Negatively charged residues in the N-terminal of the AID helix confer slow voltage dependent inactivation gating to CaV1.2.

Negatively charged residues in the N-terminal of the AID helix confer slow voltage dependent inactivation gating to CaV1.2.

Item
http://www.wikidata.org/entity/Q30447395
The role of distal S6 hydrophobic residues in the voltage-dependent gating of CaV2.3 channels.Molecular endpoints of Ca2+/calmodulin- and voltage-dependent inactivation of Ca(v)1.3 channelsKinetic properties of the cardiac L-type Ca2+ channel and its role in myocyte electrophysiology: a theoretical investigation.An autism-associated mutation in CaV1.3 channels has opposing effects on voltage- and Ca(2+)-dependent regulation.Disruption of the IS6-AID linker affects voltage-gated calcium channel inactivation and facilitation.Roscovitine, a cyclin-dependent kinase inhibitor, affects several gating mechanisms to inhibit cardiac L-type (Ca(V)1.2) calcium channels.Alanine-scanning mutagenesis defines a conserved energetic hotspot in the CaValpha1 AID-CaVbeta interaction site that is critical for channel modulation.Mutations of nonconserved residues within the calcium channel alpha1-interaction domain inhibit beta-subunit potentiation.Ca2+-binding protein 2 inhibits Ca2+-channel inactivation in mouse inner hair cells.Calmodulin mutations associated with long QT syndrome prevent inactivation of cardiac L-type Ca(2+) currents and promote proarrhythmic behavior in ventricular myocytes.The C-terminal residues in the alpha-interacting domain (AID) helix anchor CaV beta subunit interaction and modulation of CaV2.3 channels.The role of the GX9GX3G motif in the gating of high voltage-activated Ca2+ channels.Inherited Ventricular Arrhythmias: The Role of the Multi-Subunit Structure of the L-Type Calcium Channel Complex.
P2860

Negatively charged residues in the N-terminal of the AID helix confer slow voltage dependent inactivation gating to CaV1.2.

Item
http://www.wikidata.org/entity/Q30447395
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Negatively charged residues in ...... inactivation gating to CaV1.2.
@ast
Negatively charged residues in ...... inactivation gating to CaV1.2.
@en
type
label
Negatively charged residues in ...... inactivation gating to CaV1.2.
@ast
Negatively charged residues in ...... inactivation gating to CaV1.2.
@en
prefLabel
Negatively charged residues in ...... inactivation gating to CaV1.2.
@ast
Negatively charged residues in ...... inactivation gating to CaV1.2.
@en
P1433
P1476
P2093
P2860
P304
P31
P356
P407
P433
P478
P577
P5875
P698
P932
P356
P1433
P1476
Negatively charged residues in ...... inactivation gating to CaV1.2.
@en
P2093
P2860
P304
P31
P356
10.1529/BIOPHYSJ.104.045559
P407
P433
P478
P577
P5875
P698
P932