about
Automated high-content live animal drug screening using C. elegans expressing the aggregation prone serpin α1-antitrypsin ZMKP-8, a novel MAPK phosphatase that inhibits p38 kinaseProtein-tyrosine phosphatase 4A3 (PTP4A3) promotes vascular endothelial growth factor signaling and enables endothelial cell motility.Identification of epidermal growth factor receptor as a target of Cdc25A protein phosphataseStrategies for discovery of small molecule radiation protectors and radiation mitigatorsEvaluation of potential ionizing irradiation protectors and mitigators using clonogenic survival of human umbilical cord blood hematopoietic progenitor cellsIdentification of potent chemotypes targeting Leishmania major using a high-throughput, low-stringency, computationally enhanced, small molecule screenA target-based high throughput screen yields Trypanosoma brucei hexokinase small molecule inhibitors with antiparasitic activityDiscovery of diverse small molecule chemotypes with cell-based PKD1 inhibitory activity.Optimization of pyrazole-containing 1,2,4-triazolo-[3,4-b]thiadiazines, a new class of STAT3 pathway inhibitorsPhotooxygenation of an amino-thienopyridone yields a more potent PTP4A3 inhibitor.Development and Implementation of a High-Throughput High-Content Screening Assay to Identify Inhibitors of Androgen Receptor Nuclear Localization in Castration-Resistant Prostate Cancer Cells.Drugging Undruggable Molecular Cancer Targets.Direct inhibition of c-Myc-Max heterodimers by celastrol and celastrol-inspired triterpenoids.HCS campaign to identify selective inhibitors of IL-6-induced STAT3 pathway activation in head and neck cancer cell linesSynthesis and biological evaluation of 3-aminoisoquinolin-1(2H)-one based inhibitors of the dual-specificity phosphatase Cdc25B.2-Guanidinoquinazolines as new inhibitors of the STAT3 pathway.Identification of druggable targets for radiation mitigation using a small interfering RNA screening assayMolecular biology and anticancer drug discovery.High-content pSTAT3/1 imaging assays to screen for selective inhibitors of STAT3 pathway activation in head and neck cancer cell lines.Pharmacologic profiling of phosphoinositide 3-kinase inhibitors as mitigators of ionizing radiation-induced cell deathDrug discovery algorithm for cutaneous leishmaniasis.Effector kinase coupling enables high-throughput screens for direct HIV-1 Nef antagonists with antiretroviral activity.Development and validation of a high-content screening assay to identify inhibitors of cytoplasmic dynein-mediated transport of glucocorticoid receptor to the nucleus.Phenotypic screening reveals topoisomerase I as a breast cancer stem cell therapeutic targetTargeted deletion of the metastasis-associated phosphatase Ptp4a3 (PRL-3) suppresses murine colon cancer.Identification of chemosensitivity nodes for vinblastine through small interfering RNA high-throughput screens.Design, Synthesis, and Biological Evaluation of PKD Inhibitors.The substrate recognition domains of the N-end rule pathway.Auranofin is an apoptosis-simulating agent with in vitro and in vivo anti-leishmanial activity.Investigational inhibitors of PTP4A3 phosphatase as antineoplastic agents.Mitotic slippage in non-cancer cells induced by a microtubule disruptor, disorazole C1.Dual G1 and G2 phase inhibition by a novel, selective Cdc25 inhibitor 6-chloro-7-[corrected](2-morpholin-4-ylethylamino)-quinoline-5,8-dione.Small molecule regulation of phosphatase-dependent cell signaling pathways.Implementation of a 220,000-compound HCS campaign to identify disruptors of the interaction between p53 and hDM2 and characterization of the confirmed hits.Discovery and characterization of novel small molecule inhibitors of human Cdc25B dual specificity phosphatase.The benzo[c]phenanthridine alkaloid, sanguinarine, is a selective, cell-active inhibitor of mitogen-activated protein kinase phosphatase-1.Chemical complementation: a definitive phenotypic strategy for identifying small molecule inhibitors of elusive cellular targets.Cellular analysis of disorazole C and structure-activity relationship of analogs of the natural product.Synthesis and biological activity of a focused library of mitogen-activated protein kinase phosphatase inhibitors.
P50
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P50
description
researcher
@en
wetenschapper
@nl
հետազոտող
@hy
name
John S Lazo
@ast
John S Lazo
@en
John S Lazo
@es
John S Lazo
@nl
type
label
John S Lazo
@ast
John S Lazo
@en
John S Lazo
@es
John S Lazo
@nl
prefLabel
John S Lazo
@ast
John S Lazo
@en
John S Lazo
@es
John S Lazo
@nl
P106
P31
P496
0000-0002-0645-4025