Imaging analysis reveals mechanistic differences between first- and second-phase insulin exocytosis.
about
Transcellular neuroligin-2 interactions enhance insulin secretion and are integral to pancreatic β cell functionInvolvement of creatine kinase B in hepatitis C virus genome replication through interaction with the viral NS4A proteinSyntaxin 4 up-regulation increases efficiency of insulin release in pancreatic islets from humans with and without type 2 diabetes mellitusDistinct initial SNARE configurations underlying the diversity of exocytosisSignaling mechanisms of glucose-induced F-actin remodeling in pancreatic islet β cellsUnifying concepts in stimulus-secretion coupling in endocrine cells and some implications for therapeutics.Preferential release of newly synthesized insulin assessed by a multi-label reporter system using pancreatic β-cell line MIN6Munc18c depletion selectively impairs the sustained phase of insulin releaseDeletion of CDKAL1 affects mitochondrial ATP generation and first-phase insulin exocytosisInsulin biosynthetic interaction network component, TMEM24, facilitates insulin reserve pool releaseDistinct actions of Rab3 and Rab27 GTPases on late stages of exocytosis of insulin.Multivesicular exocytosis in rat pancreatic beta cells.Munc18b is a major mediator of insulin exocytosis in rat pancreatic β-cellsGlucose principally regulates insulin secretion in mouse islets by controlling the numbers of granule fusion events per cellSubcellular glucose exposure biases the spatial distribution of insulin granules in single pancreatic beta cells.Insulin secretion from beta cells in intact mouse islets is targeted towards the vasculature.Aged insulin granules display reduced microtubule-dependent mobility and are disposed within actin-positive multigranular bodiesGαo represses insulin secretion by reducing vesicular docking in pancreatic beta-cells.Exocytosis mechanisms underlying insulin release and glucose uptake: conserved roles for Munc18c and syntaxin 4Doc2b enrichment enhances glucose homeostasis in mice via potentiation of insulin secretion and peripheral insulin sensitivityMunc18b Increases Insulin Granule Fusion, Restoring Deficient Insulin Secretion in Type-2 Diabetes Human and Goto-Kakizaki Rat Islets with Improvement in Glucose Homeostasis.High prevalence of diabetes and pre-diabetes in adults with Williams syndrome.The N- and C-terminal domains of tomosyn play distinct roles in soluble N-ethylmaleimide-sensitive factor attachment protein receptor binding and fusion regulationEvaluating protocols for embryonic stem cell differentiation into insulin-secreting beta-cells using insulin II-GFP as a specific and noninvasive reporter.Acute inhibition of PI3K-PDK1-Akt pathway potentiates insulin secretion through upregulation of newcomer granule fusions in pancreatic β-cells.Properties of ribbon and non-ribbon release from rod photoreceptors revealed by visualizing individual synaptic vesiclesSyntaxin 1A regulates surface expression of beta-cell ATP-sensitive potassium channels.Altered pancreatic islet function and morphology in mice lacking the Beta-cell surface protein neuroligin-2.Dynamics of insulin secretion and the clinical implications for obesity and diabetesContact-induced clustering of syntaxin and munc18 docks secretory granules at the exocytosis site.Doc2b serves as a scaffolding platform for concurrent binding of multiple Munc18 isoforms in pancreatic islet β-cellsCoupling of metabolic, second messenger pathways and insulin granule dynamics in pancreatic beta-cells: a computational analysisGelsolin associates with the N terminus of syntaxin 4 to regulate insulin granule exocytosis.Survey of Red Fluorescence Proteins as Markers for Secretory Granule ExocytosisSyntaxin-3 Binds and Regulates Both R- and L-Type Calcium Channels in Insulin-Secreting INS-1 832/13 Cells.Evolving insights regarding mechanisms for the inhibition of insulin release by norepinephrine and heterotrimeric G proteins.APPL1 potentiates insulin secretion in pancreatic β cells by enhancing protein kinase Akt-dependent expression of SNARE proteins in miceMunc18-1 regulates first-phase insulin release by promoting granule docking to multiple syntaxin isoformsDoc2b is a key effector of insulin secretion and skeletal muscle insulin sensitivityCAPS and syntaxin dock dense core vesicles to the plasma membrane in neurons
P2860
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P2860
Imaging analysis reveals mechanistic differences between first- and second-phase insulin exocytosis.
description
2007 nî lūn-bûn
@nan
2007 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
name
Imaging analysis reveals mecha ...... cond-phase insulin exocytosis.
@ast
Imaging analysis reveals mecha ...... cond-phase insulin exocytosis.
@en
type
label
Imaging analysis reveals mecha ...... cond-phase insulin exocytosis.
@ast
Imaging analysis reveals mecha ...... cond-phase insulin exocytosis.
@en
prefLabel
Imaging analysis reveals mecha ...... cond-phase insulin exocytosis.
@ast
Imaging analysis reveals mecha ...... cond-phase insulin exocytosis.
@en
P2093
P2860
P921
P356
P1476
Imaging analysis reveals mecha ...... cond-phase insulin exocytosis.
@en
P2093
Hayato Kawakami
Junko Kawai
Kimio Akagawa
Mica Ohara-Imaizumi
Satsuki Matsushima
Shinya Nagamatsu
Tadashi Okamura
Takashi Watanabe
Tomonori Fujiwara
Yoko Nakamichi
P2860
P304
P356
10.1083/JCB.200608132
P407
P577
2007-05-14T00:00:00Z