Ganglioside GM1 induces phosphorylation of mutant huntingtin and restores normal motor behavior in Huntington disease mice - Wikidata - wikimedia - TriplyDB

Ganglioside GM1 induces phosphorylation of mutant huntingtin and restores normal motor behavior in Huntington disease mice

Ganglioside GM1 induces phosphorylation of mutant huntingtin and restores normal motor behavior in Huntington disease mice

http://www.wikidata.org/entity/Q30506469

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Ablation of neuronal ceramide synthase 1 in mice decreases ganglioside levels and expression of myelin-associated glycoprotein in oligodendrocytes Mouse models of polyglutamine diseases in therapeutic approaches: review and data table. Part II.Fingolimod for the treatment of neurological diseases-state of play and future perspectives Glycosphingolipid-Protein Interaction in Signal Transduction Serine 421 regulates mutant huntingtin toxicity and clearance in mice.Deletion of the huntingtin proline-rich region does not significantly affect normal huntingtin function in mice Biophysical insights into how surfaces, including lipid membranes, modulate protein aggregation related to neurodegeneration.Defective Sphingosine-1-phosphate metabolism is a druggable target in Huntington's disease.Inhibition of lipid signaling enzyme diacylglycerol kinase epsilon attenuates mutant huntingtin toxicity.Targets for future clinical trials in Huntington's disease: what's in the pipeline?Therapeutic advances in Huntington's Disease.Phosphorylation of mutant huntingtin at serine 116 modulates neuronal toxicity.Differential Anatomical Expression of Ganglioside GM1 Species Containing d18:1 or d20:1 Sphingosine Detected by MALDI Imaging Mass Spectrometry in Mature Rat Brain.Integration-independent Transgenic Huntington Disease Fragment Mouse Models Reveal Distinct Phenotypes and Life Span in Vivo.The emerging role of the first 17 amino acids of huntingtin in Huntington's disease Selective histone deacetylase (HDAC) inhibition imparts beneficial effects in Huntington's disease mice: implications for the ubiquitin-proteasomal and autophagy systems.Common disease signatures from gene expression analysis in Huntington's disease human blood and brain A flexible polyglutamine hinge opens new doors for understanding huntingtin function Polyglutamine domain flexibility mediates the proximity between flanking sequences in huntingtin Genetic manipulations of mutant huntingtin in mice: new insights into Huntington's disease pathogenesis.Promise and Pitfalls of Mitochondrial Replacement for Prevention and Cure of Heritable Neurodegenerative Diseases Caused by Deleterious Mutations in Mitochondrial DNA Antidepressant-Like Effects of GM1 Ganglioside Involving the BDNF Signaling Cascade in Mice.Sphingolipids and brain resident macrophages in neuroinflammation: an emerging aspect of nervous system pathology.Pathogenic role of ganglioside metabolism in neurodegenerative diseases.Pridopidine, a dopamine stabilizer, improves motor performance and shows neuroprotective effects in Huntington disease R6/2 mouse model.Nuclear Lipids in the Nervous System: What they do in Health and Disease.FTY720 (fingolimod) is a neuroprotective and disease-modifying agent in cellular and mouse models of Huntington disease.Proteins Containing Expanded Polyglutamine Tracts and Neurodegenerative Disease.A multifunctional, multi-pathway intracellular localization signal in Huntingtin.Polyglutamine expansion affects huntingtin conformation in multiple Huntington's disease models.The huntingtin N17 domain is a multifunctional CRM1 and Ran-dependent nuclear and cilial export signal Newton, laplace, and the epistemology of systems biology.Identifying therapeutic targets by combining transcriptional data with ordinal clinical measurements.An Automated Home-Cage System to Assess Learning and Performance of a Skilled Motor Task in a Mouse Model of Huntington's Disease Huntingtin N17 domain is a reactive oxygen species sensor regulating huntingtin phosphorylation and localization.Motor phenotype is not associated with vascular dysfunction in symptomatic Huntington's disease transgenic R6/2 (160 CAG) mice The CLIMB (Complex Lipids In Mothers and Babies) study: protocol for a multicentre, three-group, parallel randomised controlled trial to investigate the effect of supplementation of complex lipids in pregnancy, on maternal ganglioside status and sub Huntingtin is a scaffolding protein in the ATM oxidative DNA damage response complex.Phosphorylation of huntingtin at residue T3 is decreased in Huntington's disease and modulates mutant huntingtin protein conformation.Glyco-sphingo biology: a novel perspective for potential new treatments in Huntington's disease.

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Ganglioside GM1 induces phosphorylation of mutant huntingtin and restores normal motor behavior in Huntington disease mice

http://www.wikidata.org/entity/Q30506469

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2012 nî lūn-bûn

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2012 թուականի Փետրուարին հրատարակուած գիտական յօդուած

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2012 թվականի փետրվարին հրատարակված գիտական հոդված

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2012年の論文

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2012年論文

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2012年論文

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2012年論文

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2012年論文

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2012年論文

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2012年论文

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Ganglioside GM1 induces phosph ...... ior in Huntington disease mice

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Ganglioside GM1 induces phosph ...... ior in Huntington disease mice

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Ganglioside GM1 induces phosph ...... ior in Huntington disease mice

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Ganglioside GM1 induces phosph ...... ior in Huntington disease mice

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PNAS.1114502109

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Proceedings of the National Academy of Sciences of the United States of America

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Ganglioside GM1 induces phosph ...... ior in Huntington disease mice

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P2093

Andrea Ciammola

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Jenny Sassone

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Joan S Steffan

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Melanie Alpaugh

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Melanie Horkey

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Randy S Atwal

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Ray Truant

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Simonetta Sipione

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P2860

Mechanisms for the modulation of dopamine d(1) receptor signaling in striatal neurons

Gangliosides for acute spinal cord injury

SUMO modification of Huntingtin and Huntington's disease pathology

Huntingtin has a membrane association signal that can modulate huntingtin aggregation, nuclear entry and toxicity

Lipid rafts and signal transduction

Exogenous gangliosides, neuronal plasticity and repair, and the neurotrophins

Long glutamine tracts cause nuclear localization of a novel form of huntingtin in medium spiny striatal neurons in HdhQ92 and HdhQ111 knock-in mice

IKK phosphorylates Huntingtin and targets it for degradation by the proteasome and lysosome.

Huntingtin phosphorylation sites mapped by mass spectrometry. Modulation of cleavage and toxicity.

Detection of alpha-rod protein repeats using a neural network and application to huntingtin.

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3528-3533

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10.1073/PNAS.1114502109

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9

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109

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Vittorio Maglione

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2012-02-13T00:00:00Z

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221830117

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22331905

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Huntington disease

phosphorylation

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3295265

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