Neurobehavioral abnormalities in the dysbindin-1 mutant, sandy, on a C57BL/6J genetic background. - Wikidata - wikimedia - TriplyDB

Neurobehavioral abnormalities in the dysbindin-1 mutant, sandy, on a C57BL/6J genetic background.

Neurobehavioral abnormalities in the dysbindin-1 mutant, sandy, on a C57BL/6J genetic background.

http://www.wikidata.org/entity/Q30481233

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The schizophrenia susceptibility factor dysbindin and its associated complex sort cargoes from cell bodies to the synapse Nucleocytoplasmic shuttling of dysbindin-1, a schizophrenia-related protein, regulates synapsin I expression The dysbindin-containing complex (BLOC-1) in brain: developmental regulation, interaction with SNARE proteins and role in neurite outgrowth Schizophrenia susceptibility gene dysbindin regulates glutamatergic and dopaminergic functions via distinctive mechanisms in Drosophila The molecular basis of cognitive deficits in pervasive developmental disorders Behavioral abnormalities observed in Zfhx2-deficient mice.Gene × Environment Interactions in Schizophrenia: Evidence from Genetic Mouse Models Dysbindin promotes the post-endocytic sorting of G protein-coupled receptors to lysosomes Role of dysbindin in dopamine receptor trafficking and cortical GABA function Neurodevelopmental animal models of schizophrenia: role in novel drug discovery and development Behavioral characterization of mice overexpressing human dysbindin-1.Animal models of schizophrenia.Dysbindin-1 modulates prefrontal cortical activity and schizophrenia-like behaviors via dopamine/D2 pathways.Dysbindin-1 mutant mice implicate reduced fast-phasic inhibition as a final common disease mechanism in schizophrenia.Dysbindin-containing complexes and their proposed functions in brain: from zero to (too) many in a decade.Contribution of nonprimate animal models in understanding the etiology of schizophrenia.Modeling the positive symptoms of schizophrenia in genetically modified mice: pharmacology and methodology aspects Dysbindin-1 loss compromises NMDAR-dependent synaptic plasticity and contextual fear conditioning.Mutations in the BLOC-1 subunits dysbindin and muted generate divergent and dosage-dependent phenotypes.Genetic modifiers of abnormal organelle biogenesis in a Drosophila model of BLOC-1 deficiency.Reduced rate of neural differentiation in the dentate gyrus of adult dysbindin null (sandy) mouse Synaptic dysbindin-1 reductions in schizophrenia occur in an isoform-specific manner indicating their subsynaptic location.A polymorphism in the dysbindin gene (DTNBP1) associated with multiple psychiatric disorders including schizophrenia.Neuroplasticity signaling pathways linked to the pathophysiology of schizophrenia.Dysbindin and Schizophrenia: it's dopamine and glutamate all over again.CHRONIC NEONATAL DIAZOXIDE THERAPY IS NOT ASSOCIATED WITH ADVERSE EFFECTS The Schizophrenia-Related Protein Dysbindin-1A Is Degraded and Facilitates NF-Kappa B Activity in the Nucleus Quantitative proteomic and genetic analyses of the schizophrenia susceptibility factor dysbindin identify novel roles of the biogenesis of lysosome-related organelles complex 1.Loss of dysbindin-1 in mice impairs reward-based operant learning by increasing impulsive and compulsive behavior Epistatic interaction between COMT and DTNBP1 modulates prefrontal function in mice and in humans Effects of sex and DTNBP1 (dysbindin) null gene mutation on the developmental GluN2B-GluN2A switch in the mouse cortex and hippocampus.Increased dysbindin-1B isoform expression in schizophrenia and its propensity in aggresome formation.The Proteome of BLOC-1 Genetic Defects Identifies the Arp2/3 Actin Polymerization Complex to Function Downstream of the Schizophrenia Susceptibility Factor Dysbindin at the Synapse The schizophrenia susceptibility gene DTNBP1 modulates AMPAR synaptic transmission and plasticity in the hippocampus of juvenile DBA/2J mice.Evodiamine improves congnitive abilities in SAMP8 and APP(swe)/PS1(ΔE9) transgenic mouse models of Alzheimer's disease.Dysregulation of Specialized Delay/Interference-Dependent Working Memory Following Loss of Dysbindin-1A in Schizophrenia-Related Phenotypes.Loss of dysbindin-1, a risk gene for schizophrenia, leads to impaired group 1 metabotropic glutamate receptor function in mice.Dysbindin modulates prefrontal cortical glutamatergic circuits and working memory function in mice.Src kinase as a mediator of convergent molecular abnormalities leading to NMDAR hypoactivity in schizophrenia.Schizophrenia: the "BLOC" may be in the endosomes.

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Neurobehavioral abnormalities in the dysbindin-1 mutant, sandy, on a C57BL/6J genetic background.

http://www.wikidata.org/entity/Q30481233

description

2009 nî lūn-bûn

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2009 թուականի Փետրուարին հրատարակուած գիտական յօդուած

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2009 թվականի փետրվարին հրատարակված գիտական հոդված

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2009年の論文

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2009年論文

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2009年論文

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2009年論文

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2009年論文

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2009年論文

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2009年论文

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Neurobehavioral abnormalities ...... a C57BL/6J genetic background.

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Neurobehavioral abnormalities ...... a C57BL/6J genetic background.

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Neurobehavioral abnormalities ...... a C57BL/6J genetic background.

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Neurobehavioral abnormalities ...... a C57BL/6J genetic background.

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Neurobehavioral abnormalities ...... a C57BL/6J genetic background.

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Neurobehavioral abnormalities ...... a C57BL/6J genetic background.

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J.1601-183X.2009.00477.X

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Genes, Brain and Behavior

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Neurobehavioral abnormalities ...... a C57BL/6J genetic background.

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A M Tucker

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P2860

Association between the DTNBP1 gene and intelligence: a case-control study in young patients with schizophrenia and related disorders and unaffected siblings

Dysbindin-1 is a synaptic and microtubular protein that binds brain snapin

Behavioral and regulatory abnormalities in mice deficient in the NPAS1 and NPAS3 transcription factors.

Neuregulin 1 and susceptibility to schizophrenia.

Hermansky-Pudlak syndrome type 7 (HPS-7) results from mutant dysbindin, a member of the biogenesis of lysosome-related organelles complex 1 (BLOC-1)

Conditional calcineurin knockout mice exhibit multiple abnormal behaviors related to schizophrenia

Systematic meta-analyses and field synopsis of genetic association studies in schizophrenia: the SzGene database

The essential role of hippocampal CA1 NMDA receptor-dependent synaptic plasticity in spatial memory

Dysbindin, a novel coiled-coil-containing protein that interacts with the dystrobrevins in muscle and brain

Mice with reduced NMDA receptor expression display behaviors related to schizophrenia

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