Immunity-related GTPase M (IRGM) proteins influence the localization of guanylate-binding protein 2 (GBP2) by modulating macroautophagy. - Wikidata - wikimedia - TriplyDB

Immunity-related GTPase M (IRGM) proteins influence the localization of guanylate-binding protein 2 (GBP2) by modulating macroautophagy.

Immunity-related GTPase M (IRGM) proteins influence the localization of guanylate-binding protein 2 (GBP2) by modulating macroautophagy.

http://www.wikidata.org/entity/Q38263938

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The polymorphic pseudokinase ROP5 controls virulence in Toxoplasma gondii by regulating the active kinase ROP18 Cell death of gamma interferon-stimulated human fibroblasts upon Toxoplasma gondii infection induces early parasite egress and limits parasite replication The E2-like conjugation enzyme Atg3 promotes binding of IRG and Gbp proteins to Chlamydia- and Toxoplasma-containing vacuoles and host resistance.Interferon-inducible effector mechanisms in cell-autonomous immunity.Caspase-11 activation requires lysis of pathogen-containing vacuoles by IFN-induced GTPases.Guanylate-binding protein 1 (Gbp1) contributes to cell-autonomous immunity against Toxoplasma gondii.IRG and GBP host resistance factors target aberrant, "non-self" vacuoles characterized by the missing of "self" IRGM proteins Mammalian target of Rapamycin inhibition and mycobacterial survival are uncoupled in murine macrophages.Palmitoylation of the immunity related GTPase, Irgm1: impact on membrane localization and ability to promote mitochondrial fission Autophagy as an innate immunity paradigm: expanding the scope and repertoire of pattern recognition receptors.Loss of the interferon-γ-inducible regulatory immunity-related GTPase (IRG), Irgm1, causes activation of effector IRG proteins on lysosomes, damaging lysosomal function and predicting the dramatic susceptibility of Irgm1-deficient mice to infection.A Noncanonical Autophagy Pathway Restricts Toxoplasma gondii Growth in a Strain-Specific Manner in IFN-γ-Activated Human Cells.Ubiquitin systems mark pathogen-containing vacuoles as targets for host defense by guanylate binding proteins IFN-inducible GTPases in host cell defense Bioinformatics analysis of hepatitis C virus genotype 2a-induced human hepatocellular carcinoma in Huh7 cells.Irgm1-deficient mice exhibit Paneth cell abnormalities and increased susceptibility to acute intestinal inflammation.Chlamydia trachomatis Is Resistant to Inclusion Ubiquitination and Associated Host Defense in Gamma Interferon-Primed Human Epithelial Cells.Galectin-3 directs antimicrobial guanylate binding proteins to vacuoles furnished with bacterial secretion systems.Sensing the enemy, containing the threat: cell-autonomous immunity to Chlamydia trachomatis.Ubiquitination of pathogen-containing vacuoles promotes host defense to Chlamydia trachomatis and Toxoplasma gondii.Autophagy as an innate defense against mycobacteria.Interferon-inducible guanylate binding protein (GBP2) is associated with better prognosis in breast cancer and indicates an efficient T cell response.Interferon-Inducible GTPases in Host Resistance, Inflammation and Disease.Interferon-γ in Salmonella pathogenesis: New tricks for an old dog.Inhibition of apoptosis by Rv2456c through Nuclear factor-κB extends the survival of Mycobacterium tuberculosis.Quo vadis? Interferon-inducible GTPases go to their target membranes via the LC3-conjugation system of autophagy.Metabolic Alterations Contribute to Enhanced Inflammatory Cytokine Production in Irgm1-deficient Macrophages.Interferon-inducible GTPase: a novel viral response protein involved in rabies virus infection.Irgm1 coordinately regulates autoimmunity and host defense at select mucosal surfaces.Mutagenic primer-based PCR-RFLP assay for genotyping IRGM gene promoter variant rs4958843 (C/T).Mechanisms of interferon-beta-induced inhibition of Toxoplasma gondii growth in murine macrophages and embryonic fibroblasts: role of immunity-related GTPase M1.Murine Gbp1 and Gbp2 are ubiquitinated independent of Toxoplasma gondii infection.Lipid Droplet, a Key Player in Host-Parasite Interactions.The Diurnal Timing of Starvation Differently Impacts Murine Hepatic Gene Expression and Lipid Metabolism - A Systems Biology Analysis Using Self-Organizing Maps

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P2860

Immunity-related GTPase M (IRGM) proteins influence the localization of guanylate-binding protein 2 (GBP2) by modulating macroautophagy.

http://www.wikidata.org/entity/Q38263938

description

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Immunity-related GTPase M (IRG ...... by modulating macroautophagy.

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Immunity-related GTPase M (IRG ...... by modulating macroautophagy.

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Immunity-related GTPase M (IRG ...... by modulating macroautophagy.

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Journal of Biological Chemistry

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Immunity-related GTPase M (IRG ...... by modulating macroautophagy.

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Gregory A Taylor

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Julia P Hunn

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Jörn Coers

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Maria K Traver

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Sandra Beer

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Stanley C Henry

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Tim Oliver

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Viviana Cantillana

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P2860

The interferon-inducible p47 (IRG) GTPases in vertebrates: loss of the cell autonomous resistance mechanism in the human lineage.

Disruption of Toxoplasma gondii parasitophorous vacuoles by the mouse p47-resistance GTPases.

Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes

PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1

Homeostatic levels of p62 control cytoplasmic inclusion body formation in autophagy-deficient mice

p62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy

Mammalian autophagy: core molecular machinery and signaling regulation

Coordinated loading of IRG resistance GTPases on to the Toxoplasma gondii parasitophorous vacuole

cPLA2 regulates the expression of type I interferons and intracellular immunity to Chlamydia trachomatis

Dissection of autophagosome formation using Apg5-deficient mouse embryonic stem cells

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30471-30480

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10.1074/JBC.M111.251967

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35

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286

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Jonathan C. Howard

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