Single enantiomer of YK-4-279 demonstrates specificity in targeting the oncogene EWS-FLI1. - Wikidata - wikimedia - TriplyDB

Single enantiomer of YK-4-279 demonstrates specificity in targeting the oncogene EWS-FLI1.

Single enantiomer of YK-4-279 demonstrates specificity in targeting the oncogene EWS-FLI1.

http://www.wikidata.org/entity/Q30427325

about

Catalytic asymmetric synthesis of biologically important 3-hydroxyoxindoles: an update The RNA helicase A in malignant transformation A small molecule inhibitor of ETV1, YK-4-279, prevents prostate cancer growth and metastasis in a mouse xenograft model Potential approaches to the treatment of Ewing's sarcoma Recent advances in targeted therapy for Ewing sarcoma Lineage of origin in rhabdomyosarcoma informs pharmacological response New strategies in ewing sarcoma: lost in translation?Pathological unfoldomics of uncontrolled chaos: intrinsically disordered proteins and human diseases Assemblages: functional units formed by cellular phase separation A small molecule that binds and inhibits the ETV1 transcription factor oncoprotein Epidemiology and therapies for metastatic sarcoma Morphoproteomic profiling of the mammalian target of rapamycin (mTOR) signaling pathway in desmoplastic small round cell tumor (EWS/WT1), Ewing's sarcoma (EWS/FLI1) and Wilms' tumor(WT1)Polycation-π interactions are a driving force for molecular recognition by an intrinsically disordered oncoprotein family.RNA helicase A activity is inhibited by oncogenic transcription factor EWS-FLI1.Epigenetic reprogramming and re-differentiation of a Ewing sarcoma cell line Oncogenic fusion protein EWS-FLI1 is a network hub that regulates alternative splicing.Synthesis and structure-activity relationship studies of small molecule disruptors of EWS-FLI1 interactions in Ewing's sarcoma.Targeted therapies for advanced Ewing sarcoma family of tumors.PI3K/AKT signaling modulates transcriptional expression of EWS/FLI1 through specificity protein 1.YK-4-279 effectively antagonizes EWS-FLI1 induced leukemia in a transgenic mouse model.Ewing's sarcoma: overcoming the therapeutic plateau.Pharmacokinetic modeling optimizes inhibition of the 'undruggable' EWS-FLI1 transcription factor in Ewing Sarcoma.Proof-of-concept rare cancers in drug development: the case for rhabdomyosarcoma.Xenograft and genetically engineered mouse model systems of osteosarcoma and Ewing's sarcoma: tumor models for cancer drug discovery.Recent advances in the structural molecular biology of Ets transcription factors: interactions, interfaces and inhibition.Blocking the road, stopping the engine or killing the driver? Advances in targeting EWS/FLI-1 fusion in Ewing sarcoma as novel therapy.Drugging the 'undruggable' cancer targets.The small molecule inhibitor YK-4-279 disrupts mitotic progression of neuroblastoma cells, overcomes drug resistance and synergizes with inhibitors of mitosis Ewing sarcoma inhibition by disruption of EWSR1-FLI1 transcriptional activity and reactivation of p53.ETV1 positively regulates transcription of tumor suppressor ARF.Antiviral activity of diarylheptanoid stereoisomers against respiratory syncytial virus in vitro and in vivo.EWS-FLI1 and RNA helicase A interaction inhibitor YK-4-279 inhibits growth of neuroblastoma.

P2860

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P2860

Single enantiomer of YK-4-279 demonstrates specificity in targeting the oncogene EWS-FLI1.

http://www.wikidata.org/entity/Q30427325

description

2012 nî lūn-bûn

@nan

2012 թուականի Փետրուարին հրատարակուած գիտական յօդուած

@hyw

2012 թվականի փետրվարին հրատարակված գիտական հոդված

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2012年の論文

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2012年論文

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2012年論文

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2012年論文

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2012年論文

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2012年論文

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2012年论文

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name

Single enantiomer of YK-4-279 ...... rgeting the oncogene EWS-FLI1.

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Single enantiomer of YK-4-279 ...... rgeting the oncogene EWS-FLI1.

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type

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Single enantiomer of YK-4-279 ...... rgeting the oncogene EWS-FLI1.

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Single enantiomer of YK-4-279 ...... rgeting the oncogene EWS-FLI1.

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prefLabel

Single enantiomer of YK-4-279 ...... rgeting the oncogene EWS-FLI1.

@ast

Single enantiomer of YK-4-279 ...... rgeting the oncogene EWS-FLI1.

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Single enantiomer of YK-4-279 ...... rgeting the oncogene EWS-FLI1.

@en

P2093

Aykut Üren

http://www.w3.org/2001/XMLSchema#string

Christina L Kobs

http://www.w3.org/2001/XMLSchema#string

Hayriye V Erkizan

http://www.w3.org/2001/XMLSchema#string

Jeffrey A Toretsky

http://www.w3.org/2001/XMLSchema#string

Julie S Barber-Rotenberg

http://www.w3.org/2001/XMLSchema#string

Lauren J Scher

http://www.w3.org/2001/XMLSchema#string

Milton L Brown

http://www.w3.org/2001/XMLSchema#string

Natalie L South

http://www.w3.org/2001/XMLSchema#string

Perrer N Tosso

http://www.w3.org/2001/XMLSchema#string

Philip J Monroe

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P2860

Molecular characterization of mitochondrial apoptosis-inducing factor

Gene fusion with an ETS DNA-binding domain caused by chromosome translocation in human tumours

A variant Ewing's sarcoma translocation (7;22) fuses the EWS gene to the ETS gene ETV1

A new member of the ETS family fused to EWS in Ewing tumors

A short history of SHELX

Improved methods for building protein models in electron density maps and the location of errors in these models

Recurrent fusion of TMPRSS2 and ETS transcription factor genes in prostate cancer.

HKL-3000: the integration of data reduction and structure solution--from diffraction images to an initial model in minutes

Intrinsically disordered protein

Identification of Omi/HtrA2 as a mitochondrial apoptotic serine protease that disrupts inhibitor of apoptosis protein-caspase interaction

P304

172-182

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P31

scholarly article

P356

10.18632/ONCOTARGET.454

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P407

P433

2

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P478

3

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Maksymilian Chruszcz

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2012-02-01T00:00:00Z

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221882034

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22383402

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3326647

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