The dynein regulatory complex is required for ciliary motility and otolith biogenesis in the inner ear.
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CEP41 is mutated in Joubert syndrome and is required for tubulin glutamylation at the ciliumMutations in axonemal dynein assembly factor DNAAF3 cause primary ciliary dyskinesia.Combining Cep290 and Mkks ciliopathy alleles in mice rescues sensory defects and restores ciliogenesisCCDC39 is required for assembly of inner dynein arms and the dynein regulatory complex and for normal ciliary motility in humans and dogsThe nexin-dynein regulatory complex subunit DRC1 is essential for motile cilia function in algae and humans.GRK2: multiple roles beyond G protein-coupled receptor desensitizationUnexpected link between polyketide synthase and calcium carbonate biomineralization.High magnetic field induced otolith fusion in the zebrafish larvae.Loss-of-Function GAS8 Mutations Cause Primary Ciliary Dyskinesia and Disrupt the Nexin-Dynein Regulatory ComplexNovel roles for the radial spoke head protein 9 in neural and neurosensory cilia.Vestibular dysfunction, altered macular structure and trait localization in A/J inbred mice.Bisphenol A induces otolith malformations during vertebrate embryogenesis.CMF70 is a subunit of the dynein regulatory complex.Oda16/Wdr69 is essential for axonemal dynein assembly and ciliary motility during zebrafish embryogenesisThe N-DRC forms a conserved biochemical complex that maintains outer doublet alignment and limits microtubule sliding in motile axonemes.CMF22 is a broadly conserved axonemal protein and is required for propulsive motility in Trypanosoma brucei.NPHP4 variants are associated with pleiotropic heart malformations.Gli2a protein localization reveals a role for Iguana/DZIP1 in primary ciliogenesis and a dependence of Hedgehog signal transduction on primary cilia in the zebrafish.The dynein regulatory complex is the nexin link and a major regulatory node in cilia and flagella.Mechanistic basis of otolith formation during teleost inner ear developmentThe global phosphoproteome of Chlamydomonas reinhardtii reveals complex organellar phosphorylation in the flagella and thylakoid membrane.Microfluidic characterization of cilia-driven fluid flow using optical coherence tomography-based particle tracking velocimetry.Growth Arrest Specific 8 (Gas8) and G protein-coupled receptor kinase 2 (GRK2) cooperate in the control of Smoothened signalingBuilding blocks of the nexin-dynein regulatory complex in Chlamydomonas flagella.Mechanisms of otoconia and otolith developmentFluid flows and forces in development: functions, features and biophysical principles.Mutation analysis in patients with total sperm immotilityThe Trypanosoma brucei flagellum: moving parasites in new directions.Update in pediatric lung disease 2008.The pathophysiology of bronchiectasisSmall tubules, surprising discoveries: from efferent ductules in the turkey to the discovery that estrogen receptor alpha is essential for fertility in the malePrimary ciliary dyskinesia: recent advances in epidemiology, diagnosis, management and relationship with the expanding spectrum of ciliopathy.Formation of the inner ear during embryonic and larval development of the cichlid fish (Oreochromis mossambicus).Mutations in GAS8, a Gene Encoding a Nexin-Dynein Regulatory Complex Subunit, Cause Primary Ciliary Dyskinesia with Axonemal Disorganization.Wnt/β-catenin signaling directly regulates Foxj1 expression and ciliogenesis in zebrafish Kupffer's vesicle.The role of hair cells, cilia and ciliary motility in otolith formation in the zebrafish otic vesicle.Zebrafish ift57, ift88, and ift172 intraflagellar transport mutants disrupt cilia but do not affect hedgehog signaling.DRC2/CCDC65 is a central hub for assembly of the nexin-dynein regulatory complex and other regulators of ciliary and flagellar motility.Functional characterization of tektin-1 in motile cilia and evidence for TEKT1 as a new candidate gene for motile ciliopathies.Claudin7b is required for the formation and function of inner ear in zebrafish.
P2860
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P2860
The dynein regulatory complex is required for ciliary motility and otolith biogenesis in the inner ear.
description
2008 nî lūn-bûn
@nan
2008 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年学术文章
@wuu
2008年学术文章
@zh-cn
2008年学术文章
@zh-hans
2008年学术文章
@zh-my
2008年学术文章
@zh-sg
2008年學術文章
@yue
name
The dynein regulatory complex ...... h biogenesis in the inner ear.
@ast
The dynein regulatory complex ...... h biogenesis in the inner ear.
@en
type
label
The dynein regulatory complex ...... h biogenesis in the inner ear.
@ast
The dynein regulatory complex ...... h biogenesis in the inner ear.
@en
prefLabel
The dynein regulatory complex ...... h biogenesis in the inner ear.
@ast
The dynein regulatory complex ...... h biogenesis in the inner ear.
@en
P2093
P2860
P356
P1433
P1476
The dynein regulatory complex ...... h biogenesis in the inner ear.
@en
P2093
Adam D Langenbacher
Jessica R Colantonio
Julien Vermot
Kent L Hill
P2860
P2888
P304
P356
10.1038/NATURE07520
P407
P577
2008-11-30T00:00:00Z
P6179
1023428468