Role of the copper transporter, CTR1, in platinum-induced ototoxicity. - Wikidata - wikimedia - TriplyDB

Role of the copper transporter, CTR1, in platinum-induced ototoxicity.

Role of the copper transporter, CTR1, in platinum-induced ototoxicity.

http://www.wikidata.org/entity/Q30477867

about

Platinum-induced ototoxicity in children: a consensus review on mechanisms, predisposition, and protection, including a new International Society of Pediatric Oncology Boston ototoxicity scale.Systems biology of cisplatin resistance: past, present and future Nanoscale drug delivery platforms overcome platinum-based resistance in cancer cells due to abnormal membrane protein trafficking Human OCT2 variant c.808G>T confers protection effect against cisplatin-induced ototoxicity.An integrated view of cisplatin-induced nephrotoxicity and ototoxicity Downstream targets of Lmo4 are modulated by cisplatin in the inner ear of Wistar rats Immunohistochemical localization of OCT2 in the cochlea of various species.Sensory hair cell death and regeneration in fishes The zebrafish merovingian mutant reveals a role for pH regulation in hair cell toxicity and function.Membrane transporters as mediators of Cisplatin effects and side effects.Cisplatin and aminoglycoside antibiotics: hearing loss and its prevention.Sound preconditioning therapy inhibits ototoxic hearing loss in mice.The design and screening of drugs to prevent acquired sensorineural hearing loss Copper transporter CTR1 expression and tissue platinum concentration in non-small cell lung cancer.In vitro and in vivo models of drug ototoxicity: studying the mechanisms of a clinical problem.DNA repair mechanisms in cancer development and therapy Cisplatin ototoxicity in rat cochlear organotypic cultures.Molecular architecture of the stria vascularis membrane transport system, which is essential for physiological functions of the mammalian cochlea.Contribution of tumoral and host solute carriers to clinical drug response.Pseudo-immortalization of postnatal cochlear progenitor cells yields a scalable cell line capable of transcriptionally regulating mature hair cell genes.Functional mechanotransduction is required for cisplatin-induced hair cell death in the zebrafish lateral line.A Comprehensive Review on the Genetic Regulation of Cisplatin-induced Nephrotoxicity Polymorphic transporters and platinum pharmacodynamics MiR-182-5p protects inner ear hair cells from cisplatin-induced apoptosis by inhibiting FOXO3a Targeting nitrative stress for attenuating cisplatin-induced downregulation of cochlear LIM domain only 4 and ototoxicity The role of inherited TPMT and COMT genetic variation in cisplatin-induced ototoxicity in children with cancer.Uptake carriers and oncology drug safety.Review: ototoxic characteristics of platinum antitumor drugs.Cisplatin-induced apoptosis in auditory, renal, and neuronal cells is associated with nitration and downregulation of LMO4.Pharmacotherapeutic options for treating adverse effects of Cisplatin chemotherapy.The Role of Transporters in the Toxicity of Chemotherapeutic Drugs: Focus on Transporters for Organic Cations.Hydrogen Inhalation Protects against Ototoxicity Induced by Intravenous Cisplatin in the Guinea Pig.The effect of sodium thiosulfate on the metabolism of cis-platin in human plasma in vitro.The effects of silver ions on copper metabolism in rats.Mechanisms of Cisplatin-Induced Ototoxicity and Otoprotection.Fortification of blood plasma from cancer patients with human serum albumin decreases the concentration of cisplatin-derived toxic hydrolysis products in vitro.Inhibition of Mitochondrial Division Attenuates Cisplatin-Induced Toxicity in the Neuromast Hair Cells.Theaflavin-3,3'-Digallate Enhances the Inhibitory Effect of Cisplatin by Regulating the Copper Transporter 1 and Glutathione in Human Ovarian Cancer Cells.CRISPR/Cas9-mediated knockout of Lim-domain only four retards organ of Corti cell growth.Overcoming cisplatin resistance in non-small cell lung cancer with Mad2 silencing siRNA delivered systemically using EGFR-targeted chitosan nanoparticles.

P2860

Q24615296-6FD0DA40-ED8D-41A8-BE49-FFE9345AAD3D Q26863585-393A6996-ADF8-4875-A170-C50BDF462C07 Q27011482-A62E87DF-4ECC-4E9F-A60D-969456757945 Q27335267-CE446448-B0E7-4DBE-9582-ABCC9CEC741E Q28080615-5CEF880E-C5A9-46D6-B4A2-56A7A592944F Q28542704-077D662F-CE57-47D0-BF37-414E5A291ADA Q30368484-2F358F5C-46B5-4664-B363-A84946DC6B25 Q30412456-95EA49B8-26FF-4D92-83DC-AB7E73A60FA6 Q30434681-979540BB-DC59-40DD-ADDE-4F5ED5AC8D53 Q30446860-3D52405A-D31D-47B7-AF55-8ACA9C6C4F2C Q30447637-7A2813E1-2BAC-4113-A1B8-8B0E58461239 Q30447926-A6191B69-B847-4C42-B4D5-199005B69D70 Q30465748-AFD0876D-370B-472A-8486-F42E1ED89B39 Q33875938-8A713096-C1D8-488B-82FD-41643D9DE0D5 Q34224262-A014CE75-5F41-438E-8E44-465C5102D8DC Q35531287-8CB659B4-3EFD-4E57-936E-D921933C18DD Q35592843-A37A4F11-9A20-466D-9FF5-E70231298200 Q35659340-7977DCBD-6A05-4654-A1A6-381EA51C5B9B Q35946876-2C7A974C-8ADE-4C53-B8A4-EAF2FE4A4955 Q36350118-0D8A560D-7D0D-4BEA-9359-CCE92159E27D Q36883651-001D9B68-6B79-4815-B031-E5590844DDC2 Q36906569-1C2EFBFD-9C08-4EAC-B244-412CC0F42F32 Q36995742-1D09BDCF-5FD5-420B-9C22-9463C605275E Q37330806-1A556EAA-5FCE-4DB3-9187-8DD0F6453F88 Q37399079-7ED1DC8A-C175-47AD-ACAF-63971712F5E7 Q37444522-A24FF55B-1A26-4240-BC3F-F7F693BDE3CA Q37663396-F2A47FE6-9471-4A24-9D1F-9713F0497BAC Q38050374-EF2E7325-F146-4968-8210-03416C146E07 Q38617889-9DB85C6D-44BB-445D-9B1B-5E87B69114BF Q38637751-51A65EF8-8231-4B79-9C9C-0595A777F3A8 Q38888345-92DD443F-9D45-413C-8914-853F22A74ECE Q41683998-CD9D417E-D269-46CC-A2B5-80BC545C395D Q43529077-B7D77A72-0262-486C-9BF5-668D353BCBAD Q44591373-B5727F96-0B56-4224-8D99-0A9C3F1B3DA4 Q46256727-CBC141E3-CD72-4A4C-A15D-50ABF45C813D Q46834044-A983B733-A9CC-47B5-91D9-85C52EC5CF11 Q47194882-3225A5C1-E5A2-44F8-9D95-69D60023DF90 Q47232215-207299C6-42F3-4835-A2E2-3123E228B8D6 Q47396835-4EE0484A-132C-4B63-A664-24CF9A6946F5 Q48972059-2DDD92BA-6EFD-4EF9-A63C-88CBDC64194D

P2860

Role of the copper transporter, CTR1, in platinum-induced ototoxicity.

http://www.wikidata.org/entity/Q30477867

description

2010 nî lūn-bûn

@nan

2010 թուականի Յուլիսին հրատարակուած գիտական յօդուած

@hyw

2010 թվականի հուլիսին հրատարակված գիտական հոդված

@hy

2010年の論文

@ja

2010年論文

@yue

2010年論文

@zh-hant

2010年論文

@zh-hk

2010年論文

@zh-mo

2010年論文

@zh-tw

2010年论文

@wuu

name

Role of the copper transporter, CTR1, in platinum-induced ototoxicity.

@ast

Role of the copper transporter, CTR1, in platinum-induced ototoxicity.

@en

type

label

Role of the copper transporter, CTR1, in platinum-induced ototoxicity.

@ast

Role of the copper transporter, CTR1, in platinum-induced ototoxicity.

@en

prefLabel

Role of the copper transporter, CTR1, in platinum-induced ototoxicity.

@ast

Role of the copper transporter, CTR1, in platinum-induced ototoxicity.

@en

P1433

Q30477867-DB21ADE9-6871-4CCF-817B-2872677A2AEE

P1476

Q30477867-CEDA39C7-B5E4-4929-9C02-09A9F4D4C478

P2093

Q30477867-9119759A-7EA3-421B-9E35-74AC899C98C4

Q30477867-AAC98EB8-4626-4871-89A3-92516FD7E065

Q30477867-B551F48E-AE54-4D27-A16C-A6FF8BD6EBFE

Q30477867-CC1B95C2-56F1-4E1F-BC01-F655D3E48AF9

Q30477867-F02EE97F-3B22-4326-9447-5711BD25D24C

Q30477867-F7187D5D-D6DA-46C1-BC6C-2ADAF2595E97

P2860

Q30477867-04387A84-05C8-4B2F-A4F9-47C7260779FB

Q30477867-0EF5C233-0C5F-483F-BC5B-815A6BADFE5A

Q30477867-11C1B583-6C4B-452B-97AF-9A9B4B509E28

Q30477867-154DBED3-4633-4657-81C6-76BF2067C86A

Q30477867-2C55F2BF-21A1-4695-A9C6-9A61E347541B

Q30477867-3D15B690-B6E2-41AF-90D9-D49767BE05A9

Q30477867-51710D76-3D51-4266-9E09-D6BF5432FAC4

Q30477867-634AD18C-83B2-4865-929B-C137C707B3CB

Q30477867-63D6D46A-77D7-4479-8708-2246F74026CD

Q30477867-6563BCAB-8144-429B-B728-EB2A30CEDDF9

P304

Q30477867-32D62E28-8927-4020-A258-A4A1186894CF

P31

Q30477867-29A768E7-8DC9-49BE-A088-F717B2821D7B

P356

Q30477867-501F997F-82BF-44A6-B519-8D1D6AF0E6A5

P407

Q30477867-A686C355-A10D-4D1F-AEB3-AA69E0D5A37B

P433

Q30477867-4D09D1BB-22C6-48B9-9F17-98BB2F21FAAD

P478

Q30477867-6214F7A0-003C-4B1F-8B6A-29D07C9F9E87

P577

Q30477867-4100487A-B708-407B-BC95-2F80C314FF96

P5875

Q30477867-3C4AC69E-1C1C-4E1B-8402-207E48D38249

P698

Q30477867-AA180C6B-BC11-4187-83C1-DBF04060D0DC

P932

Q30477867-E6BE7F00-3474-4241-A24C-4BC32AF23486

P356

JNEUROSCI.1544-10.2010

P1433

Journal of Neuroscience

P1476

Role of the copper transporter, CTR1, in platinum-induced ototoxicity.

@en

P2093

Alexandra G Ianculescu

http://www.w3.org/2001/XMLSchema#string

Ethan G Geier

http://www.w3.org/2001/XMLSchema#string

Kathleen M Giacomini

http://www.w3.org/2001/XMLSchema#string

Lawrence R Lustig

http://www.w3.org/2001/XMLSchema#string

Omar Akil

http://www.w3.org/2001/XMLSchema#string

Swati S More

http://www.w3.org/2001/XMLSchema#string

P2860

Drug screening for hearing loss: using the zebrafish lateral line to screen for drugs that prevent and cause hearing loss.

Organic cation transporter 2 mediates cisplatin-induced oto- and nephrotoxicity and is a target for protective interventions.

Comparative adverse effect profiles of platinum drugs.

Uptake of the anticancer drug cisplatin mediated by the copper transporter Ctr1 in yeast and mammals.

Mechanisms of cisplatin-induced ototoxicity and prevention.

Pharmacological and physiological functions of the polyspecific organic cation transporters: OCT1, 2, and 3 (SLC22A1-3).

Role of organic cation transporters in the renal handling of therapeutic agents and xenobiotics.

Essential role for mammalian copper transporter Ctr1 in copper homeostasis and embryonic development.

Evidence that cisplatin-induced auditory damage is attenuated by downregulation of pro-inflammatory cytokines via Nrf2/HO-1

The copper transporter Ctr1 contributes to cisplatin uptake by renal tubular cells during cisplatin nephrotoxicity.

P304

9500-9509

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1523/JNEUROSCI.1544-10.2010

http://www.w3.org/2001/XMLSchema#string

P407

P433

28

http://www.w3.org/2001/XMLSchema#string

P478

30

http://www.w3.org/2001/XMLSchema#string

P577

2010-07-01T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

45188407

http://www.w3.org/2001/XMLSchema#string

P698

20631178

http://www.w3.org/2001/XMLSchema#string

P932

2949060

http://www.w3.org/2001/XMLSchema#string