrial death pathwayStimuli-responsive hybrid nanocarriers developed by controllable integration of hyperbranched PEI with mesoporous silica nanoparticles for sustained intracellular siRNA delivery.Novel siRNA delivery strategy: a new "strand" in CNS translational medicine?Embracing synthetic lethality of novel anticancer therapies.Microtubule destabilising agents: far more than just antimitotic anticancer drugs.Mitochondrial dysfunction RAD51, and Ku80 proteolysis promote apoptotic effects of Dinaciclib in Bcl-xL silenced cells.Survivin inhibitor YM155 induces mitochondrial dysfunction, autophagy, DNA damage and apoptosis in Bcl-xL silenced glioma cell lines.
P2860
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P2860
Identification of chemosensitivity nodes for vinblastine through small interfering RNA high-throughput screens.
description
2011 nî lūn-bûn
@nan
2011 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
Identification of chemosensiti ...... g RNA high-throughput screens.
@ast
Identification of chemosensiti ...... g RNA high-throughput screens.
@en
type
label
Identification of chemosensiti ...... g RNA high-throughput screens.
@ast
Identification of chemosensiti ...... g RNA high-throughput screens.
@en
prefLabel
Identification of chemosensiti ...... g RNA high-throughput screens.
@ast
Identification of chemosensiti ...... g RNA high-throughput screens.
@en
P2093
P2860
P356
P1476
Identification of chemosensiti ...... g RNA high-throughput screens.
@en
P2093
Carolyn A Kitchens
Ian F Pollack
Peter R McDonald
P2860
P304
P356
10.1124/JPET.111.184879
P407
P577
2011-08-31T00:00:00Z