SH2-containing inositol 5'-phosphatase SHIP2 associates with the p130(Cas) adapter protein and regulates cellular adhesion and spreading
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LL5beta directs the translocation of filamin A and SHIP2 to sites of phosphatidylinositol 3,4,5-triphosphate (PtdIns(3,4,5)P3) accumulation, and PtdIns(3,4,5)P3 localization is mutually modified by co-recruited SHIP2.Silencer of death domains (SODD) inhibits skeletal muscle and kidney enriched inositol 5-phosphatase (SKIP) and regulates phosphoinositide 3-kinase (PI3K)/Akt signaling to the actin cytoskeletonThe SH2-containing inositol polyphosphate 5-phosphatase, SHIP-2, binds filamin and regulates submembraneous actinThe Src homology 2 domain containing inositol 5-phosphatase SHIP2 is recruited to the epidermal growth factor (EGF) receptor and dephosphorylates phosphatidylinositol 3,4,5-trisphosphate in EGF-stimulated COS-7 cellsTks5 and SHIP2 regulate invadopodium maturation, but not initiation, in breast carcinoma cellsDifferential regulation of cell migration, actin stress fiber organization, and cell transformation by functional domains of Crk-associated substrateAn essential role for the SHIP2-dependent negative feedback loop in neuritogenesis of nerve growth factor-stimulated PC12 cellsp130Cas, Crk-associated substrate plays essential roles in liver development by regulating sinusoidal endothelial cell fenestrationSHIP2 multiple functions: a balance between a negative control of PtdIns(3,4,5)P₃ level, a positive control of PtdIns(3,4)P₂ production, and intrinsic docking properties.Mechanisms of CAS substrate domain tyrosine phosphorylation by FAK and SrcNetwork analysis of the focal adhesion to invadopodia transition identifies a PI3K-PKCα invasive signaling axis5'-Inositol phosphatase SHIP2 recruits Mena to stabilize invadopodia for cancer cell invasion.LyGDI, a novel SHIP-interacting protein, is a negative regulator of FcγR-mediated phagocytosis.The inositol 5-phosphatase SHIP2 regulates endocytic clathrin-coated pit dynamicsNephrin regulates lamellipodia formation by assembling a protein complex that includes Ship2, filamin and lamellipodinThe host phosphoinositide 5-phosphatase SHIP2 regulates dissemination of vaccinia virusJAM-A regulates cortical dynein localization through Cdc42 to control planar spindle orientation during mitosis.Potential molecular mechanism for c-Src kinase-mediated regulation of intestinal cell migration.SHIP2 regulates epithelial cell polarity through its lipid product, which binds to Dlg1, a pathway subverted by hepatitis C virus core proteinElevated expression of SHIP2 correlates with poor prognosis in non-small cell lung cancer.SHIP2 (SH2 domain-containing inositol phosphatase 2) SH2 domain negatively controls SHIP2 monoubiquitination in response to epidermal growth factor.Lipid phosphatase SHIP2 functions as oncogene in colorectal cancer by regulating PKB activation.SHIP2 and its involvement in various diseases.Stretchy proteins on stretchy substrates: the important elements of integrin-mediated rigidity sensing.Mechanoregulation of stem cell fate via micro-/nano-scale manipulation for regenerative medicine.Inositol lipid phosphatases in membrane trafficking and human disease.SHIP2: Structure, Function and Inhibition.How does SHIP1/2 balance PtdIns(3,4)P2 and does it signal independently of its phosphatase activity?Molecular characterization, expression pattern, and association analysis with carcass traits of the porcine SHIP2 gene.TGF-beta1 (transforming growth factor-beta1)-mediated adhesion of gastric carcinoma cells involves a decrease in Ras/ERKs (extracellular-signal-regulated kinases) cascade activity dependent on c-Src activity.Integrin-induced epidermal growth factor (EGF) receptor activation requires c-Src and p130Cas and leads to phosphorylation of specific EGF receptor tyrosines.SH2-containing inositol 5-phosphatases 1 and 2 in blood platelets: their interactions and roles in the control of phosphatidylinositol 3,4,5-trisphosphate levels.Pharmacological targeting of phosphoinositide lipid kinases and phosphatases in the immune system: success, disappointment, and new opportunities.PTEN, but not SHIP and SHIP2, suppresses the PI3K/Akt pathway and induces growth inhibition and apoptosis of myeloma cells.Phosphoproteomic analysis identifies insulin enhancement of discoidin domain receptor 2 phosphorylation.Expression and Production of SH2 Domain Proteins.Suppression of SHIP2 contributes to tumorigenesis and proliferation of gastric cancer cells via activation of Akt.
P2860
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P2860
SH2-containing inositol 5'-phosphatase SHIP2 associates with the p130(Cas) adapter protein and regulates cellular adhesion and spreading
description
2001 nî lūn-bûn
@nan
2001 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
name
SH2-containing inositol 5'-pho ...... ellular adhesion and spreading
@ast
SH2-containing inositol 5'-pho ...... ellular adhesion and spreading
@en
SH2-containing inositol 5'-pho ...... ellular adhesion and spreading
@en-gb
SH2-containing inositol 5'-pho ...... ellular adhesion and spreading
@nl
type
label
SH2-containing inositol 5'-pho ...... ellular adhesion and spreading
@ast
SH2-containing inositol 5'-pho ...... ellular adhesion and spreading
@en
SH2-containing inositol 5'-pho ...... ellular adhesion and spreading
@en-gb
SH2-containing inositol 5'-pho ...... ellular adhesion and spreading
@nl
prefLabel
SH2-containing inositol 5'-pho ...... ellular adhesion and spreading
@ast
SH2-containing inositol 5'-pho ...... ellular adhesion and spreading
@en
SH2-containing inositol 5'-pho ...... ellular adhesion and spreading
@en-gb
SH2-containing inositol 5'-pho ...... ellular adhesion and spreading
@nl
P2093
P2860
P1476
SH2-containing inositol 5'-pho ...... ellular adhesion and spreading
@en
P2093
P2860
P304
P356
10.1128/MCB.21.4.1416-1428.2001
P407
P577
2001-02-01T00:00:00Z