about
BRCA1 promoter methylation in peripheral blood DNA of mutation negative familial breast cancer patients with a BRCA1 tumour phenotypeHigh resolution melting for mutation scanning of TP53 exons 5-8A critical re-assessment of DNA repair gene promoter methylation in non-small cell lung carcinomaCharacterization of a KRAB family zinc finger gene, ZNF195, mapping to chromosome band 11p15.5Sensitive Melting Analysis after Real Time- Methylation Specific PCR (SMART-MSP): high-throughput and probe-free quantitative DNA methylation detectionMethylation-sensitive high resolution melting (MS-HRM): a new approach for sensitive and high-throughput assessment of methylationOptimisation of the RT-PCR detection of immunomagnetically enriched carcinoma cellsFusion of the NUP98 gene with the LEDGF/p52 gene defines a recurrent acute myeloid leukemia translocationA novel duplication polymorphism in the FANCA promoter and its association with breast and ovarian cancerLoss of CDKN2A expression is a frequent event in primary invasive melanoma and correlates with sensitivity to the CDK4/6 inhibitor PD0332991 in melanoma cell lines.Appraisal of the technologies and review of the genomic landscape of ductal carcinoma in situ of the breastMethylation-sensitive, single-strand conformation analysis (MS-SSCA): A rapid method to screen for and analyze methylationThe implications of heterogeneous DNA methylation for the accurate quantification of methylationWnt inhibitory factor 1 is epigenetically silenced in human osteosarcoma, and targeted disruption accelerates osteosarcomagenesis in miceExemplary multiplex bisulfite amplicon data used to demonstrate the utility of Methpat.High resolution melting analysis for the rapid and sensitive detection of mutations in clinical samples: KRAS codon 12 and 13 mutations in non-small cell lung cancer.Negative selection of chronic lymphocytic leukaemia cells using a bifunctional rosette-based antibody cocktailRapid detection of carriers with BRCA1 and BRCA2 mutations using high resolution melting analysis.High resolution melting analysis for rapid and sensitive EGFR and KRAS mutation detection in formalin fixed paraffin embedded biopsies.Detection of the transforming AKT1 mutation E17K in non-small cell lung cancer by high resolution melting.A new approach to primer design for the control of PCR bias in methylation studies.DNA methylation of the ABO promoter underlies loss of ABO allelic expression in a significant proportion of leukemic patients.Validation of a primer optimisation matrix to improve the performance of reverse transcription - quantitative real-time PCR assaysNo evidence for promoter region methylation of the succinate dehydrogenase and fumarate hydratase tumour suppressor genes in breast cancer.Constitutional methylation of the BRCA1 promoter is specifically associated with BRCA1 mutation-associated pathology in early-onset breast cancer.Mapping of actionable mutations to histological subtype domains in lung adenocarcinoma: implications for precision medicine.A multiplex endpoint RT-PCR assay for quality assessment of RNA extracted from formalin-fixed paraffin-embedded tissues.Clinical responses observed with imatinib or sorafenib in melanoma patients expressing mutations in KITInvestigating the potential role of genetic and epigenetic variation of DNA methyltransferase genes in hyperplastic polyposis syndromeIntegrated mutation, copy number and expression profiling in resectable non-small cell lung cancer.A high-throughput protocol for mutation scanning of the BRCA1 and BRCA2 genes.HER3 and downstream pathways are involved in colonization of brain metastases from breast cancerLocalization of the human growth arrest-specific gene (GAS1) to chromosome bands 9q21.3-q22, a region frequently deleted in myeloid malignancies.Prevalence and natural history of ALK positive non-small-cell lung cancer and the clinical impact of targeted therapy with ALK inhibitorsMutational profiling of familial male breast cancers reveals similarities with luminal A female breast cancer with rare TP53 mutations.Quantitative threefold allele-specific PCR (QuanTAS-PCR) for highly sensitive JAK2 V617F mutant allele detection.Methylation profiling of ductal carcinoma in situ and its relationship to histopathological features.Assessing combined methylation-sensitive high resolution melting and pyrosequencing for the analysis of heterogeneous DNA methylationIntratumoral genetic heterogeneity in metastatic melanoma is accompanied by variation in malignant behaviors.The expression of the ubiquitin ligase SIAH2 (seven in absentia homolog 2) is mediated through gene copy number in breast cancer and is associated with a basal-like phenotype and p53 expression
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P50
description
hulumtues
@sq
onderzoeker
@nl
researcher
@en
հետազոտող
@hy
name
Alexander Dobrovic
@ast
Alexander Dobrovic
@en
Alexander Dobrovic
@es
Alexander Dobrovic
@fr
Alexander Dobrovic
@nl
Alexander Dobrovic
@pt
Alexander Dobrovic
@sl
type
label
Alexander Dobrovic
@ast
Alexander Dobrovic
@en
Alexander Dobrovic
@es
Alexander Dobrovic
@fr
Alexander Dobrovic
@nl
Alexander Dobrovic
@pt
Alexander Dobrovic
@sl
prefLabel
Alexander Dobrovic
@ast
Alexander Dobrovic
@en
Alexander Dobrovic
@es
Alexander Dobrovic
@fr
Alexander Dobrovic
@nl
Alexander Dobrovic
@pt
Alexander Dobrovic
@sl
P106
P21
P31
P496
0000-0003-3414-112X