Autophagy inhibition for chemosensitization and radiosensitization in cancer: do the preclinical data support this therapeutic strategy? - Wikidata - wikimedia - TriplyDB

Autophagy inhibition for chemosensitization and radiosensitization in cancer: do the preclinical data support this therapeutic strategy?

Autophagy inhibition for chemosensitization and radiosensitization in cancer: do the preclinical data support this therapeutic strategy?

http://www.wikidata.org/entity/Q30584653

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Autophagy in cancer Chloroquine-enhanced efficacy of cisplatin in the treatment of hypopharyngeal carcinoma in xenograft mice Induction of autophagy is an early response to gefitinib and a potential therapeutic target in breast cancer Chloroquine is a zinc ionophore STAT3-mediated autophagy dependence identifies subtypes of breast cancer where autophagy inhibition can be efficacious.Sunitinib-induced morpho-functional changes and drug effectiveness in malignant solitary fibrous tumours Autophagy and cancer therapy.Targeting autophagy in breast cancer.Crosstalk between apoptosis and autophagy: molecular mechanisms and therapeutic strategies in cancer.Phase I clinical trial and pharmacodynamic evaluation of combination hydroxychloroquine and doxorubicin treatment in pet dogs treated for spontaneously occurring lymphoma The antimalarial amodiaquine causes autophagic-lysosomal and proliferative blockade sensitizing human melanoma cells to starvation- and chemotherapy-induced cell death.Bafilomycin A1 targets both autophagy and apoptosis pathways in pediatric B-cell acute lymphoblastic leukemia Yet another function of p53--the switch that determines whether radiation-induced autophagy will be cytoprotective or nonprotective: implications for autophagy inhibition as a therapeutic strategy Lithium Modulates Autophagy in Esophageal and Colorectal Cancer Cells and Enhances the Efficacy of Therapeutic Agents In Vitro and In Vivo.Downregulation of ATG14 by EGR1-MIR152 sensitizes ovarian cancer cells to cisplatin-induced apoptosis by inhibiting cyto-protective autophagy Inhibition of autophagy as a new means of improving chemotherapy efficiency in high-LC3B triple-negative breast cancers Role of autophagy-related protein expression in patients with rectal cancer treated with neoadjuvant chemoradiotherapy Autophagy Inhibition Delays Early but Not Late-Stage Metastatic Disease.TAT-ODD-p53 enhances the radiosensitivity of hypoxic breast cancer cells by inhibiting Parkin-mediated mitophagy.Autophagy Inhibition to Increase Radiosensitization in Breast Cancer.Autophagic degradation of aquaporin-2 is an early event in hypokalemia-induced nephrogenic diabetes insipidus Chloroquine enhances the efficacy of cisplatin by suppressing autophagy in human adrenocortical carcinoma treatment.Radiosensitization by PARP Inhibition in DNA Repair Proficient and Deficient Tumor Cells: Proliferative Recovery in Senescent Cells Combined antiproliferative effects of the aminoalkylindole WIN55,212-2 and radiation in breast cancer cells.The autophagy inhibitor verteporfin moderately enhances the antitumor activity of gemcitabine in a pancreatic ductal adenocarcinoma model.p62/sequestosome-1 up-regulation promotes ABT-263-induced caspase-8 aggregation/activation on the autophagosome Acidic extracellular pH neutralizes the autophagy-inhibiting activity of chloroquine: implications for cancer therapies.Autophagy in prostate cancer and androgen suppression therapy.Interferon-regulatory factor-1 (IRF1) regulates bevacizumab induced autophagy.Study protocol of a phase IB/II clinical trial of metformin and chloroquine in patients with IDH1-mutated or IDH2-mutated solid tumours Lysosomotropism depends on glucose: a chloroquine resistance mechanism Clinical relevance of autophagic therapy in cancer: Investigating the current trends, challenges, and future prospects.Autophagy is not uniformly cytoprotective: a personalized medicine approach for autophagy inhibition as a therapeutic strategy in non-small cell lung cancer.Three-dimensional microenvironment confers enhanced sensitivity to doxorubicin by reducing p53-dependent induction of autophagy.Research progress of hydroxychloroquine and autophagy inhibitors on cancer.Manipulation of autophagy in cancer cells: an innovative strategy to fight drug resistance.Enhanced autophagy in colorectal cancer stem cells does not contribute to radio-resistance Role of autophagy in regulating the radiosensitivity of tumor cells.The Challenge of Developing Autophagy Inhibition as a Therapeutic Strategy.Low concentration of chloroquine enhanced efficacy of cisplatin in the treatment of human ovarian cancer dependent on autophagy

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P2860

Autophagy inhibition for chemosensitization and radiosensitization in cancer: do the preclinical data support this therapeutic strategy?

http://www.wikidata.org/entity/Q30584653

description

2013 nî lūn-bûn

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2013 թուականի Յունուարին հրատարակուած գիտական յօդուած

@hyw

2013 թվականի հունվարին հրատարակված գիտական հոդված

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2013年の論文

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2013年学术文章

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2013年学术文章

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2013年学术文章

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2013年学术文章

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2013年学术文章

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2013年學術文章

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name

Autophagy inhibition for chemo ...... ort this therapeutic strategy?

@ast

Autophagy inhibition for chemo ...... ort this therapeutic strategy?

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type

label

Autophagy inhibition for chemo ...... ort this therapeutic strategy?

@ast

Autophagy inhibition for chemo ...... ort this therapeutic strategy?

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prefLabel

Autophagy inhibition for chemo ...... ort this therapeutic strategy?

@ast

Autophagy inhibition for chemo ...... ort this therapeutic strategy?

@en

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JPET.112.199802

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Journal of Pharmacology and Experimental Therapeutics

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Autophagy inhibition for chemo ...... ort this therapeutic strategy?

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Andrew Thorburn

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David A Gewirtz

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Molly L Bristol

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Sean M Emery

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Shweta Chakradeo

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Guidelines for the use and interpretation of assays for monitoring autophagy

Inhibition of macroautophagy triggers apoptosis

Perifosine inhibits mammalian target of rapamycin signaling through facilitating degradation of major components in the mTOR axis and induces autophagy

DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation

Randomized dose-ranging controlled trial of AQ-13, a candidate antimalarial, and chloroquine in healthy volunteers

Methods in mammalian autophagy research

Autophagy-dependent anticancer immune responses induced by chemotherapeutic agents in mice

Autophagy inhibition enhances therapy-induced apoptosis in a Myc-induced model of lymphoma

Chloroquine sensitizes breast cancer cells to chemotherapy independent of autophagy

Targeting the PI3K/mTOR axis, alone and in combination with autophagy blockade, for the treatment of malignant peripheral nerve sheath tumors

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