BACE1-/- mice exhibit seizure activity that does not correlate with sodium channel level or axonal localization - Wikidata - wikimedia - TriplyDB

BACE1-/- mice exhibit seizure activity that does not correlate with sodium channel level or axonal localization

BACE1-/- mice exhibit seizure activity that does not correlate with sodium channel level or axonal localization

http://www.wikidata.org/entity/Q30496432

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Stepping closer to treating Alzheimer's disease patients with BACE1 inhibitor drugs Proteolytic processing of Alzheimer's β-amyloid precursor protein The normal and pathologic roles of the Alzheimer's β-secretase, BACE1 Physiological Functions of the β-Site Amyloid Precursor Protein Cleaving Enzyme 1 and 2 BACE1 is necessary for experience-dependent homeostatic synaptic plasticity in visual cortex Function, therapeutic potential and cell biology of BACE proteases: current status and future prospects.BACE1 (β-secretase) inhibitors for the treatment of Alzheimer's disease APP knockout mice experience acute mortality as the result of ischemia.Targeting the β secretase BACE1 for Alzheimer's disease therapy.Reduced sodium channel Na(v)1.1 levels in BACE1-null mice Aβ reduction in BACE1 heterozygous null 5XFAD mice is associated with transgenic APP level Axonal and Schwann cell BACE1 is equally required for remyelination of peripheral nerves.The relevance of individual genetic background and its role in animal models of epilepsy The Alzheimer's β-secretase enzyme BACE1 is required for accurate axon guidance of olfactory sensory neurons and normal glomerulus formation in the olfactory bulb.The neural cell adhesion molecules L1 and CHL1 are cleaved by BACE1 protease in vivo β-Site amyloid precursor protein (APP)-cleaving enzyme 1 (BACE1)-deficient mice exhibit a close homolog of L1 (CHL1) loss-of-function phenotype involving axon guidance defects Neurological dysfunctions associated with altered BACE1-dependent Neuregulin-1 signaling.Inhibiting BACE1 to reverse synaptic dysfunctions in Alzheimer's disease.β-Secretase: its biology as a therapeutic target in diseases Structure-activity relationship of memapsin 2: implications on physiological functions and Alzheimer's disease Mechanisms that lessen benefits of β-secretase reduction in a mouse model of Alzheimer's disease.BACE1 regulates hippocampal astrogenesis via the Jagged1-Notch pathway.Functions of the Alzheimer's Disease Protease BACE1 at the Synapse in the Central Nervous System.Shared cognitive and behavioral impairments in epilepsy and Alzheimer's disease and potential underlying mechanisms.Genetic suppression of transgenic APP rescues Hypersynchronous network activity in a mouse model of Alzeimer's disease.Can BACE1 inhibition mitigate early axonal pathology in neurological diseases?The β-secretase enzyme BACE1 as a therapeutic target for Alzheimer's disease.Identification and biology of β-secretase.The Membrane-Bound Aspartyl Protease BACE1: Molecular and Functional Properties in Alzheimer's Disease and Beyond BACE1 as a therapeutic target in Alzheimer's disease: rationale and current status.BACE1 inhibitor drugs in clinical trials for Alzheimer's disease.Ion channel regulation by β-secretase BACE1 - enzymatic and non-enzymatic effects beyond Alzheimer's disease.The Alzheimer's β-secretase BACE1 localizes to normal presynaptic terminals and to dystrophic presynaptic terminals surrounding amyloid plaques.Models and detection of spontaneous recurrent seizures in laboratory rodents.Can brain impermeable BACE1 inhibitors serve as anti-CAA medicine?The E280A presenilin mutation reduces voltage-gated sodium channel levels in neuronal cells.Fishing for function--distinct roles of Bace1 and Bace2 in Zebrafish development.BACE1 Function and Inhibition: Implications of Intervention in the Amyloid Pathway of Alzheimer's Disease Pathology.Beta-secretase inhibitors in phase I and phase II clinical trials for Alzheimer's disease.β-Secretase BACE1 Promotes Surface Expression and Function of Kv3.4 at Hippocampal Mossy Fiber Synapses.

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BACE1-/- mice exhibit seizure activity that does not correlate with sodium channel level or axonal localization

http://www.wikidata.org/entity/Q30496432

description

2010 nî lūn-bûn

@nan

2010 թուականի Օգոստոսին հրատարակուած գիտական յօդուած

@hyw

2010 թվականի օգոստոսին հրատարակված գիտական հոդված

@hy

2010年の論文

@ja

2010年論文

@yue

2010年論文

@zh-hant

2010年論文

@zh-hk

2010年論文

@zh-mo

2010年論文

@zh-tw

2010年论文

@wuu

name

BACE1-/- mice exhibit seizure ...... l level or axonal localization

@ast

BACE1-/- mice exhibit seizure ...... l level or axonal localization

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type

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BACE1-/- mice exhibit seizure ...... l level or axonal localization

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BACE1-/- mice exhibit seizure ...... l level or axonal localization

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prefLabel

BACE1-/- mice exhibit seizure ...... l level or axonal localization

@ast

BACE1-/- mice exhibit seizure ...... l level or axonal localization

@en

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Molecular Neurodegeneration

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BACE1-/- mice exhibit seizure ...... l level or axonal localization

@en

P2093

Brian D Hitt

http://www.w3.org/2001/XMLSchema#string

Dane M Chetkovich

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Robert Vassar

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Thomas C Jaramillo

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P2860

Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE

Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity

Purification and cloning of amyloid precursor protein beta-secretase from human brain

Sodium channel beta4, a new disulfide-linked auxiliary subunit with similarity to beta2

BACE (beta-secretase) modulates the processing of APLP2 in vivo

De novo mutations in the sodium-channel gene SCN1A cause severe myoclonic epilepsy of infancy

Human aspartic protease memapsin 2 cleaves the beta-secretase site of beta-amyloid precursor protein

From ionic currents to molecular mechanisms: the structure and function of voltage-gated sodium channels

BACE knockout mice are healthy despite lacking the primary beta-secretase activity in brain: implications for Alzheimer's disease therapeutics

A deletion in SCN1B is associated with febrile seizures and early-onset absence epilepsy

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10.1186/1750-1326-5-31

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5

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2010-08-23T00:00:00Z

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2933677

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