Pyrrolidine analogues of lobelane: relationship of affinity for the dihydrotetrabenazine binding site with function of the vesicular monoamine transporter 2 (VMAT2).
about
The novel pyrrolidine nor-lobelane analog UKCP-110 [cis-2,5-di-(2-phenethyl)-pyrrolidine hydrochloride] inhibits VMAT2 function, methamphetamine-evoked dopamine release, and methamphetamine self-administration in rats.Design, synthesis and interaction at the vesicular monoamine transporter-2 of lobeline analogs: potential pharmacotherapies for the treatment of psychostimulant abuse.Synthesis and in vitro evaluation of water-soluble 1,4-diphenethylpiperazine analogs as novel inhibitors of the vesicular monoamine transporter-2Quinlobelane: a water-soluble lobelane analogue and inhibitor of VMAT2Synthesis of Lobeline, Lobelane and their Analogues. A Review.Synthesis and evaluation of novel azetidine analogs as potent inhibitors of vesicular [3H]dopamine uptake.Exploring the effect of N-substitution in nor-lobelane on the interaction with VMAT2: discovery of a potential clinical candidate for treatment of methamphetamine abuse.cis-2,5-Bis(2-fluoro-5-meth-oxy-pheneth-yl)pyrrolidinium formate.Lobelane analogues containing 4-hydroxy and 4-(2-fluoroethoxy) aromatic substituents: Potent and selective inhibitors of [(3)H]dopamine uptake at the vesicular monoamine transporter-2.Quinolyl analogues of norlobelane: novel potent inhibitors of [(3)H]dihydrotetrabenazine binding and [(3)H]dopamine uptake at the vesicular monoamine transporter-2.Pyrrolidine analogs of GZ-793A: synthesis and evaluation as inhibitors of the vesicular monoamine transporter-2 (VMAT2).Iterative direct C(sp3)-H functionalization of amines: diastereoselective divergent syntheses of α,α'-disubstituted alicyclic amines.Solvent-free double aza-Michael under ultrasound irradiation: diastereoselective sequential one-pot synthesis of pyrrolidine Lobelia alkaloids analogues.
P2860
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P2860
Pyrrolidine analogues of lobelane: relationship of affinity for the dihydrotetrabenazine binding site with function of the vesicular monoamine transporter 2 (VMAT2).
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on December 2009
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Pyrrolidine analogues of lobel ...... noamine transporter 2 (VMAT2).
@en
Pyrrolidine analogues of lobel ...... icular monoamine transporter 2
@nl
type
label
Pyrrolidine analogues of lobel ...... noamine transporter 2 (VMAT2).
@en
Pyrrolidine analogues of lobel ...... icular monoamine transporter 2
@nl
prefLabel
Pyrrolidine analogues of lobel ...... noamine transporter 2 (VMAT2).
@en
Pyrrolidine analogues of lobel ...... icular monoamine transporter 2
@nl
P2093
P2860
P356
P1476
Pyrrolidine analogues of lobel ...... noamine transporter 2 (VMAT2).
@en
P2093
Ashish P Vartak
Jaturaporn Chagkutip
Justin R Nickell
Linda P Dwoskin
Peter A Crooks
P2860
P304
P356
10.1021/JM900770H
P407
P577
2009-12-01T00:00:00Z