A novel small-molecule inhibitor of protein kinase D blocks pancreatic cancer growth in vitro and in vivo. - Wikidata - wikimedia - TriplyDB

A novel small-molecule inhibitor of protein kinase D blocks pancreatic cancer growth in vitro and in vivo.

A novel small-molecule inhibitor of protein kinase D blocks pancreatic cancer growth in vitro and in vivo.

http://www.wikidata.org/entity/Q30495531

about

Protein kinase D in vascular biology and angiogenesis PKD signaling and pancreatitis Protein Kinase D Enzymes as Regulators of EMT and Cancer Cell Invasion Protein kinase D enzymes: novel kinase targets in pancreatic cancer Mechanistic target of rapamycin (mTOR): a point of convergence in the action of insulin/IGF-1 and G protein-coupled receptor agonists in pancreatic cancer cells Targeting protein kinase C subtypes in pancreatic cancer The Immunogenetics of Autoimmune Cholestasis A KRAS-directed transcriptional silencing pathway that mediates the CpG island methylator phenotype Discovery of diverse small molecule chemotypes with cell-based PKD1 inhibitory activity.A targeted library screen reveals a new inhibitor scaffold for protein kinase D An Evolutionarily Conserved PLC-PKD-TFEB Pathway for Host Defense SD-208, a novel protein kinase D inhibitor, blocks prostate cancer cell proliferation and tumor growth in vivo by inducing G2/M cell cycle arrest Protein kinase D2 induces invasion of pancreatic cancer cells by regulating matrix metalloproteinases.Protein kinase D1 mediates anchorage-dependent and -independent growth of tumor cells via the zinc finger transcription factor Snail1 In vitro cytotoxicity, pharmacokinetics, tissue distribution, and metabolism of small-molecule protein kinase D inhibitors, kb-NB142-70 and kb-NB165-09, in mice bearing human cancer xenografts.Design, Synthesis, and Biological Evaluation of PKD Inhibitors.Investigation of the Role of Protein Kinase D in Human Rhinovirus Replication Protein kinase d as a potential chemotherapeutic target for colorectal cancer.Protein kinase D1 mediates class IIa histone deacetylase phosphorylation and nuclear extrusion in intestinal epithelial cells: role in mitogenic signaling Silencing of protein kinase D2 induces glioma cell senescence via p53-dependent and -independent pathways.Protein kinase D as a potential new target for cancer therapy.Nerve injury induces glial cell line-derived neurotrophic factor (GDNF) expression in Schwann cells through purinergic signaling and the PKC-PKD pathway Role of protein kinase D signaling in pancreatic cancer A novel protein kinase D inhibitor attenuates early events of experimental pancreatitis in isolated rat acini PKD1 mediates negative feedback of PI3K/Akt activation in response to G protein-coupled receptors.Synthesis and Structure-Activity Relationships of Benzothienothiazepinone Inhibitors of Protein Kinase D New pyrazolopyrimidine inhibitors of protein kinase d as potent anticancer agents for prostate cancer cells Protein kinase D: coupling extracellular stimuli to the regulation of cell physiology Protein kinase D signaling: multiple biological functions in health and disease.Spatiotemporally distinct protein kinase D activation in adult cardiomyocytes in response to phenylephrine and endothelin Protein kinase D1 drives pancreatic acinar cell reprogramming and progression to intraepithelial neoplasia Bcr-abl signals to desensitize chronic myeloid leukemia cells to IFNα via accelerating the degradation of its receptor Opposing growth regulatory roles of protein kinase D isoforms in human keratinocytes.Effective Targeting of Estrogen Receptor-Negative Breast Cancers with the Protein Kinase D Inhibitor CRT0066101.Rapid protein kinase D1 signaling promotes migration of intestinal epithelial cells.Functional and therapeutic significance of protein kinase D enzymes in invasive breast cancer.Neurotensin and its high affinity receptor 1 as a potential pharmacological target in cancer therapy GABP transcription factor is required for development of chronic myelogenous leukemia via its control of PRKD2 Positive cross talk between protein kinase D and β-catenin in intestinal epithelial cells: impact on β-catenin nuclear localization and phosphorylation at Ser552 Protein kinase D2 regulates migration and invasion of U87MG glioblastoma cells in vitro

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P2860

A novel small-molecule inhibitor of protein kinase D blocks pancreatic cancer growth in vitro and in vivo.

http://www.wikidata.org/entity/Q30495531

description

2010 nî lūn-bûn

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2010 թուականի Մայիսին հրատարակուած գիտական յօդուած

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2010 թվականի մայիսին հրատարակված գիտական հոդված

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2010年の論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年论文

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name

A novel small-molecule inhibit ...... r growth in vitro and in vivo.

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A novel small-molecule inhibit ...... r growth in vitro and in vivo.

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A novel small-molecule inhibit ...... r growth in vitro and in vivo.

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A novel small-molecule inhibit ...... r growth in vitro and in vivo.

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1535-7163.MCT-09-1145

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Molecular Cancer Therapeutics

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A novel small-molecule inhibit ...... r growth in vitro and in vivo.

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Ajaikumar B Kunnumakkara

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Alexandra Boakes

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Amit Deorukhkar

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Azadeh Bagherzadeh

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Bharat B Aggarwal

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Bokyung Sung

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Caroline Foxton

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Christopher R Ireson

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Dipen Maru

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Enrique Rozengurt

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P2860

Protein kinase D2 mediates lysophosphatidic acid-induced interleukin 8 production in nontransformed human colonic epithelial cells through NF-kappaB

Protein kinase D mediates a stress-induced NF-kappaB activation and survival pathway.

Nuclear factor-kappaB activation: from bench to bedside

Potent and selective disruption of protein kinase D functionality by a benzoxoloazepinolone.

CID755673 enhances mitogenic signaling by phorbol esters, bombesin and EGF through a protein kinase D-independent pathway

Induced overexpression of protein kinase D1 stimulates mitogenic signaling in human pancreatic carcinoma PANC-1 cells

Protein kinase C-dependent protein kinase D activation modulates ERK signal pathway and endothelial cell proliferation by vascular endothelial growth factor

Potential role for protein kinases in regulation of bidirectional endoplasmic reticulum-to-Golgi transport revealed by protein kinase inhibitor H89

Comparative phenotypic studies of duct epithelial cell lines derived from normal human pancreas and pancreatic carcinoma

Protein kinase D signaling.

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1136-1146

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scholarly article

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10.1158/1535-7163.MCT-09-1145

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5

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9

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2010-05-04T00:00:00Z

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44573012

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20442301

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2905628

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