Rapamycin prevents seizures after depletion of STRADA in a rare neurodevelopmental disorder - Wikidata - wikimedia - TriplyDB

Rapamycin prevents seizures after depletion of STRADA in a rare neurodevelopmental disorder

Rapamycin prevents seizures after depletion of STRADA in a rare neurodevelopmental disorder

http://www.wikidata.org/entity/Q30541746

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STRAD pseudokinases regulate axogenesis and LKB1 stability Pathogenesis and new candidate treatments for infantile spasms and early life epileptic encephalopathies: A view from preclinical studies A clinical review on megalencephaly: A large brain as a possible sign of cerebral impairment.mTOR signaling in epilepsy: insights from malformations of cortical development Impaired Reelin-Dab1 Signaling Contributes to Neuronal Migration Deficits of Tuberous Sclerosis Complex Clemizole and modulators of serotonin signalling suppress seizures in Dravet syndrome.From Molecular Circuit Dysfunction to Disease: Case Studies in Epilepsy, Traumatic Brain Injury, and Alzheimer's Disease.A roadmap for precision medicine in the epilepsies.Early rescue of interneuron disease trajectory in developmental epilepsies.Epileptic spasms are a feature of DEPDC5 mTORopathy.Normalizing translation through 4E-BP prevents mTOR-driven cortical mislamination and ameliorates aberrant neuron integration.A critical review of mTOR inhibitors and epilepsy: from basic science to clinical trials.Mechanisms of epileptogenesis in pediatric epileptic syndromes: Rasmussen encephalitis, infantile spasms, and febrile infection-related epilepsy syndrome (FIRES).Pathogenetic mechanisms of focal cortical dysplasia.mTOR inhibition in epilepsy: rationale and clinical perspectives.Genetic animal models of malformations of cortical development and epilepsy.mTOR in Brain Physiology and Pathologies.Inflammation in Epileptic Encephalopathies.Tuberous sclerosis complex as a model disease for developing new therapeutics for epilepsy.Proteomic Analysis After Status Epilepticus Identifies UCHL1 as Protective Against Hippocampal Injury.The Impact of Next-Generation Sequencing on the Diagnosis and Treatment of Epilepsy in Paediatric Patients.DEPDC5 as a potential therapeutic target for epilepsy.Commentary: mTOR inhibition suppresses established epilepsy in a mouse model of cortical dysplasia.Rational therapy from bench to bedside for a rare epilepsy Sending Mixed Signals: The Expanding Role of Molecular Cascade Mutations in Malformations of Cortical Development and Epilepsy.Long-term treatment of epilepsy with everolimus in tuberous sclerosis.Everolimus treatment of refractory epilepsy in tuberous sclerosis complex.mTOR-Dependent Cell Proliferation in the Brain.Re-positioning of somatic Golgi apparatus is essential for the dendritic establishment of adult-born hippocampal neurons.Targeting the Mammalian Target of Rapamycin for Epileptic Encephalopathies and Malformations of Cortical Development.Familial focal epilepsy with focal cortical dysplasia due to DEPDC5 mutations.Mutations in the mammalian target of rapamycin pathway regulators NPRL2 and NPRL3 cause focal epilepsy.Mutations in mammalian target of rapamycin regulator DEPDC5 cause focal epilepsy with brain malformations.Increasing Cancer Screening Among Old Order Anabaptist Women Through Specialized Women's Health and Integrated Cancer Screening Interventions.Whole exome sequencing identifies the first STRADA point mutation in a patient with polyhydramnios, megalencephaly, and symptomatic epilepsy syndrome (PMSE).Seizures in Tuberous Sclerosis: Mechanism-Based Interventions EXIST.Sleep Related Epilepsy and Pharmacotherapy: An Insight

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P2860

Rapamycin prevents seizures after depletion of STRADA in a rare neurodevelopmental disorder

http://www.wikidata.org/entity/Q30541746

description

2013 nî lūn-bûn

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2013 թուականի Ապրիլին հրատարակուած գիտական յօդուած

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2013 թվականի ապրիլին հրատարակված գիտական հոդված

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2013年の論文

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2013年論文

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2013年論文

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2013年論文

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2013年論文

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2013年論文

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2013年论文

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name

Rapamycin prevents seizures af ...... re neurodevelopmental disorder

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Rapamycin prevents seizures af ...... re neurodevelopmental disorder

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type

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Rapamycin prevents seizures af ...... re neurodevelopmental disorder

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Rapamycin prevents seizures af ...... re neurodevelopmental disorder

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Rapamycin prevents seizures af ...... re neurodevelopmental disorder

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Rapamycin prevents seizures af ...... re neurodevelopmental disorder

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SCITRANSLMED.3005271

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Science Translational Medicine

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Rapamycin prevents seizures af ...... re neurodevelopmental disorder

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Dmitry A Goncharov

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Jacqueline F Birnbaum

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Jelte Helfferich

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Kei Okochi

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Kevin A Strauss

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Ksenia A Orlova

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Marianna Baybis

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Peter B Crino

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Vera P Krymskaya

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Whitney E Parker

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P2860

Complexes between the LKB1 tumor suppressor, STRAD alpha/beta and MO25 alpha/beta are upstream kinases in the AMP-activated protein kinase cascade

LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1

Structure of the LKB1-STRAD-MO25 complex reveals an allosteric mechanism of kinase activation

Finding a better drug for epilepsy: the mTOR pathway as an antiepileptogenic target

The LKB1 tumor suppressor negatively regulates mTOR signaling

Rapamycin causes regression of astrocytomas in tuberous sclerosis complex

TSC2 modulates actin cytoskeleton and focal adhesion through TSC1-binding domain and the Rac1 GTPase

Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity

Regulation of actin dynamics through phosphorylation of cofilin by LIM-kinase

Recessive symptomatic focal epilepsy and mutant contactin-associated protein-like 2

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scholarly article

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10.1126/SCITRANSLMED.3005271

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182

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5

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2013-04-01T00:00:00Z

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236328547

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23616120

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neurodevelopmental disorders

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3720125

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