A synthetic biology approach reveals a CXCR4-G13-Rho signaling axis driving transendothelial migration of metastatic breast cancer cells - Wikidata - wikimedia - TriplyDB

A synthetic biology approach reveals a CXCR4-G13-Rho signaling axis driving transendothelial migration of metastatic breast cancer cells

A synthetic biology approach reveals a CXCR4-G13-Rho signaling axis driving transendothelial migration of metastatic breast cancer cells

http://www.wikidata.org/entity/Q30524460

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G Protein-Coupled Receptors in Cancer The Use of DREADDs to Deconstruct Behavior Rho, ROCK and actomyosin contractility in metastasis as drug targets Chemokines and cytokines as salivary biomarkers for the early diagnosis of oral cancer Pharmacosynthetics: Reimagining the pharmacogenetic approach Novel insights into G protein and G protein-coupled receptor signaling in cancer The diacylglycerol kinase α/atypical PKC/β1 integrin pathway in SDF-1α mammary carcinoma invasiveness.A chemical biology approach demonstrates G protein βγ subunits are sufficient to mediate directional neutrophil chemotaxis.The emerging mutational landscape of G proteins and G-protein-coupled receptors in cancer.Breast cancer cell invasion mediated by Gα12 signaling involves expression of interleukins-6 and -8, and matrix metalloproteinase-2.Molecular pathogenesis of bone metastases in breast cancer: Proven and emerging therapeutic targets Heterotrimeric G-protein alpha-12 (Gα12) subunit promotes oral cancer metastasis.RhoA and ROCK mediate histamine-induced vascular leakage and anaphylactic shock.SDF-1/CXCL12 induces directional cell migration and spontaneous metastasis via a CXCR4/Gαi/mTORC1 axis.Cell growth density modulates cancer cell vascular invasion via Hippo pathway activity and CXCR2 signaling.A New DREADD Facilitates the Multiplexed Chemogenetic Interrogation of Behavior.Determinant role for the gep oncogenes, Gα12/13, in ovarian cancer cell proliferation and xenograft tumor growth.The G protein-coupled receptor P2RY8 and follicular dendritic cells promote germinal center confinement of B cells, whereas S1PR3 can contribute to their dissemination The Role of chemokine receptor CXCR4 in breast cancer metastasis Overexpression of proteasomal activator PA28α serves as a prognostic factor in oral squamous cell carcinoma MicroRNA-182 and microRNA-200a control G-protein subunit α-13 (GNA13) expression and cell invasion synergistically in prostate cancer cells.PDZ-RhoGEF and LARG are essential for embryonic development and provide a link between thrombin and LPA receptors and Rho activation Low-dose cisplatin-induced CXCR4 expression promotes proliferation of ovarian cancer stem-like cells.Inactivating mutations in GNA13 and RHOA in Burkitt's lymphoma and diffuse large B-cell lymphoma: a tumor suppressor function for the Gα13/RhoA axis in B cells.CXCR4 Regulates Extra-Medullary Myeloma through Epithelial-Mesenchymal-Transition-like Transcriptional Activation.Novel designer receptors to probe GPCR signaling and physiology PDZ-RhoGEF is essential for CXCR4-driven breast tumor cell motility through spatial regulation of RhoA.Resolving Behavioral Output via Chemogenetic Designer Receptors Exclusively Activated by Designer Drugs Krüppel-like factor 8 activates the transcription of C-X-C cytokine receptor type 4 to promote breast cancer cell invasion, transendothelial migration and metastasis.WNT Stimulation Dissociates a Frizzled 4 Inactive-State Complex with Gα12/13.Pepducin targeting the C-X-C chemokine receptor type 4 acts as a biased agonist favoring activation of the inhibitory G protein.Activation of the orphan receptor GPR55 by lysophosphatidylinositol promotes metastasis in triple-negative breast cancer.SDF-1/CXCR4 axis induces human dental pulp stem cell migration through FAK/PI3K/Akt and GSK3β/β-catenin pathways.Highly Expressed Integrin-α8 Induces Epithelial to Mesenchymal Transition-Like Features in Multiple Myeloma with Early Relapse.MicroRNA-126 inhibits colon cancer cell proliferation and invasion by targeting the chemokine (C-X-C motif) receptor 4 and Ras homolog gene family, member A, signaling pathway.CXCR4-based imaging agents.Are GPCRs still a source of new targets?Vascular permeability and drug delivery in cancers.The lymphatic system and pancreatic cancer.Toward total synthesis of cell function: Reconstituting cell dynamics with synthetic biology.

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P2860

A synthetic biology approach reveals a CXCR4-G13-Rho signaling axis driving transendothelial migration of metastatic breast cancer cells

http://www.wikidata.org/entity/Q30524460

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2011 nî lūn-bûn

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2011 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած

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2011 թվականի սեպտեմբերին հրատարակված գիտական հոդված

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2011年論文

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2011年論文

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A synthetic biology approach r ...... metastatic breast cancer cells

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A synthetic biology approach r ...... metastatic breast cancer cells

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A synthetic biology approach r ...... metastatic breast cancer cells

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A synthetic biology approach r ...... metastatic breast cancer cells

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A synthetic biology approach r ...... metastatic breast cancer cells

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Alfredo A Molinolo

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Hiroshi Yagi

http://www.w3.org/2001/XMLSchema#string

J Silvio Gutkind

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May Simaan

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Panomwat Amornphimoltham

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Patricia Dillenburg-Pilla

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Roberto Weigert

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Sylvain Armando

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Wenfu Tan

http://www.w3.org/2001/XMLSchema#string

P2860

Involvement of chemokine receptors in breast cancer metastasis

Interaction of Galpha 12 and Galpha 13 with the cytoplasmic domain of cadherin provides a mechanism for beta -catenin release

A collection of breast cancer cell lines for the study of functionally distinct cancer subtypes

A pleiotropically acting microRNA, miR-31, inhibits breast cancer metastasis

Evolving the lock to fit the key to create a family of G protein-coupled receptors potently activated by an inert ligand

Epithelial-mesenchymal transitions in development and disease

VEGF controls endothelial-cell permeability by promoting the beta-arrestin-dependent endocytosis of VE-cadherin

RGS-containing RhoGEFs: the missing link between transforming G proteins and Rho?

Transitions between epithelial and mesenchymal states: acquisition of malignant and stem cell traits

Cancer and the chemokine network

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10.1126/SCISIGNAL.2002221

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synthetic biology

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3429372

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