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The one-two punch of alcoholism: role of central amygdala dynorphins/kappa-opioid receptors

The one-two punch of alcoholism: role of central amygdala dynorphins/kappa-opioid receptors

http://www.wikidata.org/entity/Q30543310

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Nalmefene: a new approach to the treatment of alcohol dependence Asymmetry of the endogenous opioid system in the human anterior cingulate: a putative molecular basis for lateralization of emotions and pain.Effects of rearing conditions on behaviour and endogenous opioids in rats with alcohol access during adolescence Effects of chronic ethanol exposure on neuronal function in the prefrontal cortex and extended amygdala.Anticipatory 50 kHz ultrasonic vocalizations are associated with escalated alcohol intake in dependent rats.Operant alcohol self-administration in dependent rats: focus on the vapor model The kappa opioid receptor: from addiction to depression, and back.Alcohol-induced changes in opioid peptide levels in adolescent rats are dependent on housing conditions Voluntary ethanol intake predicts κ-opioid receptor supersensitivity and regionally distinct dopaminergic adaptations in macaques Kappa opioid receptor signaling in the brain: Circuitry and implications for treatment.The opioid receptors as targets for drug abuse medication Maturational alterations in constitutive activity of medial prefrontal cortex kappa-opioid receptors in Wistar rats Stress-Induced Enhancement of Ethanol Intake in C57BL/6J Mice with a History of Chronic Ethanol Exposure: Involvement of Kappa Opioid Receptors.Forced swim stress increases ethanol consumption in C57BL/6J mice with a history of chronic intermittent ethanol exposure Species differences in the effects of the κ-opioid receptor antagonist zyklophin.Supersensitive Kappa Opioid Receptors Promotes Ethanol Withdrawal-Related Behaviors and Reduce Dopamine Signaling in the Nucleus Accumbens.Dissociable effects of kappa-opioid receptor activation on impulsive phenotypes in wistar rats.Distinct Effects of Nalmefene on Dopamine Uptake Rates and Kappa Opioid Receptor Activity in the Nucleus Accumbens Following Chronic Intermittent Ethanol Exposure.Upregulated dynorphin opioid peptides mediate alcohol-induced learning and memory impairment.Kappa-opioid receptors differentially regulate low and high levels of ethanol intake in female mice.Dissociating Motivational From Physiological Withdrawal in Alcohol Dependence: Role of Central Amygdala κ-Opioid Receptors.Investigational therapies for the pharmacological treatment of alcoholism.Postdependent state in rats as a model for medication development in alcoholism.Role of κ-Opioid Receptors in the Bed Nucleus of Stria Terminalis in Reinstatement of Alcohol Seeking.The Role of NFkB in Drug Addiction: Beyond Inflammation.Basolateral to Central Amygdala Neural Circuits for Appetitive Behaviors.Role of the Dynorphin/Kappa Opioid Receptor System in the Motivational Effects of Ethanol.Influence of stress associated with chronic alcohol exposure on drinking.Early-Life Social Isolation Stress Increases Kappa Opioid Receptor Responsiveness and Downregulates the Dopamine System Switch from excitatory to inhibitory actions of ethanol on dopamine levels after chronic exposure: Role of kappa opioid receptors.Age-dependent regulation of GABA transmission by kappa opioid receptors in the basolateral amygdala of Sprague-Dawley rats.Synergistic blockade of alcohol escalation drinking in mice by a combination of novel kappa opioid receptor agonist Mesyl Salvinorin B and naltrexone.CRF1 Receptor-Dependent Increases in Irritability-Like Behavior During Abstinence from Chronic Intermittent Ethanol Vapor Exposure.Intermittent Access to Ethanol Drinking Facilitates the Transition to Excessive Drinking After Chronic Intermittent Ethanol Vapor Exposure.Dynorphin and κ-Opioid Receptor Dysregulation in the Dopaminergic Reward System of Human Alcoholics.Preclinical evaluation of the kappa-opioid receptor antagonist CERC-501 as a candidate therapeutic for alcohol use disorders.Involvement of activated brain stress responsive systems in excessive and "relapse" alcohol drinking in rodent models: implications for therapeutics.Downregulation of the neuronal opioid gene expression concomitantly with neuronal decline in dorsolateral prefrontal cortex of human alcoholics.

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The one-two punch of alcoholism: role of central amygdala dynorphins/kappa-opioid receptors

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2013 nî lūn-bûn

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2013 թուականի Ապրիլին հրատարակուած գիտական յօդուած

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2013 թվականի ապրիլին հրատարակված գիտական հոդված

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2013年の論文

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2013年論文

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2013年論文

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2013年論文

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The one-two punch of alcoholis ...... orphins/kappa-opioid receptors

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The one-two punch of alcoholis ...... orphins/kappa-opioid receptors

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Brendan M Walker

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Daniel G Smith

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Daniel J Reis

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Heiko T Jansen

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P2860

The relative potency of inverse opioid agonists and a neutral opioid antagonist in precipitated withdrawal and antagonism of analgesia and toxicity

Dynorphin, stress, and depression

Pharmacological evidence for a motivational role of kappa-opioid systems in ethanol dependence

Association of the kappa-opioid system with alcohol dependence

Constitutive activity of the delta-opioid receptor expressed in C6 glioma cells: identification of non-peptide delta-inverse agonists

An opponent-process theory of motivation: I. Temporal dynamics of affect.

New perspectives in basal forebrain organization of special relevance for neuropsychiatric disorders: the striatopallidal, amygdaloid, and corticopetal components of substantia innominata.

30 years of dynorphins--new insights on their functions in neuropsychiatric diseases

Activation of the kappa opioid receptor in the dorsal raphe nucleus mediates the aversive effects of stress and reinstates drug seeking.

Enkephalins, dynorphins, and beta-endorphin in the rat dorsal horn: an immunofluorescence colocalization study

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