The novel pyrrolidine nor-lobelane analog UKCP-110 [cis-2,5-di-(2-phenethyl)-pyrrolidine hydrochloride] inhibits VMAT2 function, methamphetamine-evoked dopamine release, and methamphetamine self-administration in rats.
about
VMAT2: a dynamic regulator of brain monoaminergic neuronal function interacting with drugs of abusemeso-Transdiene analogs inhibit vesicular monoamine transporter-2 function and methamphetamine-evoked dopamine releaseThe vesicular monoamine transporter-2: an important pharmacological target for the discovery of novel therapeutics to treat methamphetamine abuse.Novel N-1,2-dihydroxypropyl analogs of lobelane inhibit vesicular monoamine transporter-2 function and methamphetamine-evoked dopamine release.Vesicular monoamine transporter 2 and the acute and long-term response to 3,4-(±)-methylenedioxymethamphetamine.The effect of a novel VMAT2 inhibitor, GZ-793A, on methamphetamine reward in rats.Trace Amine-Associated Receptor 1 Regulation of Methamphetamine Intake and Related Traits.Preclinical Efficacy of Novel Vesicular Monoamine Transporter 2 Inhibitors as Antagonists of d-Methamphetamine Self-Administration in Rats.Importance of Substrate-Coupled Proton Antiport by the Vesicular Monoamine Transporter in the Actions of Amphetamines in Drosophila Brain.Synthesis and evaluation of novel azetidine analogs as potent inhibitors of vesicular [3H]dopamine uptake.Solvent-free double aza-Michael under ultrasound irradiation: diastereoselective sequential one-pot synthesis of pyrrolidine Lobelia alkaloids analogues.
P2860
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P2860
The novel pyrrolidine nor-lobelane analog UKCP-110 [cis-2,5-di-(2-phenethyl)-pyrrolidine hydrochloride] inhibits VMAT2 function, methamphetamine-evoked dopamine release, and methamphetamine self-administration in rats.
description
2010 nî lūn-bûn
@nan
2010 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
The novel pyrrolidine nor-lobe ...... e self-administration in rats.
@ast
The novel pyrrolidine nor-lobe ...... e self-administration in rats.
@en
type
label
The novel pyrrolidine nor-lobe ...... e self-administration in rats.
@ast
The novel pyrrolidine nor-lobe ...... e self-administration in rats.
@en
prefLabel
The novel pyrrolidine nor-lobe ...... e self-administration in rats.
@ast
The novel pyrrolidine nor-lobe ...... e self-administration in rats.
@en
P2093
P2860
P356
P1476
The novel pyrrolidine nor-lobe ...... e self-administration in rats.
@en
P2093
Ashish Vartak
David B Horton
Emily D Denehy
Joshua S Beckmann
Justin R Nickell
Kiran B Siripurapu
Linda P Dwoskin
Michael T Bardo
Peter A Crooks
P2860
P304
P356
10.1124/JPET.110.172742
P407
P577
2010-08-30T00:00:00Z