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A small-molecule approach to studying invasive mechanisms of Toxoplasma gondii

A small-molecule approach to studying invasive mechanisms of Toxoplasma gondii

http://www.wikidata.org/entity/Q30583763

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A small-molecule screen identifies the antipsychotic drug pimozide as an inhibitor of Listeria monocytogenes infection Quinoxaline 1,4-di-N-Oxides: Biological Activities and Mechanisms of Actions High content screening in chemical biology: overview and main challenges Chemical biology approaches for the study of apicomplexan parasites The Conoid Associated Motor MyoH Is Indispensable for Toxoplasma gondii Entry and Exit from Host Cells Toxoplasma MIC2 is a major determinant of invasion and virulence Identification of TgCBAP, a novel cytoskeletal protein that localizes to three distinct subcompartments of the Toxoplasma gondii pellicle Disruption of TgPHIL1 alters specific parameters of Toxoplasma gondii motility measured in a quantitative, three-dimensional live motility assay The motility of a human parasite, Toxoplasma gondii, is regulated by a novel lysine methyltransferase A small-molecule inhibitor of T. gondii motility induces the posttranslational modification of myosin light chain-1 and inhibits myosin motor activity The P-glycoprotein inhibitor GF120918 modulates Ca2+-dependent processes and lipid metabolism in Toxoplasma gondii Identification of T. gondii myosin light chain-1 as a direct target of TachypleginA-2, a small-molecule inhibitor of parasite motility and invasion A DOC2 protein identified by mutational profiling is essential for apicomplexan parasite exocytosis A genome-wide over-expression screen identifies genes involved in phagocytosis in the human protozoan parasite, Entamoeba histolytica.A focused small-molecule screen identifies 14 compounds with distinct effects on Toxoplasma gondii.Calcium-dependent phosphorylation alters class XIVa myosin function in the protozoan parasite Toxoplasma gondii The toxoplasma-host cell junction is anchored to the cell cortex to sustain parasite invasive force Laser scanning cytometer-based assays for measuring host cell attachment and invasion by the human pathogen Toxoplasma gondii Identification and characterization of small molecules that inhibit intracellular toxin transport Using small molecules to dissect mechanisms of microbial pathogenesis.Communication between Toxoplasma gondii and its host: impact on parasite growth, development, immune evasion, and virulence.Whole genome profiling of spontaneous and chemically induced mutations in Toxoplasma gondii Small-molecule inhibitors specifically targeting type III secretion.The MAP kinase-activated protein kinase 2 (MK2) contributes to the Shiga toxin-induced inflammatory response Conditional expression of Toxoplasma gondii apical membrane antigen-1 (TgAMA1) demonstrates that TgAMA1 plays a critical role in host cell invasion Comprehensive proteomic analysis of membrane proteins in Toxoplasma gondii.Increasing the Content of High-Content Screening: An Overview An overexpression screen of Toxoplasma gondii Rab-GTPases reveals distinct transport routes to the micronemes A systems biological view of intracellular pathogens A novel high throughput invasion screen identifies host actin regulators required for efficient cell entry by Toxoplasma gondii.Small-molecule inhibition of a depalmitoylase enhances Toxoplasma host-cell invasion.Chemical genetic screen identifies Toxoplasma DJ-1 as a regulator of parasite secretion, attachment, and invasion.The apical complex provides a regulated gateway for secretion of invasion factors in Toxoplasma.Cysteine protease inhibitors block Toxoplasma gondii microneme secretion and cell invasion Molecular cloning and characterization of mitogen-activated protein kinase 2 in Toxoplasma gondii.Discovery of a novel Toxoplasma gondii conoid-associated protein important for parasite resistance to reactive nitrogen intermediates.Research advances in microneme protein 3 of Toxoplasma gondii.Studying the cell biology of apicomplexan parasites using fluorescent proteins.A genetic screen to isolate Toxoplasma gondii host-cell egress mutants Screening and synthesis: high throughput technologies applied to parasitology.

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P2860

A small-molecule approach to studying invasive mechanisms of Toxoplasma gondii

http://www.wikidata.org/entity/Q30583763

description

2004 nî lūn-bûn

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2004 թուականի Մայիսին հրատարակուած գիտական յօդուած

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2004 թվականի մայիսին հրատարակված գիտական հոդված

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2004年の論文

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2004年論文

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2004年論文

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2004年論文

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2004年論文

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2004年論文

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2004年论文

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name

A small-molecule approach to studying invasive mechanisms of Toxoplasma gondii

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A small-molecule approach to studying invasive mechanisms of Toxoplasma gondii

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A small-molecule approach to studying invasive mechanisms of Toxoplasma gondii

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A small-molecule approach to studying invasive mechanisms of Toxoplasma gondii

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prefLabel

A small-molecule approach to studying invasive mechanisms of Toxoplasma gondii

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A small-molecule approach to studying invasive mechanisms of Toxoplasma gondii

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Proceedings of the National Academy of Sciences of the United States of America

P1476

A small-molecule approach to studying invasive mechanisms of Toxoplasma gondii

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P2093

Gary E Ward

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Kimberly L Carey

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Nicholas J Westwood

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Timothy J Mitchison

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P2860

Role of Toxoplasma gondii myosin A in powering parasite gliding and host cell invasion

The specificities of protein kinase inhibitors: an update

Actin filament polymerization regulates gliding motility by apicomplexan parasites.

Time-lapse video microscopy of gliding motility in Toxoplasma gondii reveals a novel, biphasic mechanism of cell locomotion.

Genetic complementation in apicomplexan parasites

Molecular characterization of TgMIC5, a proteolytically processed antigen secreted from the micronemes of Toxoplasma gondii.

Toxoplasma gondii myosin A and its light chain: a fast, single-headed, plus-end-directed motor

Targeting bacterial virulence: inhibitors of type III secretion in Yersinia.

A Toxoplasma gondii rhoptry protein associated with host cell penetration has unusual charge asymmetry.

Ionophore-resistant mutants of Toxoplasma gondii reveal host cell permeabilization as an early event in egress.

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P921

Toxoplasma gondii

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409936

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