Rapamycin extends murine lifespan but has limited effects on aging. - Wikidata - wikimedia - TriplyDB

Rapamycin extends murine lifespan but has limited effects on aging.

Rapamycin extends murine lifespan but has limited effects on aging.

http://www.wikidata.org/entity/Q30541884

about

Finding Ponce de Leon's Pill: Challenges in Screening for Anti-Aging Molecules INFRAFRONTIER: a European resource for studying the functional basis of human disease Geroscience approaches to increase healthspan and slow aging Inhibition of the Mechanistic Target of Rapamycin (mTOR)-Rapamycin and Beyond The role of the ribosome in the regulation of longevity and lifespan extension Biochemical Genetic Pathways that Modulate Aging in Multiple Species MYC, Metabolism, and Cancer Identification of Atypical Peri-Nuclear Multivesicular Bodies in Oxidative and Glycolytic Skeletal Muscle of Aged and Pompe's Disease Mouse Models.Reduced expression of MYC increases longevity and enhances healthspan.Abnormal brain iron metabolism in Irp2 deficient mice is associated with mild neurological and behavioral impairments Potential therapeutic effects of the MTOR inhibitors for preventing ageing and progeria-related disorders Longevity and skeletal muscle mass: the role of IGF signalling, the sirtuins, dietary restriction and protein intake Essential role for autophagy in life span extension mTOR signaling in tumorigenesis Intermittent Administration of Rapamycin Extends the Life Span of Female C57BL/6J Mice Rapamycin-mediated lifespan increase in mice is dose and sex dependent and metabolically distinct from dietary restriction Lifespan extension and cancer prevention in HER-2/neu transgenic mice treated with low intermittent doses of rapamycin Temsirolimus Partially Rescues the Hutchinson-Gilford Progeria Cellular Phenotype 17ß-Estradiol regulates mTORC2 sensitivity to rapamycin in adaptive cardiac remodeling Effect of Chronic Administration of Low Dose Rapamycin on Development and Immunity in Young Rats 10-Hydroxy-2-decenoic Acid, the Major Lipid Component of Royal Jelly, Extends the Lifespan of Caenorhabditis elegans through Dietary Restriction and Target of Rapamycin Signaling Pleiotropic functions for transcription factor zscan10.High-dose maternal folic acid supplementation before conception impairs reversal learning in offspring mice.Canonical Nlrp3 inflammasome links systemic low-grade inflammation to functional decline in aging.Preserving youth: does rapamycin deliver?Recent progress in metabolic signaling pathways regulating aging and life span Altered proteome turnover and remodeling by short-term caloric restriction or rapamycin rejuvenate the aging heart.Longevity pathways and memory aging eRapa restores a normal life span in a FAP mouse model.Sirtuins: guardians of mammalian healthspan.In search of antiaging modalities: evaluation of mTOR- and ROS/DNA damage-signaling by cytometry.Immune memory-boosting dose of rapamycin impairs macrophage vesicle acidification and curtails glycolysis in effector CD8 cells, impairing defense against acute infections Biotechnological applications derived from microorganisms of the Atacama Desert Acute mTOR inhibition induces insulin resistance and alters substrate utilization in vivo Tissue depletion of taurine accelerates skeletal muscle senescence and leads to early death in mice.Berberine suppresses gero-conversion from cell cycle arrest to senescence.Combined treatment of rapamycin and dietary restriction has a larger effect on the transcriptome and metabolome of liver.Longevity, aging and rapamycin.Rapamycin and dietary restriction induce metabolically distinctive changes in mouse liver.Testing efficacy of administration of the antiaging drug rapamycin in a nonhuman primate, the common marmoset.

P2860

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P2860

Rapamycin extends murine lifespan but has limited effects on aging.

http://www.wikidata.org/entity/Q30541884

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2013 nî lūn-bûn

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2013 թուականի Յուլիսին հրատարակուած գիտական յօդուած

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2013 թվականի հուլիսին հրատարակված գիտական հոդված

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2013年の論文

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2013年論文

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2013年論文

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2013年論文

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2013年論文

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2013年論文

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2013年论文

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name

Rapamycin extends murine lifespan but has limited effects on aging.

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Rapamycin extends murine lifespan but has limited effects on aging.

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type

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Rapamycin extends murine lifespan but has limited effects on aging.

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Rapamycin extends murine lifespan but has limited effects on aging.

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Rapamycin extends murine lifespan but has limited effects on aging.

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Rapamycin extends murine lifespan but has limited effects on aging.

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P1433

Journal of Clinical Investigation

P1476

Rapamycin extends murine lifespan but has limited effects on aging.

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P2093

Andreas Zimmer

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Beatrix Naton

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Birgit Rathkolb

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Dan Ehninger

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Diana Flores-Dominguez

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Dirk H Busch

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Frauke Neff

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Heinz Höfler

http://www.w3.org/2001/XMLSchema#string

Helmut Fuchs

http://www.w3.org/2001/XMLSchema#string

Ildikó Rácz

http://www.w3.org/2001/XMLSchema#string

P2860

Extension of chronological life span in yeast by decreased TOR pathway signaling

Rapamycin, but not resveratrol or simvastatin, extends life span of genetically heterogeneous mice

Regulation of lifespan in Drosophila by modulation of genes in the TOR signaling pathway

Rapamycin fed late in life extends lifespan in genetically heterogeneous mice

The TOR pathway interacts with the insulin signaling pathway to regulate C. elegans larval development, metabolism and life span

Regulation of yeast replicative life span by TOR and Sch9 in response to nutrients

CellProfiler: free, versatile software for automated biological image analysis

Ribosomal protein S6 kinase 1 signaling regulates mammalian life span

Genetics: influence of TOR kinase on lifespan in C. elegans

Mouse phenotyping.

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3272-3291

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10.1172/JCI67674

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8

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123

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Gerhard Ehninger

Martin Klingenspor

Martin Hrabě de Angelis

Valérie Gailus-Durner

Sabine M. Hölter

Lillian Garrett

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2013-07-25T00:00:00Z

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249997006

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23863708

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3726163

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