APPL1 potentiates insulin secretion in pancreatic β cells by enhancing protein kinase Akt-dependent expression of SNARE proteins in mice
about
APPL endosomes are not obligatory endocytic intermediates but act as stable cargo-sorting compartments.Absence of Appl2 sensitizes endotoxin shock through activation of PI3K/Akt pathway.Deficiency of APPL1 in mice impairs glucose-stimulated insulin secretion through inhibition of pancreatic beta cell mitochondrial function.Dual functions of adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1 (APPL1) in insulin signaling and insulin secretion.Nanoscale Landscape of Phosphoinositides Revealed by Specific Pleckstrin Homology (PH) Domains Using Single-molecule Superresolution Imaging in the Plasma Membrane.Syntaxin 1A mediates isoflurane but not hypoxia preconditioning-induced alleviation of hypoxia-reoxygenation injury in rat cardiomyocytesAppl1 and Appl2 are Expendable for Mouse Development But Are Essential for HGF-Induced Akt Activation and Migration in Mouse Embryonic Fibroblasts.Expression of APPL1 is correlated with clinicopathologic characteristics and poor prognosis in patients with gastric cancer.The MDM2-p53-pyruvate carboxylase signalling axis couples mitochondrial metabolism to glucose-stimulated insulin secretion in pancreatic β-cellsAPPL proteins modulate DNA repair and radiation survival of pancreatic carcinoma cells by regulating ATM.Direct effects of adipokines on the heart: focus on adiponectin.Myosin VI and its cargo adaptors - linking endocytosis and autophagy.APPL1 prevents pancreatic beta cell death and inflammation by dampening NFκB activation in a mouse model of type 1 diabetes.I2020T mutant LRRK2 iPSC-derived neurons in the Sagamihara family exhibit increased Tau phosphorylation through the AKT/GSK-3β signaling pathway.Gelam Honey Attenuates the Oxidative Stress-Induced Inflammatory Pathways in Pancreatic Hamster Cells.Effect of gelam honey on the oxidative stress-induced signaling pathways in pancreatic hamster cells.TRAF6-mediated ubiquitination of APPL1 enhances hepatic actions of insulin by promoting the membrane translocation of Akt.Adaptor Protein APPL2 Affects Adult Antidepressant Behaviors and Hippocampal Neurogenesis via Regulating the Sensitivity of Glucocorticoid Receptor.APPL1 transgenic mice are protected from high-fat diet-induced cardiac dysfunction.SNARE proteins in membrane trafficking.From white to beige: a new hypothalamic pathway.
P2860
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P2860
APPL1 potentiates insulin secretion in pancreatic β cells by enhancing protein kinase Akt-dependent expression of SNARE proteins in mice
description
2012 nî lūn-bûn
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2012年の論文
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2012年論文
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2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
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2012年论文
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name
APPL1 potentiates insulin secr ...... sion of SNARE proteins in mice
@ast
APPL1 potentiates insulin secr ...... sion of SNARE proteins in mice
@en
type
label
APPL1 potentiates insulin secr ...... sion of SNARE proteins in mice
@ast
APPL1 potentiates insulin secr ...... sion of SNARE proteins in mice
@en
prefLabel
APPL1 potentiates insulin secr ...... sion of SNARE proteins in mice
@ast
APPL1 potentiates insulin secr ...... sion of SNARE proteins in mice
@en
P2093
P2860
P356
P1476
APPL1 potentiates insulin secr ...... sion of SNARE proteins in mice
@en
P2093
Donghai Wu
Gary Sweeney
Jialiang Zhang
Karen S L Lam
Kenneth K Y Cheng
Ruby L C Hoo
P2860
P304
P356
10.1073/PNAS.1202435109
P407
P577
2012-05-07T00:00:00Z