about
TRIM5α associates with proteasomal subunits in cells while in complex with HIV-1 virionsTRIM5 is an innate immune sensor for the retrovirus capsid latticeTRIM protein-mediated regulation of inflammatory and innate immune signaling and its association with antiretroviral activityTRIM5α and Species Tropism of HIV/SIVHIV type 1 Gag as a target for antiviral therapyImpact of TRIM5α in vivoEvolution of foamy viruses: the most ancient of all retrovirusesCoupling viruses to dynein and kinesin-1Evolutionary conflicts between viruses and restriction factors shape immunityFusion of mature HIV-1 particles leads to complete release of a gag-GFP-based content marker and raises the intraviral pHStructure of the rhesus monkey TRIM5 PRYSPRY domain, the HIV capsid recognition moduleStructural insight into HIV-1 capsid recognition by rhesus TRIM5Diverse HIV viruses are targeted by a conformationally dynamic antiviralGain-of-Sensitivity Mutations in a Trim5-Resistant Primary Isolate of Pathogenic SIV Identify Two Independent Conserved Determinants of Trim5α SpecificityA unique spumavirus Gag N-terminal domain with functional properties of orthoretroviral matrix and capsidThe tripartite motif coiled-coil is an elongated antiparallel hairpin dimer.Structural studies of postentry restriction factors reveal antiparallel dimers that enable avid binding to the HIV-1 capsid latticeRhesus TRIM5α disrupts the HIV-1 capsid at the inter-hexamer interfacesFates of retroviral core components during unrestricted and TRIM5-restricted infectionRhesus monkey TRIM5α SPRY domain recognizes multiple epitopes that span several capsid monomers on the surface of the HIV-1 mature viral coreIntrinsic cellular defenses against human immunodeficiency virusesAn evolutionary screen highlights canonical and noncanonical candidate antiviral genes within the primate TRIM gene familyApparent effect of rabbit endogenous lentivirus type K acquisition on retrovirus restriction by lagomorph Trim5αsMechanism of TRIM25 Catalytic Activation in the Antiviral RIG-I Pathway.Primate TRIM5 proteins form hexagonal nets on HIV-1 capsids.Mechanism of B-box 2 domain-mediated higher-order assembly of the retroviral restriction factor TRIM5α.Coarse-grained simulation reveals key features of HIV-1 capsid self-assembly.Closing the net on retrovirusesSIV replication in human cellsPandemic influenza A viruses escape from restriction by human MxA through adaptive mutations in the nucleoprotein.Ordered assembly of murine leukemia virus capsid protein on lipid nanotubes directs specific binding by the restriction factor, Fv1Recruitment and dynamics of proteasome association with rhTRIM5α cytoplasmic complexes during HIV-1 infection.TRIM15 is a focal adhesion protein that regulates focal adhesion disassembly.Functional evidence for the involvement of microtubules and dynein motor complexes in TRIM5α-mediated restriction of retroviruses.Stabilized human TRIM5α protects human T cells from HIV-1 infection.Host and viral determinants of Mx2 antiretroviral activityStudy of Sylvilagus rabbit TRIM5α species-specific domain: how ancient endoviruses could have shaped the antiviral repertoire in Lagomorpha.Restriction of HIV-1 by rhesus TRIM5α is governed by alpha helices in the Linker2 region.HERV-K(HML-2), a seemingly silent subtenant - but still waters run deep.Delaying reverse transcription does not increase sensitivity of HIV-1 to human TRIM5α.
P2860
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P2860
description
2010 nî lūn-bûn
@nan
2010 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Hexagonal assembly of a restricting TRIM5alpha protein
@ast
Hexagonal assembly of a restricting TRIM5alpha protein
@en
type
label
Hexagonal assembly of a restricting TRIM5alpha protein
@ast
Hexagonal assembly of a restricting TRIM5alpha protein
@en
prefLabel
Hexagonal assembly of a restricting TRIM5alpha protein
@ast
Hexagonal assembly of a restricting TRIM5alpha protein
@en
P2093
P2860
P356
P1476
Hexagonal assembly of a restricting TRIM5alpha protein
@en
P2093
Barbie K Ganser-Pornillos
Joseph G Sodroski
Mark Yeager
Owen Pornillos
Wesley I Sundquist
P2860
P304
P356
10.1073/PNAS.1013426108
P407
P577
2010-12-27T00:00:00Z