Identification of an opioid kappa receptor subtype-selective N-substituent for (+)-(3R,4R)-dimethyl-4-(3-hydroxyphenyl)piperidine.

Identification of an opioid kappa receptor subtype-selective N-substituent for (+)-(3R,4R)-dimethyl-4-(3-hydroxyphenyl)piperidine.

Item
http://www.wikidata.org/entity/Q31952267
Kappa opioid antagonists: past successes and future prospectsFlavonoids as opioid receptor ligands: identification and preliminary structure-activity relationshipsDiscovery of the first small-molecule opioid pan antagonist with nanomolar affinity at mu, delta, kappa, and nociceptin opioid receptorsCharacterization of BU09059: a novel potent selective κ-receptor antagonistDiscovery of N-{4-[(3-hydroxyphenyl)-3-methylpiperazin-1-yl]methyl-2-methylpropyl}-4-phenoxybenzamide analogues as selective kappa opioid receptor antagonistsAnalogues of (3R)-7-hydroxy-N-[(1S)-1-{[(3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethyl-1-piperidinyl]methyl}-2-methylpropyl)-1,2,3,4-tetrahydro-3-isoquinolinecarboxamide (JDTic). Synthesis and in vitro and in vivo opioid receptor antagonist activityIn vitro and direct in vivo testing of mixture-based combinatorial libraries for the identification of highly active and specific opiate ligands.Effect of the 3- and 4-methyl groups on the opioid receptor properties of N-substituted trans-3,4-dimethyl-4-(3-hydroxyphenyl)piperidines.N-substituted cis-4a-(3-hydroxyphenyl)-8a-methyloctahydroisoquinolines are opioid receptor pure antagonistsMajor Depressive Disorder and Kappa Opioid Receptor Antagonists.Crystal structure of (4-hy-droxy-piperidin-1-yl)(4-methyl-phen-yl)methanone.Development of κ opioid receptor antagonists.Natural products as tools for neuroscience: discovery and development of novel agents to treat drug abuse1-Substituted 4-(3-Hydroxyphenyl)piperazines Are Pure Opioid Receptor AntagonistsSynthesis and in vitro opioid receptor functional antagonism of methyl-substituted analogues of (3R)-7-hydroxy-N-[(1S)-1-{[(3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethyl-1-piperidinyl]methyl}-2-methylpropyl]-1,2,3,4-tetrahydro-3-isoquinolinecarboxamide (JOpioid peptide receptor studies. 15. Relative efficacy of 4-[(N-allyl-3-methyl-4-piperidinyl)phenylamino]-N,N-diethylbenzamide and related compounds at the cloned human delta-opioid receptor.Opioid ligands with mixed properties from substituted enantiomeric N-phenethyl-5-phenylmorphans. Synthesis of a micro-agonist delta-antagonist and delta-inverse agonists.
P2860

Identification of an opioid kappa receptor subtype-selective N-substituent for (+)-(3R,4R)-dimethyl-4-(3-hydroxyphenyl)piperidine.

Item
http://www.wikidata.org/entity/Q31952267
description
1998 nî lūn-bûn
@nan
1998 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
1998 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
1998年の論文
@ja
1998年論文
@yue
1998年論文
@zh-hant
1998年論文
@zh-hk
1998年論文
@zh-mo
1998年論文
@zh-tw
1998年论文
@wuu
name
Identification of an opioid ka ...... 4-(3-hydroxyphenyl)piperidine.
@ast
Identification of an opioid ka ...... 4-(3-hydroxyphenyl)piperidine.
@en
type
label
Identification of an opioid ka ...... 4-(3-hydroxyphenyl)piperidine.
@ast
Identification of an opioid ka ...... 4-(3-hydroxyphenyl)piperidine.
@en
prefLabel
Identification of an opioid ka ...... 4-(3-hydroxyphenyl)piperidine.
@ast
Identification of an opioid ka ...... 4-(3-hydroxyphenyl)piperidine.
@en
P1433
P1476
P2093
P304
P31
P356
P407
P433
P478
P577
P698
P921
P356
P1433
P1476
Identification of an opioid ka ...... 4-(3-hydroxyphenyl)piperidine.
@en
P2093
P304
P31
P356
P407
P433
P478
P577
P698
P921