Activation of the oncogenic potential of the avian cellular src protein by specific structural alteration of the carboxy terminus.
about
RACK1, a receptor for activated C kinase and a homolog of the beta subunit of G proteins, inhibits activity of src tyrosine kinases and growth of NIH 3T3 cellsCharacterization of ROS1 cDNA from a human glioblastoma cell lineMonoclonal antibodies to individual tyrosine-phosphorylated protein substrates of oncogene-encoded tyrosine kinases.Association of protein phosphatase 2A with polyoma virus medium tumor antigenReceptor protein tyrosine phosphatase alpha activates pp60c-src and is involved in neuronal differentiationMutational analysis of the Src SH3 domain: the same residues of the ligand binding surface are important for intra- and intermolecular interactionsTwo isoforms of murine hck, generated by utilization of alternative translational initiation codons, exhibit different patterns of subcellular localizationpp60c-src activation in human colon carcinomaGAB2--a scaffolding protein in cancerLck-dependent Fyn activation requires C terminus-dependent targeting of kinase-active Lck to lipid raftsComparative study of protein tyrosine phosphatase-epsilon isoforms: membrane localization confers specificity in cellular signallingRegulation of c-SRC activity and function by the adapter protein CASCsk suppression of Src involves movement of Csk to sites of Src activity.Stable association of pp60src and pp59fyn with the focal adhesion-associated protein tyrosine kinase, pp125FAK.Identification and sequence analysis of cDNAs encoding a 110-kilodalton actin filament-associated pp60src substrate.Binding of the Src SH2 domain to phosphopeptides is determined by residues in both the SH2 domain and the phosphopeptides.Suppression of c-Src activity by C-terminal Src kinase involves the c-Src SH2 and SH3 domains: analysis with Saccharomyces cerevisiae.En bloc substitution of the Src homology region 2 domain activates the transforming potential of the c-Abl protein tyrosine kinase.Effects of SH2 and SH3 deletions on the functional activities of wild-type and transforming variants of c-Src.Selective binding of activated pp60c-src by an immobilized synthetic phosphopeptide modeled on the carboxyl terminus of pp60c-srcIdentification and characterization of a novel cytoskeleton-associated pp60src substrate.The SH2 and SH3 domains of pp60src direct stable association with tyrosine phosphorylated proteins p130 and p110.Site-directed mutagenesis of the SH2- and SH3-coding domains of c-src produces varied phenotypes, including oncogenic activation of p60c-src.Glycoprotein tyrosine phosphorylation in Rous sarcoma virus-transformed chicken embryo fibroblasts.Tyrosine phosphorylation of a 120-kilodalton pp60src substrate upon epidermal growth factor and platelet-derived growth factor receptor stimulation and in polyomavirus middle-T-antigen-transformed cells.Transformation by pp60src or stimulation of cells with epidermal growth factor induces the stable association of tyrosine-phosphorylated cellular proteins with GTPase-activating protein.Adenovirus E4 open reading frame 4-induced apoptosis involves dysregulation of Src family kinases.Regulation of the oncogenic activity of the cellular src protein requires the correct spacing between the kinase domain and the C-terminal phosphorylated tyrosine (Tyr-527).Stable association of activated pp60src with two tyrosine-phosphorylated cellular proteinspp60c-src tyrosine kinase, myristylation, and modulatory domains are required for enhanced mitogenic responsiveness to epidermal growth factor seen in cells overexpressing c-srcTransformation-specific tyrosine phosphorylation of a novel cellular protein in chicken cells expressing oncogenic variants of the avian cellular src gene.Deletions and insertions within an amino-terminal domain of pp60v-src inactivate transformation and modulate membrane stabilityThe protooncogene c-sea encodes a transmembrane protein-tyrosine kinase related to the Met/hepatocyte growth factor/scatter factor receptorPotential positive and negative autoregulation of p60c-src by intermolecular autophosphorylation.Mutation of a site of tyrosine phosphorylation in the lymphocyte-specific tyrosine protein kinase, p56lck, reveals its oncogenic potential in fibroblasts.A retroviral promoter is sufficient to convert proto-src to a transforming gene that is distinct from the src gene of Rous sarcoma virus.v-Src enhances phosphorylation at Ser-282 of the Rous sarcoma virus integraseFunctional analysis and nucleotide sequence of the promoter region of the murine hck gene.RACK1 regulates G1/S progression by suppressing Src kinase activity.Conformational processing of oncogenic v-Src kinase by the molecular chaperone Hsp90.
P2860
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P2860
Activation of the oncogenic potential of the avian cellular src protein by specific structural alteration of the carboxy terminus.
description
1987 nî lūn-bûn
@nan
1987 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
1987 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
1987年の論文
@ja
1987年学术文章
@wuu
1987年学术文章
@zh-cn
1987年学术文章
@zh-hans
1987年学术文章
@zh-my
1987年学术文章
@zh-sg
1987年學術文章
@yue
name
Activation of the oncogenic po ...... ation of the carboxy terminus.
@ast
Activation of the oncogenic po ...... ation of the carboxy terminus.
@en
type
label
Activation of the oncogenic po ...... ation of the carboxy terminus.
@ast
Activation of the oncogenic po ...... ation of the carboxy terminus.
@en
prefLabel
Activation of the oncogenic po ...... ation of the carboxy terminus.
@ast
Activation of the oncogenic po ...... ation of the carboxy terminus.
@en
P2093
P2860
P1433
P1476
Activation of the oncogenic po ...... ration of the carboxy terminus
@en
P2093
P2860
P304
P356
10.1002/J.1460-2075.1987.TB02512.X
P407
P577
1987-08-01T00:00:00Z