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Alzheimer disease models and human neuropathology: similarities and differences

Alzheimer disease models and human neuropathology: similarities and differences

http://www.wikidata.org/entity/Q30499574

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Transthyretin and the brain re-visited: is neuronal synthesis of transthyretin protective in Alzheimer's disease?Altered longevity-assurance activity of p53:p44 in the mouse causes memory loss, neurodegeneration and premature death Drug Development in Alzheimer's Disease: The Contribution of PET and SPECT Mechanical Stress as the Common Denominator between Chronic Inflammation, Cancer, and Alzheimer's Disease Elusive roles for reactive astrocytes in neurodegenerative diseases Rodent models of neuroinflammation for Alzheimer's disease Endogenous murine Aβ increases amyloid deposition in APP23 but not in APPPS1 transgenic mice.Cerebral β-Amyloidosis in Mice Investigated by Ultramicroscopy High-throughput 3D whole-brain quantitative histopathology in rodents.Tau Biology and Tau-Directed Therapies for Alzheimer's Disease Genetic variants associated with neurodegenerative Alzheimer disease in natural models Deletion of the alpha 7 nicotinic acetylcholine receptor gene improves cognitive deficits and synaptic pathology in a mouse model of Alzheimer's disease ApoB100/LDLR-/- hypercholesterolaemic mice as a model for mild cognitive impairment and neuronal damage The Psen1-L166P-knock-in mutation leads to amyloid deposition in human wild-type amyloid precursor protein YAC transgenic mice.APP transgenic mice for modelling behavioural and psychological symptoms of dementia (BPSD).COL25A1 triggers and promotes Alzheimer's disease-like pathology in vivo.Mechanism of amyloid plaque formation suggests an intracellular basis of Abeta pathogenicity.Co-occurrence of Alzheimer's disease ß-amyloid and τ pathologies at synapses.Synaptic deficits in layer 5 neurons precede overt structural decay in 5xFAD mice.Increasing membrane cholesterol of neurons in culture recapitulates Alzheimer's disease early phenotypes.The Use of Neuroimaging to Assess Associations Among Diet, Nutrients, Metabolic Syndrome, and Alzheimer's Disease.Genetically modified pig models for neurodegenerative disorders.Cognitive impairment in the Tg6590 transgenic rat model of Alzheimer's disease Changes in the expression of genes associated with intraneuronal amyloid-beta and tau in Alzheimer's disease.Dendritic vulnerability in neurodegenerative disease: insights from analyses of cortical pyramidal neurons in transgenic mouse models [Neuroimaging in Alzheimer's disease: a synthesis and a contribution to the understanding of physiopathological mechanisms].Accumulation of intraneuronal Abeta correlates with ApoE4 genotype Comparison of New Tau PET-Tracer Candidates With [18F]T808 and [18F]T807 The expression of apoptosis inducing factor (AIF) is associated with aging-related cell death in the cortex but not in the hippocampus in the TgCRND8 mouse model of Alzheimer's disease.Transgenic autoinhibition of p21-activated kinase exacerbates synaptic impairments and fronto-dependent behavioral deficits in an animal model of Alzheimer's disease.Olfactory and visuospatial learning and memory performance in two strains of Alzheimer's disease model mice--a longitudinal study In vivo characterization of a bigenic fluorescent mouse model of Alzheimer's disease with neurodegeneration Neuron loss in transgenic mouse models of Alzheimer's disease Determination of odor detection threshold in the Gottingen minipig.Spine pruning in 5xFAD mice starts on basal dendrites of layer 5 pyramidal neurons Gene-environment interaction research and transgenic mouse models of Alzheimer's disease.Probing the biology of Alzheimer's disease in mice.Protein tau: prime cause of synaptic and neuronal degeneration in Alzheimer's disease.Versatile somatic gene transfer for modeling neurodegenerative diseases.In vivo detection of amyloid-β deposits using heavy chain antibody fragments in a transgenic mouse model for Alzheimer's disease

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Alzheimer disease models and human neuropathology: similarities and differences

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2007 nî lūn-bûn

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Alzheimer disease models and human neuropathology: similarities and differences

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Alzheimer disease models and human neuropathology: similarities and differences

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Alzheimer disease models and human neuropathology: similarities and differences

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Alzheimer disease models and human neuropathology: similarities and differences

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Alzheimer disease models and human neuropathology: similarities and differences

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Acta Neuropathologica

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Alzheimer disease models and human neuropathology: similarities and differences

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Benoît Delatour

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Charles Duyckaerts

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P2860

Persistent amyloidosis following suppression of Abeta production in a transgenic model of Alzheimer disease

A Oligomer-Induced Aberrations in Synapse Composition, Shape, and Density Provide a Molecular Basis for Loss of Connectivity in Alzheimer's Disease

Correlative Memory Deficits, Abeta Elevation, and Amyloid Plaques in Transgenic Mice

Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease

Cloning and sequencing of the cDNA encoding an isoform of microtubule-associated protein tau containing four tandem repeats: differential expression of tau protein mRNAs in human brain

Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease

Amyloid plaque core protein in Alzheimer disease and Down syndrome

Hippocampal neuron loss exceeds amyloid plaque load in a transgenic mouse model of Alzheimer's disease

Focal glial activation coincides with increased BACE1 activation and precedes amyloid plaque deposition in APP[V717I] transgenic mice.

Neuropathological stageing of Alzheimer-related changes

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1

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Marie-Claude Potier

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Alzheimer's disease

biomedical investigative technique

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2100431

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