Filaggrin deficiency confers a paracellular barrier abnormality that reduces inflammatory thresholds to irritants and haptens - Wikidata - wikimedia - TriplyDB

Filaggrin deficiency confers a paracellular barrier abnormality that reduces inflammatory thresholds to irritants and haptens

Filaggrin deficiency confers a paracellular barrier abnormality that reduces inflammatory thresholds to irritants and haptens

http://www.wikidata.org/entity/Q30494794

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Mechanisms of abnormal lamellar body secretion and the dysfunctional skin barrier in patients with atopic dermatitis Mutations in the filaggrin gene and food allergy Filaggrin deficiency promotes the dissemination of cutaneously inoculated vaccinia virus The human epidermal differentiation complex: cornified envelope precursors, S100 proteins and the 'fused genes' family Tmem79/Matt is the matted mouse gene and is a predisposing gene for atopic dermatitis in human subjects Increased retinoic acid levels through ablation of Cyp26b1 determine the processes of embryonic skin barrier formation and peridermal development Re-appraisal of current theories for the development and loss of epidermal pigmentation in hominins and modern humans Skin barrier defects in atopic dermatitis Filaggrin gene mutation c.3321delA is associated with various clinical features of atopic dermatitis in the Chinese Han population.Abnormal skin barrier in the etiopathogenesis of atopic dermatitis.Flaky tail mouse denotes human atopic dermatitis in the steady state and by topical application with Dermatophagoides pteronyssinus extract.Filaggrin-stratified transcriptomic analysis of pediatric skin identifies mechanistic pathways in patients with atopic dermatitis.Sun-induced changes in stratum corneum function are gender and dose dependent in a Chinese population Peanut allergy: effect of environmental peanut exposure in children with filaggrin loss-of-function mutations.Abnormal epidermal barrier recovery in uninvolved skin supports the notion of an epidermal pathogenesis of psoriasis Exacerbation of allergen-induced eczema in TLR4- and TRIF-deficient mice.Atopic dermatitis results in intrinsic barrier and immune abnormalities: implications for contact dermatitis.Filaggrin genotype in ichthyosis vulgaris predicts abnormalities in epidermal structure and function Efficacy of combined peroxisome proliferator-activated receptor-α ligand and glucocorticoid therapy in a murine model of atopic dermatitis.Loss of sirtuin 1 (SIRT1) disrupts skin barrier integrity and sensitizes mice to epicutaneous allergen challenge.Skin reaction and regeneration after single sodium lauryl sulfate exposure stratified by filaggrin genotype and atopic dermatitis phenotype.Topical hesperidin prevents glucocorticoid-induced abnormalities in epidermal barrier function in murine skin.Topical hesperidin improves epidermal permeability barrier function and epidermal differentiation in normal murine skin.Epidermal barrier dysfunction in non-atopic HIV: evidence for an "inside-to-outside" pathogenesis.A topical Chinese herbal mixture improves epidermal permeability barrier function in normal murine skin.SASPase regulates stratum corneum hydration through profilaggrin-to-filaggrin processing.One remarkable molecule: filaggrin.Nrf2 links epidermal barrier function with antioxidant defense Establishing Tolerance to Commensal Skin Bacteria: Timing Is Everything.Increase in short-chain ceramides correlates with an altered lipid organization and decreased barrier function in atopic eczema patients Spontaneous atopic dermatitis is mediated by innate immunity, with the secondary lung inflammation of the atopic march requiring adaptive immunity.Early immune events in the induction of allergic contact dermatitis Comparison of the Efficacy of Atopalm(®) Multi-Lamellar Emulsion Cream and Physiogel(®) Intensive Cream in Improving Epidermal Permeability Barrier in Sensitive Skin Topical apigenin improves epidermal permeability barrier homoeostasis in normal murine skin by divergent mechanisms.Filaggrin inhibits generation of CD1a neolipid antigens by house dust mite-derived phospholipase.Heavy Cigarette Smokers in a Chinese Population Display a Compromised Permeability Barrier Filaggrin-dependent secretion of sphingomyelinase protects against staphylococcal α-toxin-induced keratinocyte death Altered sphingoid base profiles predict compromised membrane structure and permeability in atopic dermatitis Guanine nucleotide exchange factor RABGEF1 regulates keratinocyte-intrinsic signaling to maintain skin homeostasis Impact of atopic dermatitis and loss-of-function mutations in the filaggrin gene on the development of occupational irritant contact dermatitis.

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Filaggrin deficiency confers a paracellular barrier abnormality that reduces inflammatory thresholds to irritants and haptens

http://www.wikidata.org/entity/Q30494794

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2009 nî lūn-bûn

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2009 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած

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2009 թվականի սեպտեմբերին հրատարակված գիտական հոդված

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2009年の論文

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2009年論文

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2009年論文

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J.JACI.2009.06.046

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The Journal of Allergy and Clinical Immunology

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Anna Celli

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P2860

Pathogenesis of permeability barrier abnormalities in the ichthyoses: inherited disorders of lipid metabolism

NHE1 regulates the stratum corneum permeability barrier homeostasis. Microenvironment acidification assessed with fluorescence lifetime imaging

Loss-of-function variations within the filaggrin gene predispose for atopic dermatitis with allergic sensitizations

Common loss-of-function variants of the epidermal barrier protein filaggrin are a major predisposing factor for atopic dermatitis

The aged epidermal permeability barrier. Structural, functional, and lipid biochemical abnormalities in humans and a senescent murine model

Psychological stress downregulates epidermal antimicrobial peptide expression and increases severity of cutaneous infections in mice.

Testing for irritation with a multifactorial approach: comparison of eight non-invasive measuring techniques on five different irritation types.

A highly conserved lysine residue on the head domain of type II keratins is essential for the attachment of keratin intermediate filaments to the cornified cell envelope through isopeptide crosslinking by transglutaminases.

A homozygous frameshift mutation in the mouse Flg gene facilitates enhanced percutaneous allergen priming.

Loss-of-function mutations in the gene encoding filaggrin cause ichthyosis vulgaris.

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