Phenothiazine-mediated rescue of cognition in tau transgenic mice requires neuroprotection and reduced soluble tau burden. - Wikidata - wikimedia - TriplyDB

Phenothiazine-mediated rescue of cognition in tau transgenic mice requires neuroprotection and reduced soluble tau burden.

Phenothiazine-mediated rescue of cognition in tau transgenic mice requires neuroprotection and reduced soluble tau burden.

http://www.wikidata.org/entity/Q30497435

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Tau-Centric Targets and Drugs in Clinical Development for the Treatment of Alzheimer's Disease The ubiquitin proteasomal system: a potential target for the management of Alzheimer's disease The Metamorphic Nature of the Tau Protein: Dynamic Flexibility Comes at a Cost Chaperones in Neurodegeneration Mouse models of frontotemporal dementia The role of tau in neurodegenerative diseases and its potential as a therapeutic target Abnormal cognition, sleep, EEG and brain metabolism in a novel knock-in Alzheimer mouse, PLB1 The human HSP70 family of chaperones: where do we stand?Modulating self-assembly of amyloidogenic proteins as a therapeutic approach for neurodegenerative diseases: strategies and mechanisms Allostery in the Hsp70 chaperone proteins Curcumin suppresses soluble tau dimers and corrects molecular chaperone, synaptic, and behavioral deficits in aged human tau transgenic mice Lack of effect of methylene blue in the SOD1 G93A mouse model of amyotrophic lateral sclerosis Intrinsic Tau Acetylation Is Coupled to Auto-Proteolytic Tau Fragmentation Attenuation of noise-induced hearing loss using methylene blue.Histone deacetylase 6 inhibition improves memory and reduces total tau levels in a mouse model of tau deposition.Severe amygdala dysfunction in a MAPT transgenic mouse model of frontotemporal dementia Preventive methylene blue treatment preserves cognition in mice expressing full-length pro-aggregant human Tau.Reducing tau aggregates with anle138b delays disease progression in a mouse model of tauopathies Methylene blue upregulates Nrf2/ARE genes and prevents tau-related neurotoxicity Human cyclophilin 40 unravels neurotoxic amyloids.An aggregation sensing reporter identifies leflunomide and teriflunomide as polyglutamine aggregate inhibitors.Motor and cognitive deficits in aged tau knockout mice in two background strains.Effect size of memory deficits in mice with adult-onset P301L tau expression.The hunt for gene effects pertinent to behavioral traits and psychiatric disorders: from mouse to human.Methylene blue as a cerebral metabolic and hemodynamic enhancer.Heat shock protein 70 in Alzheimer's disease PE859, a novel tau aggregation inhibitor, reduces aggregated tau and prevents onset and progression of neural dysfunction in vivo.Promoting autophagic clearance: viable therapeutic targets in Alzheimer's disease.Tau reduction prevents disease in a mouse model of Dravet syndrome The toxicity of tau in Alzheimer disease: turnover, targets and potential therapeutics Tolfenamic acid reduces tau and CDK5 levels: implications for dementia and tauopathies.Molecular chaperones and regulation of tau quality control: strategies for drug discovery in tauopathies.Advances in tau-based drug discovery.The earliest tau dysfunction in Alzheimer's disease? Tau phosphorylated at s422 as a toxic seed Synthesis, stereochemical analysis, and derivatization of myricanol provide new probes that promote autophagic tau clearance.Effects of oxidized and reduced forms of methylthioninium in two transgenic mouse tauopathy models.Nontoxic singlet oxygen generator as a therapeutic candidate for treating tauopathies.Effects of post-session administration of methylene blue on fear extinction and contextual memory in adults with claustrophobia.The many faces of tau DnaJA1 antagonizes constitutive Hsp70-mediated stabilization of tau.

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Phenothiazine-mediated rescue of cognition in tau transgenic mice requires neuroprotection and reduced soluble tau burden.

http://www.wikidata.org/entity/Q30497435

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2010 nî lūn-bûn

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2010 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած

@hyw

2010 թվականի նոյեմբերին հրատարակված գիտական հոդված

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2010年の論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年论文

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Phenothiazine-mediated rescue ...... nd reduced soluble tau burden.

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Phenothiazine-mediated rescue ...... nd reduced soluble tau burden.

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Phenothiazine-mediated rescue ...... nd reduced soluble tau burden.

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Phenothiazine-mediated rescue ...... nd reduced soluble tau burden.

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Phenothiazine-mediated rescue ...... nd reduced soluble tau burden.

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Phenothiazine-mediated rescue ...... nd reduced soluble tau burden.

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Molecular Neurodegeneration

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Phenothiazine-mediated rescue ...... nd reduced soluble tau burden.

@en

P2093

Amelia G Johnson

http://www.w3.org/2001/XMLSchema#string

Chad A Dickey

http://www.w3.org/2001/XMLSchema#string

Clara Kraft

http://www.w3.org/2001/XMLSchema#string

Edwin J Weeber

http://www.w3.org/2001/XMLSchema#string

Erin E Congdon

http://www.w3.org/2001/XMLSchema#string

Jason E Gestwicki

http://www.w3.org/2001/XMLSchema#string

Jeffrey R Jones

http://www.w3.org/2001/XMLSchema#string

John C O'Leary

http://www.w3.org/2001/XMLSchema#string

John Koren

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Jose F Abisambra

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P2860

Methylene blue reduces aβ levels and rescues early cognitive deficit by increasing proteasome activity

Tau suppression in a neurodegenerative mouse model improves memory function

Unbiased stereological estimation of the total number of neurons in thesubdivisions of the rat hippocampus using the optical fractionator

Microtubule-binding drugs offset tau sequestration by stabilizing microtubules and reversing fast axonal transport deficits in a tauopathy model

Therapeutic standards in Alzheimer disease.

Inhibition of heparin-induced tau filament formation by phenothiazines, polyphenols, and porphyrins.

Phenothiazine molecule provides the basic chemical structure for various classes of pharmacotherapeutic agents.

Methylthioninium chloride reverses cognitive deficits induced by scopolamine: comparison with rivastigmine.

Caspase activation precedes and leads to tangles.

The high-affinity HSP90-CHIP complex recognizes and selectively degrades phosphorylated tau client proteins.

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45

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10.1186/1750-1326-5-45

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5

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2010-11-01T00:00:00Z

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47643870

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1032394912

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21040568

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2989315

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