A high throughput, whole cell screen for small molecule inhibitors of the mitotic spindle checkpoint identifies OM137, a novel Aurora kinase inhibitor
about
Caenorhabditis elegans cyclin B3 is required for multiple mitotic processes including alleviation of a spindle checkpoint-dependent block in anaphase chromosome segregationSmall compound 6-O-angeloylplenolin induces mitotic arrest and exhibits therapeutic potentials in multiple myelomaGlucocorticoids suppress renal cell carcinoma progression by enhancing Na,K-ATPase beta-1 subunit expressionDietary flavonoid fisetin induces a forced exit from mitosis by targeting the mitotic spindle checkpointDissecting the role of MPS1 in chromosome biorientation and the spindle checkpoint through the small molecule inhibitor reversineScreening for small molecule inhibitors of embryonic pathways: sometimes you gotta crack a few eggs.Skp1 in lung cancer: clinical significance and therapeutic efficacy of its small molecule inhibitorsA cell-based assay for screening spindle checkpoint inhibitorsZM447439, the Aurora kinase B inhibitor, suppresses the growth of cervical cancer SiHa cells and enhances the chemosensitivity to cisplatin.Novel pyrimidine-2,4-diamine derivative suppresses the cell viability and spindle assembly checkpoint activity by targeting Aurora kinases.Assessing cell fusion and cytokinesis failure as mechanisms of clone 9 hepatocyte multinucleation in vitro.
P2860
Q21558513-75D191F9-0A87-4D90-8BBE-9DA75375D037Q28478936-50D44101-C209-4CF6-AEE1-9B413120C43BQ28545292-805B6054-5A3C-4B76-8E75-9DEF7EF45F91Q30488012-9876AC89-CEE0-4015-85D4-6B20D52CC2A4Q34026669-4833027B-907B-4FDF-8838-029C99D23FB3Q34133507-F139744B-038D-47BA-8504-D818D27B25BCQ36544267-B7C3473F-E15F-4CD6-AA02-6CD34AF0CE61Q39392895-CDE3F595-4157-4408-98C0-7D8D4523B9CFQ39620050-08BFA2B1-D960-4637-AF0C-40BBE667FF5BQ45717413-C37560CF-2A91-45DD-9038-E432DC34BF46Q50492097-D35F10F7-EC9B-4E3C-B9C6-18E8B5F5001F
P2860
A high throughput, whole cell screen for small molecule inhibitors of the mitotic spindle checkpoint identifies OM137, a novel Aurora kinase inhibitor
description
2009 nî lūn-bûn
@nan
2009 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
A high throughput, whole cell ...... novel Aurora kinase inhibitor
@ast
A high throughput, whole cell ...... novel Aurora kinase inhibitor
@en
type
label
A high throughput, whole cell ...... novel Aurora kinase inhibitor
@ast
A high throughput, whole cell ...... novel Aurora kinase inhibitor
@en
prefLabel
A high throughput, whole cell ...... novel Aurora kinase inhibitor
@ast
A high throughput, whole cell ...... novel Aurora kinase inhibitor
@en
P2860
P50
P1433
P1476
A high throughput, whole cell ...... novel Aurora kinase inhibitor
@en
P2093
Joanna H DeMoe
John R Daum
P2860
P304
P356
10.1158/0008-5472.CAN-08-3133
P407
P577
2009-02-03T00:00:00Z