Ultra-slow inactivation in mu1 Na+ channels is produced by a structural rearrangement of the outer vestibule
about
Crystal structure of an orthologue of the NaChBac voltage-gated sodium channel.A molecular switch between the outer and the inner vestibules of the voltage-gated Na+ channelStructure and function of voltage-gated sodium channels at atomic resolution.Exploring the structure of the voltage-gated Na+ channel by an engineered drug access pathway to the receptor site for local anesthetics.Structural determinants of slow inactivation in human cardiac and skeletal muscle sodium channels.Rapid and slow voltage-dependent conformational changes in segment IVS6 of voltage-gated Na(+) channelsA model of the interaction between N-type and C-type inactivation in Kv1.4 channels.Sodium channel slow inactivation as a therapeutic target for myotonia congenitaA sodium channel pore mutation causing Brugada syndromeSubunit dependence of Na channel slow inactivation and open channel block in cerebellar neuronsGating transitions in the selectivity filter region of a sodium channel are coupled to the domain IV voltage sensor.Speeding the recovery from ultraslow inactivation of voltage-gated Na+ channels by metal ion binding to the selectivity filter: a foot-on-the-door?Sodium channel inactivation: molecular determinants and modulation.Use-dependent block of the voltage-gated Na(+) channel by tetrodotoxin and saxitoxin: effect of pore mutations that change ionic selectivity.Overexpressed Ca(v)beta3 inhibits N-type (Cav2.2) calcium channel currents through a hyperpolarizing shift of ultra-slow and closed-state inactivationA structural rearrangement in the sodium channel pore linked to slow inactivation and use dependence.mu-conotoxin GIIIA interactions with the voltage-gated Na(+) channel predict a clockwise arrangement of the domains.Role of domain 4 in sodium channel slow inactivationElectrostatic and steric contributions to block of the skeletal muscle sodium channel by mu-conotoxin.Molecular motions of the outer ring of charge of the sodium channel: do they couple to slow inactivation?Proton sensors in the pore domain of the cardiac voltage-gated sodium channel.Role of Ca(2+) in injury-induced changes in sodium current in rat skeletal muscleNovel molecular determinants in the pore region of sodium channels regulate local anesthetic binding.The outer vestibule of the Na+ channel-toxin receptor and modulator of permeation as well as gating.The role of slow and persistent TTX-resistant sodium currents in acute tumor necrosis factor-α-mediated increase in nociceptors excitability.The pore, not cytoplasmic domains, underlies inactivation in a prokaryotic sodium channel.Lidocaine induces a slow inactivated state in rat skeletal muscle sodium channels.Sodium channels: ionic model of slow inactivation and state-dependent drug binding.C-type inactivation involves a significant decrease in the intracellular aqueous pore volume of Kv1.4 K+ channels expressed in Xenopus oocytes.Kv1.4 channel block by quinidine: evidence for a drug-induced allosteric effect.The selectivity filter of the voltage-gated sodium channel is involved in channel activation.Role of outer ring carboxylates of the rat skeletal muscle sodium channel pore in proton block.Compound-specific Na+ channel pore conformational changes induced by local anaesthetics.A naturally occurring amino acid substitution in the voltage-dependent sodium channel selectivity filter affects channel gating.Marine Toxins That Target Voltage-gated Sodium Channels.Distinct modulation of inactivation by a residue in the pore domain of voltage-gated Na+ channels: mechanistic insights from recent crystal structures.Interaction between fast and ultra-slow inactivation in the voltage-gated sodium channel. Does the inactivation gate stabilize the channel structure?A conserved ring of charge in mammalian Na+ channels: a molecular regulator of the outer pore conformation during slow inactivation.
P2860
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P2860
Ultra-slow inactivation in mu1 Na+ channels is produced by a structural rearrangement of the outer vestibule
description
1999 nî lūn-bûn
@nan
1999 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի մարտին հրատարակված գիտական հոդված
@hy
1999年の論文
@ja
1999年学术文章
@wuu
1999年学术文章
@zh-cn
1999年学术文章
@zh-hans
1999年学术文章
@zh-my
1999年学术文章
@zh-sg
1999年學術文章
@yue
name
Ultra-slow inactivation in mu1 ...... ngement of the outer vestibule
@ast
Ultra-slow inactivation in mu1 ...... ngement of the outer vestibule
@en
type
label
Ultra-slow inactivation in mu1 ...... ngement of the outer vestibule
@ast
Ultra-slow inactivation in mu1 ...... ngement of the outer vestibule
@en
prefLabel
Ultra-slow inactivation in mu1 ...... ngement of the outer vestibule
@ast
Ultra-slow inactivation in mu1 ...... ngement of the outer vestibule
@en
P2093
P2860
P1433
P1476
Ultra-slow inactivation in mu1 ...... ngement of the outer vestibule
@en
P2093
P2860
P304
P356
10.1016/S0006-3495(99)77296-6
P407
P577
1999-03-01T00:00:00Z