Absence epilepsy in apathetic, a spontaneous mutant mouse lacking the h channel subunit, HCN2 - Wikidata - wikimedia - TriplyDB

Absence epilepsy in apathetic, a spontaneous mutant mouse lacking the h channel subunit, HCN2

Absence epilepsy in apathetic, a spontaneous mutant mouse lacking the h channel subunit, HCN2

http://www.wikidata.org/entity/Q30486037

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Epileptiform activity and cognitive deficits in SNAP-25(+/-) mice are normalized by antiepileptic drugs Deletion of the hyperpolarization-activated cyclic nucleotide-gated channel auxiliary subunit TRIP8b impairs hippocampal Ih localization and function and promotes antidepressant behavior in mice.BACE1-/- mice exhibit seizure activity that does not correlate with sodium channel level or axonal localization Decreased viability and absence-like epilepsy in mice lacking or deficient in the GABAA receptor α1 subunit.Reduction of thalamic and cortical Ih by deletion of TRIP8b produces a mouse model of human absence epilepsy.The Ih Channel Gene Promotes Synaptic Transmission and Coordinated Movement in Drosophila melanogaster.Ih current is necessary to maintain normal dopamine fluctuations and sleep consolidation in Drosophila.HCN channelopathy in external globus pallidus neurons in models of Parkinson's disease.HCN channels in behavior and neurological disease: too hyper or not active enough?Low brain ascorbic acid increases susceptibility to seizures in mouse models of decreased brain ascorbic acid transport and Alzheimer's disease The fast and slow ups and downs of HCN channel regulation.How can we identify ictal and interictal abnormal activity?Decreased hyperpolarization-activated currents in layer 5 pyramidal neurons enhances excitability in focal cortical dysplasia.Thalamocortical neurons display suppressed burst-firing due to an enhanced Ih current in a genetic model of absence epilepsy HCN channelopathies: pathophysiology in genetic epilepsy and therapeutic implications An N-terminal deletion variant of HCN1 in the epileptic WAG/Rij strain modulates HCN current densities.Regulation of epileptiform discharges in rat neocortex by HCN channels Alternatively spliced isoforms of TRIP8b differentially control h channel trafficking and function.Novel association of early onset hepatocellular carcinoma with transaldolase deficiency Genomic biomarkers of SUDEP in brain and heart.Towards an integrated view of HCN channel role in epilepsy.HCN channels--modulators of cardiac and neuronal excitability.Dysfunctional HCN ion channels in neurological diseases.Heat induced temperature dysregulation and seizures in Dravet Syndrome/GEFS+ Gabrg2+/Q390X mice.Two approaches reveal a new paradigm of 'switchable or genetics-influenced allele-specific DNA methylation' with potential in human disease.Gain-of-function HCN2 variants in genetic epilepsy.Allostery between two binding sites in the ion channel subunit TRIP8b confers binding specificity to HCN channels.Roles of the subthalamic nucleus and subthalamic HCN channels in absence seizures.Loss of HCN2 leads to delayed gastrointestinal motility and reduced energy intake in mice.A Loss-of-Function Mutation Associated With Familial Benign Myoclonic Epilepsy in Infancy Causes Increased Neuronal Excitability

P2860

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P2860

Absence epilepsy in apathetic, a spontaneous mutant mouse lacking the h channel subunit, HCN2

http://www.wikidata.org/entity/Q30486037

description

2008 nî lūn-bûn

@nan

2008 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2008 թվականի դեկտեմբերին հրատարակված գիտական հոդված

@hy

2008年の論文

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2008年論文

@yue

2008年論文

@zh-hant

2008年論文

@zh-hk

2008年論文

@zh-mo

2008年論文

@zh-tw

2008年论文

@wuu

name

Absence epilepsy in apathetic, ...... ng the h channel subunit, HCN2

@ast

Absence epilepsy in apathetic, ...... ng the h channel subunit, HCN2

@en

type

label

Absence epilepsy in apathetic, ...... ng the h channel subunit, HCN2

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Absence epilepsy in apathetic, ...... ng the h channel subunit, HCN2

@en

prefLabel

Absence epilepsy in apathetic, ...... ng the h channel subunit, HCN2

@ast

Absence epilepsy in apathetic, ...... ng the h channel subunit, HCN2

@en

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P356

J.NBD.2008.12.004

P1433

Neurobiology of Disease

P1476

Absence epilepsy in apathetic, ...... ng the h channel subunit, HCN2

@en

P2093

Ayman A Gheith

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Charles A LeDuc

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Dane M Chetkovich

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Efthia Tzilianos

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Minyoung Shin

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Rudolph L Leibel

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Stuart G Fischer

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Thomas C Jaramillo

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Wendy K Chung

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P2860

Identification of a gene encoding a hyperpolarization-activated pacemaker channel of brain

Alpha7 nicotinic receptor subunits are not necessary for hippocampal-dependent learning or sensorimotor gating: a behavioral characterization of Acra7-deficient mice.

Enhanced expression of a specific hyperpolarization-activated cyclic nucleotide-gated cation channel (HCN) in surviving dentate gyrus granule cells of human and experimental epileptic hippocampus

Immunohistochemical localization of Ih channel subunits, HCN1-4, in the rat brain

Increased excitability and inward rectification in layer V cortical pyramidal neurons in the epileptic mutant mouse Stargazer

Mislocalization of h channel subunits underlies h channelopathy in temporal lobe epilepsy.

Molecular and functional heterogeneity of hyperpolarization-activated pacemaker channels in the mouse CNS.

MRNA stability and the control of gene expression: implications for human disease.

A family of hyperpolarization-activated mammalian cation channels.

Early treatment suppresses the development of spike-wave epilepsy in a rat model

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499-508

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scholarly article

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10.1016/J.NBD.2008.12.004

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3

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P478

33

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Alan Seth Lewis

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2008-12-25T00:00:00Z

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19150498

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2643333

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