A novel leptin signalling pathway via PTEN inhibition in hypothalamic cell lines and pancreatic beta-cells. - Wikidata - wikimedia - TriplyDB

A novel leptin signalling pathway via PTEN inhibition in hypothalamic cell lines and pancreatic beta-cells.

A novel leptin signalling pathway via PTEN inhibition in hypothalamic cell lines and pancreatic beta-cells.

http://www.wikidata.org/entity/Q30477420

about

A phosphorylation-dependent intramolecular interaction regulates the membrane association and activity of the tumor suppressor PTEN.Leptin regulates AMPA receptor trafficking via PTEN inhibition Hormone and glucose signalling in POMC and AgRP neurons.PTEN depletion decreases disease severity and modestly prolongs survival in a mouse model of spinal muscular atrophy.Melatonin and Fertoprotective Adjuvants: Prevention against Premature Ovarian Failure during Chemotherapy.Loss of AMP-activated protein kinase alpha2 subunit in mouse beta-cells impairs glucose-stimulated insulin secretion and inhibits their sensitivity to hypoglycaemia.Functional analysis of the protein phosphatase activity of PTEN Sex differences in skeletal muscle phosphatase and tensin homolog deleted on chromosome 10 (PTEN) levels: a cross-sectional study.Leptin Elongates Hypothalamic Neuronal Cilia via Transcriptional Regulation and Actin Destabilization Enhanced GLP-1- and sulfonylurea-induced insulin secretion in islets lacking leptin signaling.Disruption of leptin receptor expression in the pancreas directly affects beta cell growth and function in mice.A dangerous liaison: Leptin and sPLA2-IIA join forces to induce proliferation and migration of astrocytoma cells Rac-mediated actin remodeling and myosin II are involved in KATP channel trafficking in pancreatic β-cells.Concerted Trafficking Regulation of Kv2.1 and KATP Channels by Leptin in Pancreatic β-Cells.Leptin Suppresses Mouse Taste Cell Responses to Sweet Compounds.Leptin regulation of neuronal excitability and cognitive function Voluntary exercise prevents the obese and diabetic metabolic syndrome of the melanocortin-4 receptor knockout mouse.Leptin-mediated ion channel regulation: PI3K pathways, physiological role, and therapeutic potential Inhibitory effects of leptin on pancreatic alpha-cell function.Growth factor control of pancreatic islet regeneration and function Leptin regulates KATP channel trafficking in pancreatic β-cells by a signaling mechanism involving AMP-activated protein kinase (AMPK) and cAMP-dependent protein kinase (PKA).PTEN regulates AMPA receptor-mediated cell viability in iPS-derived motor neurons.Loss of NDRG2 expression activates PI3K-AKT signalling via PTEN phosphorylation in ATLL and other cancers.Leptin regulation of neuronal morphology and hippocampal synaptic function Leptin-stimulated KATP channel trafficking: a new paradigm for β-cell stimulus-secretion coupling?PTEN function: the long and the short of it.Synergistic effect of melatonin and ghrelin in preventing cisplatin-induced ovarian damage via regulation of FOXO3a phosphorylation and binding to the p27Kip1 promoter in primordial follicles.Maintenance of redox state and pancreatic beta-cell function: role of leptin and adiponectin.Suppression of cellular proliferation and invasion by the concerted lipid and protein phosphatase activities of PTEN.Leptin-dependent phosphorylation of PTEN mediates actin restructuring and activation of ATP-sensitive K+ channels PTEN is destabilized by phosphorylation on Thr366.Leptin: a novel therapeutic target in Alzheimer's disease?Obesity and the beta cell: lessons from leptin.PTEN in liver diseases and cancer Regulation of PTEN activity by its carboxyl-terminal autoinhibitory domain.Dominant role of the p110beta isoform of PI3K over p110alpha in energy homeostasis regulation by POMC and AgRP neurons.Early lesion formation in colorectal carcinogenesis is associated with adiponectin status whereas neoplastic lesions are associated with diet and sex in C57BL/6J mice.PTEN Physically Interacts with and Regulates E2F1-mediated Transcription in Lung Cancer.Melatonin prevents cisplatin-induced primordial follicle loss via suppression of PTEN/AKT/FOXO3a pathway activation in the mouse ovary.Mediobasal hypothalamic PTEN modulates hepatic insulin resistance independently of food intake in rats.

P2860

Q28305284-9546DC72-F565-49BB-9EC4-71678725C8D9 Q28579654-6D41A83D-9E5D-41C5-B5C1-779DE0CCC402 Q30380963-CE75764B-5AA6-4383-879C-713A48B5562A Q30651854-0F882C93-96E7-4599-80B1-1E14A8675FE8 Q33838766-E91207B3-E388-4D44-8161-C58747B4DFCC Q34115152-E7EE9475-29AC-4B19-802E-657FE38064F5 Q34194118-108E16A7-60B5-4C00-A4B2-B9594C58B2B1 Q35195513-AB305415-A2D2-4E0B-BBFD-B1DA517B5982 Q35859561-B9145EE2-23F1-495B-BA4D-2BCB2CBFF806 Q35970054-D26CE3E4-1858-4AA1-B570-E09BE2115289 Q36014510-61587484-40F0-49F3-AB5F-B80D5B98683C Q36294159-2E863486-70B4-4D64-82DB-3F6D7366684A Q36356970-78BE8BF5-766F-4CEF-8C81-F20ACB44B915 Q36444181-A347BC12-E24E-4D9C-B3F7-54F692E9D384 Q36926227-1293AC44-6120-405E-9C6E-F07EE39427AC Q37007039-B1C794C2-617F-4887-8379-48B71BD0EB65 Q37072395-75E39162-20B8-4E28-9A44-21B79CADE818 Q37112040-74F0AAF8-D35C-4EC1-8B39-15906A3BFFF9 Q37236295-FA5A247C-4043-44EB-A362-8954CD75130F Q37283982-8FF955E8-A203-450A-B82B-984FBEF404E7 Q37333827-2EDA5153-FDD2-4C7A-9FE4-04310A09C6A3 Q37620711-888E4F86-1C1E-47B8-9F4C-F5D15F9D9C71 Q37627634-C36EBA47-2118-4187-A0B1-2A5A1469ABFC Q38130497-E51D9BCE-94BE-4BE4-B138-C4E2F17685A9 Q38161388-8DEAE01A-5152-4932-A614-7565F37BE270 Q38198345-932D0E81-6E63-4244-B048-3276DD406AAB Q38401545-436D49B9-010A-4D9B-BB36-9704A092D4E3 Q39410765-45AC173A-7F65-479E-A77D-3BD058E6BD23 Q39774233-305251D5-E72D-4454-8FBA-34E28A534849 Q39885152-F122A8E1-BC51-4BAA-9B47-FC9F984EBF46 Q40143795-80D6C349-8FD5-4FAB-B606-DAFFE8BD731A Q40292339-F0A2E554-D364-4B5F-B475-8C085C3EEDB9 Q41376166-2E211B63-545E-48C8-BF62-D585DA38E57C Q42412809-3DEE5975-EBE1-473F-8850-C2A25798BFFE Q42827470-2DE3B53D-A359-4BBF-9036-CA80246DEA81 Q42937219-641A043F-D178-49DF-BD78-B0E3C82AD4D6 Q44331224-2A6BEA7B-D91D-4960-AD1A-D2F83CEFE860 Q47435142-3B10499D-9F40-469F-9E11-5BB9DEA99D50 Q48237352-AB5E5D38-25C2-4A56-BA52-43B2FE9926BD Q54352981-666DBEC2-BAE1-42DB-A362-D8201CB9D6CD

P2860

A novel leptin signalling pathway via PTEN inhibition in hypothalamic cell lines and pancreatic beta-cells.

http://www.wikidata.org/entity/Q30477420

description

2006 nî lūn-bûn

@nan

2006 թուականի Մայիսին հրատարակուած գիտական յօդուած

@hyw

2006 թվականի մայիսին հրատարակված գիտական հոդված

@hy

2006年の論文

@ja

2006年論文

@yue

2006年論文

@zh-hant

2006年論文

@zh-hk

2006年論文

@zh-mo

2006年論文

@zh-tw

2006年论文

@wuu

name

A novel leptin signalling path ...... nes and pancreatic beta-cells.

@ast

A novel leptin signalling path ...... nes and pancreatic beta-cells.

@en

type

label

A novel leptin signalling path ...... nes and pancreatic beta-cells.

@ast

A novel leptin signalling path ...... nes and pancreatic beta-cells.

@en

prefLabel

A novel leptin signalling path ...... nes and pancreatic beta-cells.

@ast

A novel leptin signalling path ...... nes and pancreatic beta-cells.

@en

P1433

Q30477420-1718001F-3AD6-4A9E-A8CF-435C68A1E269

P1476

Q30477420-4E8EB37D-46A8-4617-A19A-C477B144ACEC

P2093

Q30477420-03EF4314-536C-45C7-B45C-FB2FDE4DA40A

Q30477420-17D8E9D8-FF84-428E-AACD-B74A552AA1C7

Q30477420-61DC139F-A63E-4E7D-8987-23475C175210

Q30477420-8BEFE68A-DA91-4D18-9F03-EC031FD20515

Q30477420-8E471635-F1AD-4416-9DFD-DD82EAB12F39

Q30477420-D7760A48-4679-4CE0-807C-29348131ED8B

Q30477420-EAF77B6B-9379-4948-96B5-9947298A66D8

Q30477420-EF88C1CA-884D-4D48-BA7F-7E1B1DB5F525

P2860

Q30477420-00F94137-43EC-48E8-BB23-92D5821878F1

Q30477420-0DEB1AF1-F018-461B-A4A8-47EFD57FBE76

Q30477420-1F067F71-66A0-4970-9B4E-0A12C0AD2D17

Q30477420-20FA60CD-77A6-4EB5-8EEA-896615ABE9D9

Q30477420-22EFA0E7-285B-47A3-AC9C-475A45865425

Q30477420-3D4EAC61-C1BC-439E-A18F-229452807093

Q30477420-4232261E-CE28-49EF-9E61-888DB22B86F1

Q30477420-4F46373C-0F15-4A5F-A515-4ED9FE0B9CE6

Q30477420-56725F26-D69D-4451-BC5E-ACCA9C8AADF1

Q30477420-5BF9619D-75EA-4F7A-9E78-301247337BBA

P304

Q30477420-3BEDB060-4D37-4D74-9795-BE25CD1D618D

P31

Q30477420-6F4DF64D-EB95-4CEB-963B-93D2323B1EB0

P356

Q30477420-3EE36D09-CB9F-40FE-9079-DCD76E778B6B

P407

Q30477420-9592FB98-4A10-4F36-99BF-1310812A2D0F

P433

Q30477420-88675F0D-80F5-48A1-8F60-4E6482A88C7A

P478

Q30477420-A7AE4F0D-8A08-4897-B0B9-6BCE6BAC981B

P577

Q30477420-8920F70F-22E8-4A5D-B9A2-A3F637C0730F

P5875

Q30477420-1248C47B-C94D-4925-AAD9-0FAB6E34EB5B

P698

Q30477420-35570AB1-56DB-49C1-8459-B918C7600BA2

P932

Q30477420-63184B0B-AC92-4B4E-81F0-3748010F7988

P356

SJ.EMBOJ.7601118

P1433

The EMBO Journal

P1476

A novel leptin signalling path ...... nes and pancreatic beta-cells.

@en

P2093

C Peter Downes

http://www.w3.org/2001/XMLSchema#string

Hilary A Laidlaw

http://www.w3.org/2001/XMLSchema#string

Ke Ning

http://www.w3.org/2001/XMLSchema#string

Laura A Burgess

http://www.w3.org/2001/XMLSchema#string

Lisa C Miller

http://www.w3.org/2001/XMLSchema#string

Michael L J Ashford

http://www.w3.org/2001/XMLSchema#string

Nevin M Perera

http://www.w3.org/2001/XMLSchema#string

Nick R Leslie

http://www.w3.org/2001/XMLSchema#string

P2860

The lipid phosphatase activity of PTEN is critical for its tumor supressor function

The tumor suppressor PTEN is phosphorylated by the protein kinase CK2 at its C terminus. Implications for PTEN stability to proteasome-mediated degradation

Inhibition of cell migration, spreading, and focal adhesions by tumor suppressor PTEN

PTEN function: how normal cells control it and tumour cells lose it

Leptin and insulin stimulation of signalling pathways in arcuate nucleus neurones: PI3K dependent actin reorganization and KATP channel activation

Direct identification of PTEN phosphorylation sites

Targeting mutants of PTEN reveal distinct subsets of tumour suppressor functions

Intracellular signalling. Key enzyme in leptin-induced anorexia

A phosphatidylinositol 3-kinase phosphodiesterase 3B-cyclic AMP pathway in hypothalamic action of leptin on feeding

Central nervous system control of food intake

P304

2377-2387

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1038/SJ.EMBOJ.7601118

http://www.w3.org/2001/XMLSchema#string

P407

P433

11

http://www.w3.org/2001/XMLSchema#string

P478

25

http://www.w3.org/2001/XMLSchema#string

P577

2006-05-04T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

7104974

http://www.w3.org/2001/XMLSchema#string

P698

16675953

http://www.w3.org/2001/XMLSchema#string

P932

1478173

http://www.w3.org/2001/XMLSchema#string