Systematic behavioral evaluation of Huntington's disease transgenic and knock-in mouse models. - Wikidata - wikimedia - TriplyDB

Systematic behavioral evaluation of Huntington's disease transgenic and knock-in mouse models.

Systematic behavioral evaluation of Huntington's disease transgenic and knock-in mouse models.

http://www.wikidata.org/entity/Q30483013

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Mood disorders in Huntington's disease: from behavior to cellular and molecular mechanisms Threonine 56 phosphorylation of Bcl-2 is required for LRRK2 G2019S-induced mitochondrial depolarization and autophagy Mouse models of polyglutamine diseases: review and data table. Part I Pluripotent stem cells models for Huntington's disease: prospects and challenges Disease-toxicant interactions in manganese exposed Huntington disease mice: early changes in striatal neuron morphology and dopamine metabolism Cognitive Training at a Young Age Attenuates Deficits in the zQ175 Mouse Model of HD.Human-to-mouse prion-like propagation of mutant huntingtin protein.AAV-dominant negative tumor necrosis factor (DN-TNF) gene transfer to the striatum does not rescue medium spiny neurons in the YAC128 mouse model of Huntington's disease Effects of deletion of mutant huntingtin in steroidogenic factor 1 neurons on the psychiatric and metabolic phenotype in the BACHD mouse model of Huntington disease Rodent models in neuroscience research: is it a rat race?Sex Differences in Circadian Dysfunction in the BACHD Mouse Model of Huntington's Disease Homeostatic adaptations in brain energy metabolism in mouse models of Huntington disease A broad phenotypic screen identifies novel phenotypes driven by a single mutant allele in Huntington's disease CAG knock-in mice.Oxygen consumption deficit in Huntington disease mouse brain under metabolic stress Assessment of motor function, sensory motor gating and recognition memory in a novel BACHD transgenic rat model for huntington disease.High-Throughput Automated Phenotyping of Two Genetic Mouse Models of Huntington's Disease Characterization of HTT inclusion size, location, and timing in the zQ175 mouse model of Huntington's disease: an in vivo high-content imaging study Comprehensive Analysis of the 16p11.2 Deletion and Null Cntnap2 Mouse Models of Autism Spectrum Disorder.Deficits in a Simple Visual Go/No-go Discrimination Task in Two Mouse Models of Huntington's Disease Onset and progression of behavioral and molecular phenotypes in a novel congenic R6/2 line exhibiting intergenerational CAG repeat stability.Comprehensive behavioral testing in the R6/2 mouse model of Huntington's disease shows no benefit from CoQ10 or minocycline Premutation in the Fragile X Mental Retardation 1 (FMR1) Gene Affects Maternal Zn-milk and Perinatal Brain Bioenergetics and Scaffolding.Serine 421 regulates mutant huntingtin toxicity and clearance in mice.Genetic models of sensorimotor gating: relevance to neuropsychiatric disorders.Genetic background modulates behavioral impairments in R6/2 mice and suggests a role for dominant genetic modifiers in Huntington’s disease pathogenesis.Human embryonic stem cell-derived GABA neurons correct locomotion deficits in quinolinic acid-lesioned mice.The Huntington disease protein accelerates breast tumour development and metastasis through ErbB2/HER2 signalling.A fully humanized transgenic mouse model of Huntington disease.A potent and selective Sirtuin 1 inhibitor alleviates pathology in multiple animal and cell models of Huntington's disease.Neuronal targets for reducing mutant huntingtin expression to ameliorate disease in a mouse model of Huntington's disease Dysfunctions in circadian behavior and physiology in mouse models of Huntington's disease.Motivational, proteostatic and transcriptional deficits precede synapse loss, gliosis and neurodegeneration in the B6.HttQ111/+ model of Huntington's disease.The expanded CAG repeat in the huntingtin gene as target for therapeutic RNA modulation throughout the HD mouse brain.Huntingtin acts non cell-autonomously on hippocampal neurogenesis and controls anxiety-related behaviors in adult mouse Formation of polyglutamine inclusions in a wide range of non-CNS tissues in the HdhQ150 knock-in mouse model of Huntington's disease.Probing the metabolic aberrations underlying mutant huntingtin toxicity in yeast and assessing their degree of preservation in humans and mice.Serines 13 and 16 are critical determinants of full-length human mutant huntingtin induced disease pathogenesis in HD mice.Composite primary neuronal high-content screening assay for Huntington's disease incorporating non-cell-autonomous interactions.A small molecule p75NTR ligand normalizes signalling and reduces Huntington's disease phenotypes in R6/2 and BACHD mice.A restricted population of CB1 cannabinoid receptors with neuroprotective activity

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Systematic behavioral evaluation of Huntington's disease transgenic and knock-in mouse models.

http://www.wikidata.org/entity/Q30483013

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2009 nî lūn-bûn

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2009 թուականի Մայիսին հրատարակուած գիտական յօդուած

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2009 թվականի մայիսին հրատարակված գիտական հոդված

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2009年の論文

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2009年論文

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2009年論文

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2009年論文

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2009年論文

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2009年論文

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2009年论文

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Systematic behavioral evaluati ...... nic and knock-in mouse models.

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Systematic behavioral evaluati ...... nic and knock-in mouse models.

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Systematic behavioral evaluati ...... nic and knock-in mouse models.

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Systematic behavioral evaluati ...... nic and knock-in mouse models.

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Systematic behavioral evaluati ...... nic and knock-in mouse models.

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J.NBD.2009.05.007

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Neurobiology of Disease

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Systematic behavioral evaluati ...... nic and knock-in mouse models.

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Allan Tobin

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Bassem F El-Khodor

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Benjamin Zahasky

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Christina Leahy

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Daniela Brunner

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David Howland

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Ethan Signer

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Janet Leeds

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Larry Park

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Liliana Menalled

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P2860

Impaired prepulse inhibition of acoustic and tactile startle response in patients with Huntington's disease.

A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes.

Inbred strain differences in prepulse inhibition of the mouse startle response

Analysis of a very large trinucleotide repeat in a patient with juvenile Huntington's disease

Neurological abnormalities in a knock-in mouse model of Huntington's disease

Early motor dysfunction and striosomal distribution of huntingtin microaggregates in Huntington's disease knock-in mice

Exon 1 of the HD gene with an expanded CAG repeat is sufficient to cause a progressive neurological phenotype in transgenic mice

Wild-type huntingtin ameliorates striatal neuronal atrophy but does not prevent other abnormalities in the YAC128 mouse model of Huntington disease.

Wheel running from a juvenile age delays onset of specific motor deficits but does not alter protein aggregate density in a mouse model of Huntington's disease.

Retinal degeneration in the rd mouse is caused by a defect in the beta subunit of rod cGMP-phosphodiesterase.

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319-336

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10.1016/J.NBD.2009.05.007

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3

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35

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Marcy E. MacDonald

A Jennifer Morton

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2009-05-21T00:00:00Z

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26236004

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19464370

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Huntington disease

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2728344

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