Intermediate-affinity LFA-1 binds alpha-actinin-1 to control migration at the leading edge of the T cell. - Wikidata - wikimedia - TriplyDB

Intermediate-affinity LFA-1 binds alpha-actinin-1 to control migration at the leading edge of the T cell.

Intermediate-affinity LFA-1 binds alpha-actinin-1 to control migration at the leading edge of the T cell.

http://www.wikidata.org/entity/Q30480879

about

Wiskott-Aldrich syndrome protein controls antigen-presenting cell-driven CD4+ T-cell motility by regulating adhesion to intercellular adhesion molecule-1 T Lymphocyte Migration: An Action Movie Starring the Actin and Associated Actors.Leukocyte integrins: role in leukocyte recruitment and as therapeutic targets in inflammatory disease Mechanical regulation of T-cell functions The Gαq/11 proteins contribute to T lymphocyte migration by promoting turnover of integrin LFA-1 through recycling Calpain 2 controls turnover of LFA-1 adhesions on migrating T lymphocytes Mst1 directs Myosin IIa partitioning of low and higher affinity integrins during T cell migration NMR solution conformations and interactions of integrin alphaLbeta2 cytoplasmic tails Stable Coordination of the Inhibitory Ca2+ Ion at the Metal Ion-Dependent Adhesion Site in Integrin CD11b/CD18 by an Antibody-Derived Ligand Aspartate: Implications for Integrin Regulation and Structure-Based Drug Design Rolling on E- or P-selectin induces the extended but not high-affinity conformation of LFA-1 in neutrophils Coordinated RhoA signaling at the leading edge and uropod is required for T cell transendothelial migration.Integrins in cell migration--the actin connection.Activated integrin VLA-4 localizes to the lamellipodia and mediates T cell migration on VCAM-1.Lymphocyte crawling and transendothelial migration require chemokine triggering of high-affinity LFA-1 integrin.Distinct roles for LFA-1 affinity regulation during T-cell adhesion, diapedesis, and interstitial migration in lymph nodes.Forcing switch from short- to intermediate- and long-lived states of the alphaA domain generates LFA-1/ICAM-1 catch bonds Comparison of immortalized bEnd5 and primary mouse brain microvascular endothelial cells as in vitro blood-brain barrier models for the study of T cell extravasation.JAK tyrosine kinases promote hierarchical activation of Rho and Rap modules of integrin activation Phosphorylation of Rab5a protein by protein kinase Cϵ is crucial for T-cell migration.Topographic prominence as a method for cluster identification in single-molecule localisation data.Conformational stability analyses of alpha subunit I domain of LFA-1 and Mac-1 Requirement of open headpiece conformation for activation of leukocyte integrin alphaXbeta2.A novel pathway of rapid TLR-triggered activation of integrin-dependent leukocyte adhesion that requires Rap1 GTPase.Regulation of integrin affinity on cell surfaces A role for Rap2 in recycling the extended conformation of LFA-1 during T cell migration.Leukocyte arrest: Biomechanics and molecular mechanisms of β2 integrin activation SKAP-55, SKAP-55-related and ADAP adaptors modulate integrin-mediated immune-cell adhesion.Tyrosine phosphorylation of CD13 regulates inflammatory cell-cell adhesion and monocyte trafficking.Regulation of integrin activity and signalling SHARPIN regulates uropod detachment in migrating lymphocytes.New insights into the regulation and function of serine/threonine kinases in T lymphocytes.The ins and outs of leukocyte integrin signaling.Rolling cell adhesion The insider's guide to leukocyte integrin signalling and function.LFA-1 fine-tuning by cathepsin X.The leucocyte β2 (CD18) integrins: the structure, functional regulation and signalling properties.Going against the tide--how encephalitogenic T cells breach the blood-brain barrier.Cofilin: a redox sensitive mediator of actin dynamics during T-cell activation and migration.Actin cytoskeleton control of the comings and goings of T lymphocytes.Adaptor regulation of LFA-1 signaling in T lymphocyte migration: Potential druggable targets for immunotherapies?

P2860

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P2860

Intermediate-affinity LFA-1 binds alpha-actinin-1 to control migration at the leading edge of the T cell.

http://www.wikidata.org/entity/Q30480879

description

2007 nî lūn-bûn

@nan

2007 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2007 թվականի դեկտեմբերին հրատարակված գիտական հոդված

@hy

2007年の論文

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2007年論文

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2007年論文

@zh-hant

2007年論文

@zh-hk

2007年論文

@zh-mo

2007年論文

@zh-tw

2007年论文

@wuu

name

Intermediate-affinity LFA-1 bi ...... he leading edge of the T cell.

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Intermediate-affinity LFA-1 bi ...... he leading edge of the T cell.

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type

label

Intermediate-affinity LFA-1 bi ...... he leading edge of the T cell.

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Intermediate-affinity LFA-1 bi ...... he leading edge of the T cell.

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prefLabel

Intermediate-affinity LFA-1 bi ...... he leading edge of the T cell.

@ast

Intermediate-affinity LFA-1 bi ...... he leading edge of the T cell.

@en

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SJ.EMBOJ.7601959

P1433

The EMBO Journal

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Intermediate-affinity LFA-1 bi ...... he leading edge of the T cell.

@en

P2093

Alastair Nicol

http://www.w3.org/2001/XMLSchema#string

Alison McDowall

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Andrew Smith

http://www.w3.org/2001/XMLSchema#string

Daniel Zicha

http://www.w3.org/2001/XMLSchema#string

Nancy Hogg

http://www.w3.org/2001/XMLSchema#string

Paula Stanley

http://www.w3.org/2001/XMLSchema#string

P2860

Crystal structure of the extracellular segment of integrin alpha Vbeta3

Structural basis of integrin activation by talin

Functional role of alpha-actinin, PI 3-kinase and MEK1/2 in insulin-like growth factor I receptor kinase regulated motility of human breast carcinoma cells

Activation of human neutrophils induces an interaction between the integrin beta 2-subunit (CD18) and the actin binding protein alpha-actinin

Cysteine-rich module structure reveals a fulcrum for integrin rearrangement upon activation

Nascent focal adhesions are responsible for the generation of strong propulsive forces in migrating fibroblasts

Integrin avidity regulation: are changes in affinity and conformation underemphasized?

T-cell priming by dendritic cells in lymph nodes occurs in three distinct phases

Structural basis of integrin regulation and signaling

Differential dynamics of alpha 5 integrin, paxillin, and alpha-actinin during formation and disassembly of adhesions in migrating cells

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62-75

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scholarly article

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10.1038/SJ.EMBOJ.7601959

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1

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27

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2007-12-13T00:00:00Z

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5768289

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18079697

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2147999

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