Synthesis and Structure-Activity Relationships of Benzothienothiazepinone Inhibitors of Protein Kinase D
about
Discovery of diverse small molecule chemotypes with cell-based PKD1 inhibitory activity.A targeted library screen reveals a new inhibitor scaffold for protein kinase DSD-208, a novel protein kinase D inhibitor, blocks prostate cancer cell proliferation and tumor growth in vivo by inducing G2/M cell cycle arrestSustained protein kinase D activation mediates respiratory syncytial virus-induced airway barrier disruption.In vitro cytotoxicity, pharmacokinetics, tissue distribution, and metabolism of small-molecule protein kinase D inhibitors, kb-NB142-70 and kb-NB165-09, in mice bearing human cancer xenografts.Design, Synthesis, and Biological Evaluation of PKD Inhibitors.A bifunctional dimethylsulfoxide substitute enhances the aqueous solubility of small organic molecules.New pyrazolopyrimidine inhibitors of protein kinase d as potent anticancer agents for prostate cancer cellsA protein kinase C/protein kinase D pathway protects LNCaP prostate cancer cells from phorbol ester-induced apoptosis by promoting ERK1/2 and NF-{kappa}B activitiesA computational model of PKD and CERT interactions at the trans-Golgi network of mammalian cells.Protein kinase D promotes plasticity-induced F-actin stabilization in dendritic spines and regulates memory formation.Antiproliferative activities of halogenated thieno[3,2-d]pyrimidinesInducible silencing of protein kinase D3 inhibits secretion of tumor-promoting factors in prostate cancer.Protein kinase D signaling in cancer: A friend or foe?The ER-Golgi intermediate compartment is a key membrane source for the LC3 lipidation step of autophagosome biogenesis.An uncharged oxetanyl sulfoxide as a covalent modifier for improving aqueous solubility.PKD1 is a potential biomarker and therapeutic target in triple-negative breast cancer.
P2860
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P2860
Synthesis and Structure-Activity Relationships of Benzothienothiazepinone Inhibitors of Protein Kinase D
description
2011 nî lūn-bûn
@nan
2011 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
Synthesis and Structure-Activi ...... Inhibitors of Protein Kinase D
@ast
Synthesis and Structure-Activi ...... Inhibitors of Protein Kinase D
@en
Synthesis and Structure-Activi ...... Inhibitors of Protein Kinase D
@nl
type
label
Synthesis and Structure-Activi ...... Inhibitors of Protein Kinase D
@ast
Synthesis and Structure-Activi ...... Inhibitors of Protein Kinase D
@en
Synthesis and Structure-Activi ...... Inhibitors of Protein Kinase D
@nl
prefLabel
Synthesis and Structure-Activi ...... Inhibitors of Protein Kinase D
@ast
Synthesis and Structure-Activi ...... Inhibitors of Protein Kinase D
@en
Synthesis and Structure-Activi ...... Inhibitors of Protein Kinase D
@nl
P2093
P2860
P50
P356
P1476
Synthesis and Structure-Activi ...... Inhibitors of Protein Kinase D
@en
P2093
Courtney R Lavalle
Kara M George
Karla Bravo-Altamirano
Manuj Tandon
Marie-Céline Frantz
Q Jane Wang
P2860
P304
P356
10.1021/ML100230N
P577
2011-02-01T00:00:00Z