Plx1 is the 3F3/2 kinase responsible for targeting spindle checkpoint proteins to kinetochores.
about
Identification of novel mitosis regulators through data mining with human centromere/kinetochore proteins as group queriesPhosphorylation- and polo-box-dependent binding of Plk1 to Bub1 is required for the kinetochore localization of Plk1Tex14, a Plk1-regulated protein, is required for kinetochore-microtubule attachment and regulation of the spindle assembly checkpointMyosin phosphatase-targeting subunit 1 regulates mitosis by antagonizing polo-like kinase 1Cep55, a microtubule-bundling protein, associates with centralspindlin to control the midbody integrity and cell abscission during cytokinesisPolo-like kinase 1, on the rise from cell cycle regulation to prostate cancer developmentThe spindle checkpoint and chromosome segregation in meiosisMutations in Drosophila Greatwall/Scant reveal its roles in mitosis and meiosis and interdependence with Polo kinaseMimicking Ndc80 phosphorylation triggers spindle assembly checkpoint signallingDynactin helps target Polo-like kinase 1 to kinetochores via its left-handed beta-helical p27 subunitComplex formation of Plk1 and INCENP required for metaphase-anaphase transitionSpatial exclusivity combined with positive and negative selection of phosphorylation motifs is the basis for context-dependent mitotic signaling.Drosophila Polo regulates the spindle assembly checkpoint through Mps1-dependent BubR1 phosphorylationDeficiency in chromosome congression by the inhibition of Plk1 polo box domain-dependent recognition.Mps1 directs the assembly of Cdc20 inhibitory complexes during interphase and mitosis to control M phase timing and spindle checkpoint signaling.The fate of metaphase kinetochores is weighed in the balance of SUMOylation during S phase.Loading of the 3F3/2 antigen onto kinetochores is dependent on the ordered assembly of the spindle checkpoint proteins.Polo-box domain inhibitor poloxin activates the spindle assembly checkpoint and inhibits tumor growth in vivo.Tension-sensitive Plk1 phosphorylation on BubR1 regulates the stability of kinetochore microtubule interactions.A mechanobiochemical mechanism for monooriented chromosome oscillation in mitosis.Cdk1 phosphorylation of BubR1 controls spindle checkpoint arrest and Plk1-mediated formation of the 3F3/2 epitope.A stringent requirement for Plk1 T210 phosphorylation during K-fiber assembly and chromosome congressionAn integrated mechanobiochemical feedback mechanism describes chromosome motility from prometaphase to anaphase in mitosis.Sequestration of Polo kinase to microtubules by phosphopriming-independent binding to Map205 is relieved by phosphorylation at a CDK site in mitosis.Requirements for protein phosphorylation and the kinase activity of polo-like kinase 1 (Plk1) for the kinetochore function of mitotic arrest deficiency protein 1 (Mad1).Welcome to a new kind of tension: translating kinetochore mechanics into a wait-anaphase signal.Formation of stable attachments between kinetochores and microtubules depends on the B56-PP2A phosphatase.Playing polo during mitosis: PLK1 takes the lead.Inhibitors of Polo-like kinase reveal roles in spindle-pole maintenance.All together now: Polo joins the kinase network controlling the spindle assembly checkpoint in Drosophila.Polo-like kinase 1 facilitates chromosome alignment during prometaphase through BubR1.
P2860
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P2860
Plx1 is the 3F3/2 kinase responsible for targeting spindle checkpoint proteins to kinetochores.
description
2005 nî lūn-bûn
@nan
2005 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
name
Plx1 is the 3F3/2 kinase respo ...... oint proteins to kinetochores.
@ast
Plx1 is the 3F3/2 kinase respo ...... oint proteins to kinetochores.
@en
type
label
Plx1 is the 3F3/2 kinase respo ...... oint proteins to kinetochores.
@ast
Plx1 is the 3F3/2 kinase respo ...... oint proteins to kinetochores.
@en
prefLabel
Plx1 is the 3F3/2 kinase respo ...... oint proteins to kinetochores.
@ast
Plx1 is the 3F3/2 kinase respo ...... oint proteins to kinetochores.
@en
P2860
P356
P1476
Plx1 is the 3F3/2 kinase respo ...... oint proteins to kinetochores.
@en
P2093
Guowei Fang
Oi Kwan Wong
P2860
P304
P356
10.1083/JCB.200502163
P407
P577
2005-08-01T00:00:00Z