about
Comparative genomics of the apicomplexan parasites Toxoplasma gondii and Neospora caninum: Coccidia differing in host range and transmission strategyDeath and resurrection of the human IRGM geneA dedicated promoter drives constitutive expression of the cell-autonomous immune resistance GTPase, Irga6 (IIGP1) in mouse liverDisruption of the Toxoplasma gondii parasitophorous vacuole by IFNgamma-inducible immunity-related GTPases (IRG proteins) triggers necrotic cell deathLocalisation and mislocalisation of the interferon-inducible immunity-related GTPase, Irgm1 (LRG-47) in mouse cellsDisruption of Toxoplasma gondii parasitophorous vacuoles by the mouse p47-resistance GTPases.The activation mechanism of Irga6, an interferon-inducible GTPase contributing to mouse resistance against Toxoplasma gondiiThe impact of Toxoplasma gondii on the mammalian genomeUNC93B1 mediates host resistance to infection with Toxoplasma gondiiIdentification of the microsporidian Encephalitozoon cuniculi as a new target of the IFNγ-inducible IRG resistance systemRegulatory interactions between IRG resistance GTPases in the cellular response to Toxoplasma gondiiInactive and active states of the interferon-inducible resistance GTPase, Irga6, in vivoCellular responses to interferon-gammaModeling infectious disease in mice: co-adaptation and the role of host-specific IFNgamma responses.The mouse resistance protein Irgm1 (LRG-47): a regulator or an effector of pathogen defense?Spontaneous focal activation of invariant natural killer T (iNKT) cells in mouse liver and kidney.Virulent Toxoplasma gondii evade immunity-related GTPase-mediated parasite vacuole disruption within primed macrophages.The IFN-γ-inducible GTPase, Irga6, protects mice against Toxoplasma gondii but not against Plasmodium berghei and some other intracellular pathogens.The immunity-related GTPase Irga6 dimerizes in a parallel head-to-head fashionRabGDIα is a negative regulator of interferon-γ-inducible GTPase-dependent cell-autonomous immunity to Toxoplasma gondiiLoss of the interferon-γ-inducible regulatory immunity-related GTPase (IRG), Irgm1, causes activation of effector IRG proteins on lysosomes, damaging lysosomal function and predicting the dramatic susceptibility of Irgm1-deficient mice to infection.The immunity-related GTPases in mammals: a fast-evolving cell-autonomous resistance system against intracellular pathogens.Restrictions on the use of antigenic peptides by the immune systemIdentification of marrow-derived and thymus-derived small lymphocytes in the lymphoid tissue and thoracic duct lymph of normal rats.Tumorigenicity conferred to lymphoma mutant by major histocompatibility complex-encoded transporter gene.Immunoglobulin heavy chain locus of the rat: striking homology to mouse antibody genes.The interferon-inducible GTPases.The arginine-rich N-terminal domain of ROP18 is necessary for vacuole targeting and virulence of Toxoplasma gondii.The IRG proteins: a function in search of a mechanism.Balance of Irgm protein activities determines IFN-gamma-induced host defenseWhy didn't Darwin discover Mendel's laws?The Toxoplasma gondii rhoptry protein ROP18 is an Irga6-specific kinase and regulated by the dense granule protein GRA7.Concerted evolution of class I genes in the major histocompatibility complex of murine rodents.Innate resistance against Toxoplasma gondii: an evolutionary tale of mice, cats, and men.The IRG protein-based resistance mechanism in mice and its relation to virulence in Toxoplasma gondii.Immunity-related GTPase M (IRGM) proteins influence the localization of guanylate-binding protein 2 (GBP2) by modulating macroautophagy.Differential inductions of TNF-alpha and IGTP, IIGP by structurally diverse classic and non-classic lipopolysaccharides.Specific positive selection of lymphocytes reactive to strong histocompatibility antigens.Immunological help at last.Brucella abortus induces Irgm3 and Irga6 expression via type-I IFN by a MyD88-dependent pathway, without the requirement of TLR2, TLR4, TLR5 and TLR9.
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Jonathan C Howard
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Jonathan C Howard
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Jonathan C. Howard
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Jonathan C. Howard
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Jonathan Howard
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Jonathan C Howard
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Jonathan C. Howard
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Jonathan C Howard
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Jonathan C Howard
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Jonathan C. Howard
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Jonathan Howard
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جوناثان سي. هوارد
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P106
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55976881000
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0000-0003-2756-5143