Ligand-induced global transitions in the catalytic domain of protein kinase A.
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Many local motions cooperate to produce the adenylate kinase conformational transitionConformational selection in protein binding and functionThe origin of minus-end directionality and mechanochemistry of Ncd motorsMinimum free energy path of ligand-induced transition in adenylate kinaseDynamics connect substrate recognition to catalysis in protein kinase AAllostery in the ferredoxin protein motif does not involve a conformational switchConformational Changes in Inositol 1,3,4,5,6-Pentakisphosphate 2-Kinase upon Substrate Binding: ROLE OF N-TERMINAL LOBE AND ENANTIOMERIC SUBSTRATE PREFERENCEThe CDK9 Tail Determines the Reaction Pathway of Positive Transcription Elongation Factor bMolecular Features of Product Release for the PKA Catalytic CycleStructure, function, and folding of phosphoglycerate kinase are strongly perturbed by macromolecular crowdingHotspot mutations in KIT receptor differentially modulate its allosterically coupled conformational dynamics: impact on activation and drug sensitivityStrain Mediated Adaptation Is Key for Myosin Mechanochemistry: Discovering General Rules for Motor ActivityAdaptability in protein structures: structural dynamics and implications in ligand design.Computational modeling of allosteric communication reveals organizing principles of mutation-induced signaling in ABL and EGFR kinases.Dynamic, structural and thermodynamic basis of insulin-like growth factor 1 kinase allostery mediated by activation loop phosphorylation.Entropic mechanism of large fluctuation in allosteric transition.Conformational Transition Pathways of Epidermal Growth Factor Receptor Kinase Domain from Multiple Molecular Dynamics Simulations and Bayesian Clustering.Prepaying the entropic cost for allosteric regulation in KIXExploration of multi-state conformational dynamics and underlying global functional landscape of maltose binding protein.On the roles of substrate binding and hinge unfolding in conformational changes of adenylate kinase.Understanding the specificity of a docking interaction between JNK1 and the scaffolding protein JIP1.Excited states of ribosome translocation revealed through integrative molecular modeling.Interdomain dynamics and coactivation of the mRNA decapping enzyme Dcp2 are mediated by a gatekeeper tryptophan.A structural perspective on the dynamics of kinesin motors.Dynamic mechanism for the transcription apparatus orchestrating reliable responses to activators.Conformational Selection and Induced Fit Mechanisms in the Binding of an Anticancer Drug to the c-Src KinaseTransitions to catalytically inactive conformations in EGFR kinaseBiomolecular dynamics: order-disorder transitions and energy landscapesSolution NMR Spectroscopy for the Study of Enzyme Allostery.Simulating movement of tRNA through the ribosome during hybrid-state formation.Protein functional landscapes, dynamics, allostery: a tortuous path towards a universal theoretical framework.Allostery and binding cooperativity of the catalytic subunit of protein kinase A by NMR spectroscopy and molecular dynamics simulations.Structural basis of valmerins as dual inhibitors of GSK3β/CDK5.Computationally unraveling how ceritinib overcomes drug-resistance mutations in ALK-rearranged lung cancer.SOP-GPU: influence of solvent-induced hydrodynamic interactions on dynamic structural transitions in protein assembliesSpecificity rendering 'hot-spots' for aurora kinase inhibitor design: the role of non-covalent interactions and conformational transitions.Probing protein multidimensional conformational fluctuations by single-molecule multiparameter photon stamping spectroscopy.Mutation of a kinase allosteric node uncouples dynamics linked to phosphotransfer.Single-molecule patch-clamp FRET microscopy studies of NMDA receptor ion channel dynamics in living cells: revealing the multiple conformational states associated with a channel at its electrical off state.Using computational and mechanical models to study animal locomotion.
P2860
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P2860
Ligand-induced global transitions in the catalytic domain of protein kinase A.
description
2009 nî lūn-bûn
@nan
2009 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
Ligand-induced global transitions in the catalytic domain of protein kinase A.
@ast
Ligand-induced global transitions in the catalytic domain of protein kinase A.
@en
type
label
Ligand-induced global transitions in the catalytic domain of protein kinase A.
@ast
Ligand-induced global transitions in the catalytic domain of protein kinase A.
@en
prefLabel
Ligand-induced global transitions in the catalytic domain of protein kinase A.
@ast
Ligand-induced global transitions in the catalytic domain of protein kinase A.
@en
P2860
P356
P1476
Ligand-induced global transitions in the catalytic domain of protein kinase A.
@en
P2093
Joseph A Adams
Patricia A Jennings
P2860
P304
P356
10.1073/PNAS.0813266106
P407
P577
2009-02-09T00:00:00Z