Rous sarcoma virus variants that encode src proteins with an altered carboxy terminus are defective for cellular transformation.
about
Mutagenesis of avian carcinoma virus MH2: only one of two potential transforming genes (delta gag-myc) transforms fibroblastsRegulation of the oncogenic activity of the cellular src protein requires the correct spacing between the kinase domain and the C-terminal phosphorylated tyrosine (Tyr-527).Activation of the oncogenic potential of the avian cellular src protein by specific structural alteration of the carboxy terminus.A Swiss 3T3 variant cell line resistant to the effects of tumor promoters cannot be transformed by srcTransformation-specific tyrosine phosphorylation of a novel cellular protein in chicken cells expressing oncogenic variants of the avian cellular src gene.Deletions and insertions within an amino-terminal domain of pp60v-src inactivate transformation and modulate membrane stabilityInhibition of the tyrosine kinase activity of v-src, v-fgr, and v-yes gene products by a monoclonal antibody which binds both amino and carboxy peptide fragments of pp60v-src.Site-directed mutagenesis of the gag-myc gene of avian myelocytomatosis virus 29: biological activity and intracellular localization of structurally altered proteins.Molecular cloning and characterization of the RNA packaging-defective retrovirus SE21Q1bA lysine in the ATP-binding site of P130gag-fps is essential for protein-tyrosine kinase activity.A retroviral promoter is sufficient to convert proto-src to a transforming gene that is distinct from the src gene of Rous sarcoma virus.v-Src enhances phosphorylation at Ser-282 of the Rous sarcoma virus integraseAvian proto-myc genes promoted by defective or nondefective retroviruses are single-hit transforming genes in primary cells.The packaging phenotype of the SE21Q1b provirus is related to high proviral expression and not trans-acting factors.Ontogeny of the v-erbA oncoprotein from the thyroid hormone receptor: an alteration in the DNA binding domain plays a role crucial for v-erbA functionSpecificity of retroviral RNA packaging.Structural differences between repressed and derepressed forms of p60c-srcv-src mutations outside the carboxyl-coding region are not sufficient to fully activate transformation by pp60c-src in NIH 3T3 cells.DNA sequence encoding the amino-terminal region of the human c-src protein: implications of sequence divergence among src-type kinase oncogenes.Expression of a molecularly cloned human c-src oncogene by using a replication-competent retroviral vectorFeatures of the pp60v-src carboxyl terminus that are required for transformation.Unmutated proto-src coding region is tumorigenic if expressed from the promoter of Rous sarcoma virus: implications for the gene-mutation hypothesis of cancer.Intracellular localization and processing of pp60v-src proteins expressed by two distinct temperature-sensitive mutants of Rous sarcoma virus.Altered sites of tyrosine phosphorylation in pp60c-src associated with polyomavirus middle tumor antigen.
P2860
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P2860
Rous sarcoma virus variants that encode src proteins with an altered carboxy terminus are defective for cellular transformation.
description
1985 nî lūn-bûn
@nan
1985 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
1985 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
1985年の論文
@ja
1985年論文
@yue
1985年論文
@zh-hant
1985年論文
@zh-hk
1985年論文
@zh-mo
1985年論文
@zh-tw
1985年论文
@wuu
name
Rous sarcoma virus variants th ...... e for cellular transformation.
@ast
Rous sarcoma virus variants th ...... e for cellular transformation.
@en
type
label
Rous sarcoma virus variants th ...... e for cellular transformation.
@ast
Rous sarcoma virus variants th ...... e for cellular transformation.
@en
prefLabel
Rous sarcoma virus variants th ...... e for cellular transformation.
@ast
Rous sarcoma virus variants th ...... e for cellular transformation.
@en
P2093
P2860
P1433
P1476
Rous sarcoma virus variants th ...... e for cellular transformation.
@en
P2093
D L Bryant
J T Parsons
V W Wilkerson
P2860
P304
P577
1985-08-01T00:00:00Z