Discovery of N-{4-[(3-hydroxyphenyl)-3-methylpiperazin-1-yl]methyl-2-methylpropyl}-4-phenoxybenzamide analogues as selective kappa opioid receptor antagonists - Wikidata - wikimedia - TriplyDB

Discovery of N-{4-[(3-hydroxyphenyl)-3-methylpiperazin-1-yl]methyl-2-methylpropyl}-4-phenoxybenzamide analogues as selective kappa opioid receptor antagonists

Discovery of N-{4-[(3-hydroxyphenyl)-3-methylpiperazin-1-yl]methyl-2-methylpropyl}-4-phenoxybenzamide analogues as selective kappa opioid receptor antagonists

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Synthesis of Kappa Opioid Antagonists Based On Pyrrolo[1,2-α]quinoxalinones Using an N-Arylation/Condensation/Oxidation Reaction Sequence.

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Discovery of N-{4-[(3-hydroxyphenyl)-3-methylpiperazin-1-yl]methyl-2-methylpropyl}-4-phenoxybenzamide analogues as selective kappa opioid receptor antagonists

http://www.wikidata.org/entity/Q30436776

description

2013 nî lūn-bûn

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2013 թուականի Մայիսին հրատարակուած գիտական յօդուած

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2013 թվականի մայիսին հրատարակված գիտական հոդված

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2013年の論文

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2013年論文

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2013年論文

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2013年論文

@zh-hk

2013年論文

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2013年論文

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2013年论文

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name

Discovery of N-{4-[(3-hydroxyp ...... pa opioid receptor antagonists

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Discovery of N-{4-[(3-hydroxyp ...... pa opioid receptor antagonists

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type

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Discovery of N-{4-[(3-hydroxyp ...... pa opioid receptor antagonists

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Discovery of N-{4-[(3-hydroxyp ...... pa opioid receptor antagonists

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Discovery of N-{4-[(3-hydroxyp ...... pa opioid receptor antagonists

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Discovery of N-{4-[(3-hydroxyp ...... pa opioid receptor antagonists

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Journal of Medicinal Chemistry

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Discovery of N-{4-[(3-hydroxyp ...... pa opioid receptor antagonists

@en

P2093

Brian P Gilmour

http://www.w3.org/2001/XMLSchema#string

Chad M Kormos

http://www.w3.org/2001/XMLSchema#string

Chunyang Jin

http://www.w3.org/2001/XMLSchema#string

F Ivy Carroll

http://www.w3.org/2001/XMLSchema#string

Hernán A Navarro

http://www.w3.org/2001/XMLSchema#string

James B Thomas

http://www.w3.org/2001/XMLSchema#string

Juan Pablo Cueva

http://www.w3.org/2001/XMLSchema#string

Lawrence E Brieaddy

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S Wayne Mascarella

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Scott P Runyon

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P2860

Structure of the human κ-opioid receptor in complex with JDTic

Stress-induced reinstatement of cocaine seeking is mediated by the kappa opioid system

Pharmacological evidence for a motivational role of kappa-opioid systems in ethanol dependence

Kappa opioid receptor antagonism and prodynorphin gene disruption block stress-induced behavioral responses

Differential effects of the novel kappa opioid receptor antagonist, JDTic, on reinstatement of cocaine-seeking induced by footshock stressors vs cocaine primes and its antidepressant-like effects in rats

Rapid calculation of polar molecular surface area and its application to the prediction of transport phenomena. 2. Prediction of blood-brain barrier penetration.

Identification of an opioid kappa receptor subtype-selective N-substituent for (+)-(3R,4R)-dimethyl-4-(3-hydroxyphenyl)piperidine.

Computational methods for the prediction of 'drug-likeness'

Identification of the first trans-(3R,4R)- dimethyl-4-(3-hydroxyphenyl)piperidine derivative to possess highly potent and selective opioid kappa receptor antagonist activity.

Antidepressant-like effects of kappa-opioid receptor antagonists in the forced swim test in rats.

P304

4551-4567

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scholarly article

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10.1021/JM400275H

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P433

11

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56

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2013-05-16T00:00:00Z

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23651437

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3701944

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