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Mechanisms of CAS substrate domain tyrosine phosphorylation by FAK and Src

Mechanisms of CAS substrate domain tyrosine phosphorylation by FAK and Src

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NEDD9 stabilizes focal adhesions, increases binding to the extra-cellular matrix and differentially effects 2D versus 3D cell migration P130Cas-associated protein (p140Cap) as a new tyrosine-phosphorylated protein involved in cell spreading Ack1 mediates Cdc42-dependent cell migration and signaling to p130Cas Pseudopodium-enriched atypical kinase 1 regulates the cytoskeleton and cancer progression [corrected].Pyk2 mediates endothelin-1 signaling via p130Cas/BCAR3 cascade and regulates human glomerular mesangial cell adhesion and spreading R-Ras promotes focal adhesion formation through focal adhesion kinase and p130(Cas) by a novel mechanism that differs from integrins.A p130Cas tyrosine phosphorylated substrate domain decoy disrupts v-crk signaling Caspase-8 as a regulator of tumor cell motility P130Cas Src-binding and substrate domains have distinct roles in sustaining focal adhesion disassembly and promoting cell migration In vivo epidermal migration requires focal adhesion targeting of ACF7 Molecular basis for HEF1/NEDD9/Cas-L action as a multifunctional co-ordinator of invasion, apoptosis and cell cycle Cas and NEDD9 Contribute to Tumor Progression through Dynamic Regulation of the Cytoskeleton.NSP-CAS Protein Complexes: Emerging Signaling Modules in Cancer Regulation of invasive behavior by vascular endothelial growth factor is HEF1-dependent Loss of AND-34/BCAR3 expression in mice results in rupture of the adult lens FAK deficiency in cells contributing to the basal lamina results in cortical abnormalities resembling congenital muscular dystrophies Abl silencing inhibits CAS-mediated process and constriction in resistance arteries Conditional knockout of focal adhesion kinase in endothelial cells reveals its role in angiogenesis and vascular development in late embryogenesis Breast cancer anti-estrogen resistance 3 (BCAR3) protein augments binding of the c-Src SH3 domain to Crk-associated substrate (p130cas)Tyrosine phosphorylation within the SH3 domain regulates CAS subcellular localization, cell migration, and invasiveness The SH2 domain protein Shep1 regulates the in vivo signaling function of the scaffolding protein Cas Dynamics and mechanism of p130Cas localization to focal adhesions Requirement of Nck adaptors for actin dynamics and cell migration stimulated by platelet-derived growth factor B.Src and FAK kinases cooperate to phosphorylate paxillin kinase linker, stimulate its focal adhesion localization, and regulate cell spreading and protrusiveness.Synergistic promotion of c-Src activation and cell migration by Cas and AND-34/BCAR3.N-WASP-directed actin polymerization activates Cas phosphorylation and lamellipodium spreading.A FAK-Cas-Rac-lamellipodin signaling module transduces extracellular matrix stiffness into mechanosensitive cell cycling.Paxillin-Y118 phosphorylation contributes to the control of Src-induced anchorage-independent growth by FAK and adhesion.Focal adhesion kinase as a regulator of cell tension in the progression of cancer.Phosphorylation of p130Cas initiates Rac activation and membrane ruffling.Invasion of host cells by Salmonella typhimurium requires focal adhesion kinase and p130Cas Src phosphorylates Cas on tyrosine 253 to promote migration of transformed cells FAK potentiates Rac1 activation and localization to matrix adhesion sites: a role for betaPIX.Integrin-mediated mechanotransduction pathway of low-intensity continuous ultrasound in human chondrocytes Cortactin tyrosine phosphorylation requires Rac1 activity and association with the cortical actin cytoskeleton.A FAK/Src chimera with gain-of-function properties promotes formation of large peripheral adhesions associated with dynamic actin assembly.p130Cas scaffolds the signalosome to direct adaptor-effector cross talk during Kaposi's sarcoma-associated herpesvirus trafficking in human microvascular dermal endothelial cells A Kinase-Independent Function of c-Src Mediates p130Cas Phosphorylation at the Serine-639 Site in Pressure Overloaded Myocardium.Synthesis of functional signaling domains by combinatorial polymerization of phosphorylation motifs.Tropomyosin isoform modulation of focal adhesion structure and cell migration.

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Mechanisms of CAS substrate domain tyrosine phosphorylation by FAK and Src

http://www.wikidata.org/entity/Q30453539

description

2001 nî lūn-bûn

@nan

2001 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած

@hyw

2001 թվականի նոյեմբերին հրատարակված գիտական հոդված

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2001年の論文

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2001年論文

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2001年論文

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2001年論文

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2001年論文

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2001年論文

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2001年论文

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name

Mechanisms of CAS substrate domain tyrosine phosphorylation by FAK and Src

@ast

Mechanisms of CAS substrate domain tyrosine phosphorylation by FAK and Src

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type

label

Mechanisms of CAS substrate domain tyrosine phosphorylation by FAK and Src

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Mechanisms of CAS substrate domain tyrosine phosphorylation by FAK and Src

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prefLabel

Mechanisms of CAS substrate domain tyrosine phosphorylation by FAK and Src

@ast

Mechanisms of CAS substrate domain tyrosine phosphorylation by FAK and Src

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MCB.21.22.7641-7652.2001

P1433

Molecular and Cellular Biology

P1476

Mechanisms of CAS substrate domain tyrosine phosphorylation by FAK and Src

@en

P2093

N Y Shin

http://www.w3.org/2001/XMLSchema#string

P J Ruest

http://www.w3.org/2001/XMLSchema#string

S K Hanks

http://www.w3.org/2001/XMLSchema#string

T R Polte

http://www.w3.org/2001/XMLSchema#string

X Zhang

http://www.w3.org/2001/XMLSchema#string

P2860

Activation of Rac1 by a Crk SH3-binding protein, DOCK180

BCAR1, a human homologue of the adapter protein p130Cas, and antiestrogen resistance in breast cancer cells

Integrin signalling: a new Cas(t) of characters enters the stage

SH2-containing inositol 5'-phosphatase SHIP2 associates with the p130(Cas) adapter protein and regulates cellular adhesion and spreading

C3G, a guanine nucleotide-releasing protein expressed ubiquitously, binds to the Src homology 3 domains of CRK and GRB2/ASH proteins

Tyrosine phosphorylation of focal adhesion kinase at sites in the catalytic domain regulates kinase activity: a role for Src family kinases

Association of PTP-PEST with the SH3 domain of p130cas; a novel mechanism of protein tyrosine phosphatase substrate recognition

CAS/Crk coupling serves as a "molecular switch" for induction of cell migration.

Introduction of p130cas signaling complex formation upon integrin-mediated cell adhesion: a role for Src family kinases

Transformation suppression by protein tyrosine phosphatase 1B requires a functional SH3 ligand

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7641-7652

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10.1128/MCB.21.22.7641-7652.2001

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11745041

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11604500

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phosphorylation

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99935

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